Short-Term Efficacy of Intraarticular Hyaluronic Acid Injection in Gonarthrosis

Abstract

Introduction:

Gonarthrosis is a chronic, degenerative disease that causes pain and stiffness. There are many treatment methods defined as conservative and surgical. Intra-articular hyaluronic acid injection is one of these methods. There are different preparations routinely used in the treatment. There is no clear evidence of which is more effective. We aimed to investigate the effectiveness of HA preparations with different molecular weights on pain and functionality of patients with gonarthrosis.

 

Material and Methods

30 of 55 patients (ranging 40-80 years old) diagnosed  as bilateral gonarthrosis were enrolled in the study. Patients were randomly divided into 3 groups (Hyalgan (N = 10), Orthovics (N = 10), Synvisc (N = 10)). Patients were evaluated before and after treatment. Clinical examination, Visual Analogue Scale, WOMAC score, stiffness and physical condition, 15 m walking time and 15 steps up and down performance were evaluated.

 

Results

             There was no significant difference between the groups in terms of age, body mass index (BMI) and symptom duration (p: 0.917, p: 0.721, p: 0.519, respectively). In all three groups, pre-treatment VAS scores (motion, rest and night) significantly decreased after treatment (p <0.001). According to WOMAC results, pain, stiffness decreased significantly after treatment (p <0.001). There was no significant difference between the groups in any parameter (p> 0.05).

Conclusion

The results of this study revealed no statistically significant difference between HA preparations in WOMAC and VAS scores; However, HA has been found to be effective and should be used in the treatment of early stage gonarthrosis.

Keywords

• Hyaluronic acid,injection,Gonarthrosis,Molecular weight

Gonartrozda İntra-artiküler Hyalüronik Asid Enjeksiyonunun Kısa Dönem Etkinliği

Abstract

Giriş:

Gonartroz, ağrı ve sertliğe neden olan kronik, dejeneratif bir hastalıktır. Konservatif ve cerrahi olarak tanımlanan birçok tedavi yöntemi vardır. Eklem içi hyaluronik asit enjeksiyonu bu yöntemlerden biridir. Tedavide rutin olarak kullanılan farklı preparatlar vardır ve hangisinin daha etkili olduğuna dair net bir kanıt yok. Farklı molekül ağırlıklarına sahip HA preparatlarının gonartrozu olan hastaların ağrı ve işlevselliği üzerine etkilerini araştırmayı amaçladık.

Gereç ve Yöntem

İki taraflı gonartroz tanısı konan 55 hastanın 30'u (40-80 yaşları arasında) çalışmaya alındı. Hastalar rastgele 3 gruba ayrıldı (Hyalgan (N = 10), Ortez (N = 10), Synvisc (N = 10)). Hastalar tedaviden önce ve sonra değerlendirildi. Klinik muayene, Görsel Analog Skala, WOMAC skoru, sertlik ve fiziksel durum, 15 m yürüme süresi ve 15 basamak yukarı ve aşağı performans değerlendirildi.

Bulgular

Gruplar arasında yaş, vücut kitle indeksi (BKİ) ve semptom süresi açısından anlamlı fark yoktu (sırasıyla p: 0.917, p: 0.721, p: 0.519). Her üç grupta da tedavi öncesi VAS skorları (hareket, dinlenme ve gece) tedaviden sonra anlamlı olarak azaldı (p <0.001). WOMAC sonuçlarına göre tedaviden sonra ağrı, sertlik belirgin olarak azaldı (p <0.001). Herhangi bir parametrede gruplar arasında anlamlı fark bulunmadı (p> 0.05).

Sonuç

Bu çalışmanın sonuçları, WOMAC ve VAS skorlarındaki HA preparatları arasında istatistiksel olarak anlamlı bir fark olmadığını ortaya koydu; Bununla birlikte, HA'nın etkili olduğu ve erken evre gonartroz tedavisinde kullanılması gerektiği bulunmuştur.

Keywords

• Hyaluronik asit,enjeksiyon,Gonartroz,Moleküler ağırlık

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