Plateletten Zengin Plazma Uygulama Sıklığının Erken Evre Diz Osteoartriti Üzerine Etkisi

Abstract

ÖZET Giriş: Plateletten zengin plazma (PRP) erken evre diz osteoartritinde (OA), özellikle genç hastalarda ağrıyı azaltıp fonksiyonu arttırarak iyi sonuçlar sağlamaktadır. Ancak ideal dozun ne olduğu ve kaç kere yapılması gerektiği, farklı OA evrelerindeki etkinliği tartışılagelen konulardır. Literatürde uygulama sıklığı ile PRP etkinliğini karşılaştıran az sayıda çalışma vardır. Bu çalışmanın amacı, primer diz OA hastalarında PRP uygulama sıklığının etkinliğini kıyaslamaktır. Materyal ve Metod: Ocak 2016 ile Nisan 2017 arasında kriterlere uygun 174 hasta geriye dönük olarak incelendi. Hastalar uygulama doz sayılarına göre 3 gruba bölündü. Tedaviden önce ve tedaviden sonraki 6. ve 12. aylarda Western Ontario and McMaster University Arthritis Index (WOMAC) skorları, International Knee Documentation Committee (IKDC) skorları ve 100 mm Visual Analogue Scale (100 mm VAS) skorları ölçüldü. Hastaların memnuniyet durumu ve tedaviye bağlı komplikasyonlar 12. ayda değerlendirildi. Bulgular: Takip sonunda her 3 grupta tedavi öncesi değerlere göre iyileşme görüldü (p<0,05). Ağrı skorlarında (p<0,001) ve fonksiyonel skorlarda (p<0,001) her 3 grupta da önemli gelişme vardı. Tedavi öncesi ve sonrası değerlendirildiğinde iki ve üç doz uygulana gruplar arasında istatistiksel anlamlı bir fark yoktu (p>0,05). Tek doz grubunun klinik ve fonksiyonel sonuçları diğer iki gruptan kötüydü (p<0,05). Sonuç: Tek doz PRP uygulamasının yeterli etkinliği sağlamadığı, bu sebeple tedavide uygun metodun en az 2 doz PRP uylaması olduğu kanaatindeyiz.

Keywords

• plateletten zengin plazma,PRP,diz,osteoartrit,doz,sıklık

The Effect of Platelet Rich Plasma Frequency On Early Stage Knee Osteoarthritis

Abstract

ABSTRACT Introduction: Platelet rich plasma (PRP) revealed quite satisfying results for early knee osteoarthritis (OA) especially in younger ages by decreasing pain and improving function and quality of life. However, what becomes the ideal dose and how often it should be performed, the effectiveness of intra-articular PRP application in different stages of OA are the main topics discussed. There are few studies in the literature comparing the efficacy of PRP with the administration dose. The primary aim of this study was to compare the efficacy of different doses of PRP in primary knee OA and to determine the ideal treatment modality. Material and methods: 174 patients who met the criteria were evaluated retrospectively between January 2016 and April 2017. The patients were divided into 3 groups according to doses. Western Ontario and McMaster University Arthritis Index (WOMAC) scores, International Knee Documentation Committee (IKDC) scores and 100 mm Visual Analogue Scale (100 mm VAS) scores were evaluated before treatment, 6 months and 12 months after treatment. Satisfaction status and treatment-related complications were examined at 12 months after treatment. Results: At the end of the follow-up, a significant improvement was observed in all three groups compared to the pre-treatment values. (p <0.05). Significant improvement was observed in pain scores (p <0.001) and functional scores (p <0.001) in all three injection groups. No significant difference was observed between twice or thrice applications (p >0.05). The clinical and functional results of one application was significantly lower than the other groups (p <0.05). Conclusion: We think that single dose therapy is less sufficient in effect, thus the appropriate method of treatment is at least 2 doses of PRP.

Keywords

• platelet rich plasma,PRP,Knee,osteoarthritis,dose,frequency

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