Abstract
Amaç: Karaciğer lipid metabolizmasında görev alan önemli bir organdır.
Biz bu çalışmamızda kronik karaciğer hastalığı olanlarda serum lipid
seviyelerindeki değişimin, Child-Pugh sınıflaması ve MELD skoru gibi prognostik
göstergelerle ilişkisini göstermeyi amaçladık.
Gereç ve Yöntem: Haziran
2010-Aralık 2015 tarihleri arasında Konya Eğitim ve Araştırma Hastanesi dahiliye
servisi ve yoğun bakım ünitesinde tedavi görüp, klinik ve laboratuvar olarak
kronik karaciğer parankim yetmezliği tanısı konulan toplam 161 hastanın dosyası
retrospektif olarak incelendi. Hastaların Child-Pugh skoru, MELD skoru ile lipid
düzeyleri karşılaştırıldı.
Bulgular: Dekompanse
sirozu olanlarda total kolesterol (p=0.006), HDL-kolesterol (p<0.001), VLDL-kolesterol
(p=0.027) ve trigliserid (p=0.028) düzeyleri kompanse sirozu olanlara göre
anlamlı düzeyde düşük saptandı. Child A’dan C’ye doğru evre arttıkça total
kolesterol (p=0.029) ve HDL kolesterol (p<0.001) düzeylerinde anlamlı azalma
saptandı. Hastaların MELD skoru arttıkça HDL- (p<0.001), LDL- (p=0.013) ve
total kolesterol (p=0.003) düzeylerinde anlamlı azalma saptandı.
Sonuç: Karaciğer
sirozlu hastalarda hastalığın derecesi arttıkça lipid düzeyleri azalmaktadır. Sonuç
olarak, düşük lipid düzeyleri karaciğer sirozunun şiddetini göstermede bir
belirteç olarak kullanılabilir.
References
- Dursun M, Karagöz A, Tuzcu A, et al. The Changes in the levels of Lipid and Lipoprotein in Liver Cirrhosis. Türkiye Klinikleri J Gastroenterohepatol 2003; 14: 133-138.
- Luo L, Pu X, Wang Y, Xu N. Impaired plasma lipid profiles in acute hepatitis. Lipids Health Dis. 2010, 9: 5.
- Taşçıoğlu C, Salmayenli N, Güler K, et al. Lipid Level Changes in Hepatic Cirrhosıs. T Klin Gastroenterohepatoloji. 1992; 3: 117-121
- Cicognani C, Malavolti M, Morselli-Labate AM, Zamboni L, Sama C, Barbara L. Serum lipid and lipoprotein patterns in patients with liver cirrhosis and chronic active hepatitis. Arch Intern Med. 1997; 157: 792-796.
- Selimoglu MA, Aydogdu S, Yagci RV. Lipid parameters in childhood cirrhosis and chronic liver disease. Pediatr Int. 2002; 44: 400-403
- Ghadir MR, Riahin AA, Havaspour A, Nooranipour M, Habibinejad AA. The relationship between lipid profile and severity of liver damage in cirrhotic patients. Hepat Mon. 2010; 10: 285-288.
- Kumar W, Harisha E. Assessment of lipid profile changes with respect to severity of liver dysfunction in cirrhosis of liver. IJBAMR. 2015; 4: 56-63.
- Bassani L, Fernandes SA, Raimundo FV, Harter DL, Gonzalez MC, Marroni CA. Lipid profile of cirrhotic patients and its association with prognostic scores: a cross-sectional study. Arq Gastroenterol. 2015; 52: 210-215.
- Chrostek L, Supronowicz L, Panasiuk A, Cylwik B, Gruszewska E, Flisiak R. The effect of the severity of liver cirrhosis on the level of lipids and lipoproteins. Clin Exp Med. 2014; 14: 417-421.
- Abbasi A, Bhutto AR, Butt N, Lal K, Munir SM. Serum cholesterol: could it be a sixth parameter of Child-Pugh scoring system in cirrhotics due to viral hepatitis?. J Coll Physicians Surg Pak. 2012; 22: 484-487.
- Subhan F. Khan I, Arif R, Khan A, Khan A. Serum Lipid profile as an indicator of severity of liver damage in cirrhotic patients. RMJ. 2012; 37:387-389.
- Habib A, Mihas AA, Abou-Assi SG, et al. High-density lipoprotein cholesterol as an indicator of liver function and prognosis in noncholestatic cirrhosis. Clin Gastroenterol Hepatol. 2005; 3:286–291.
Abstract
References
- Dursun M, Karagöz A, Tuzcu A, et al. The Changes in the levels of Lipid and Lipoprotein in Liver Cirrhosis. Türkiye Klinikleri J Gastroenterohepatol 2003; 14: 133-138.
- Luo L, Pu X, Wang Y, Xu N. Impaired plasma lipid profiles in acute hepatitis. Lipids Health Dis. 2010, 9: 5.
- Taşçıoğlu C, Salmayenli N, Güler K, et al. Lipid Level Changes in Hepatic Cirrhosıs. T Klin Gastroenterohepatoloji. 1992; 3: 117-121
- Cicognani C, Malavolti M, Morselli-Labate AM, Zamboni L, Sama C, Barbara L. Serum lipid and lipoprotein patterns in patients with liver cirrhosis and chronic active hepatitis. Arch Intern Med. 1997; 157: 792-796.
- Selimoglu MA, Aydogdu S, Yagci RV. Lipid parameters in childhood cirrhosis and chronic liver disease. Pediatr Int. 2002; 44: 400-403
- Ghadir MR, Riahin AA, Havaspour A, Nooranipour M, Habibinejad AA. The relationship between lipid profile and severity of liver damage in cirrhotic patients. Hepat Mon. 2010; 10: 285-288.
- Kumar W, Harisha E. Assessment of lipid profile changes with respect to severity of liver dysfunction in cirrhosis of liver. IJBAMR. 2015; 4: 56-63.
- Bassani L, Fernandes SA, Raimundo FV, Harter DL, Gonzalez MC, Marroni CA. Lipid profile of cirrhotic patients and its association with prognostic scores: a cross-sectional study. Arq Gastroenterol. 2015; 52: 210-215.
- Chrostek L, Supronowicz L, Panasiuk A, Cylwik B, Gruszewska E, Flisiak R. The effect of the severity of liver cirrhosis on the level of lipids and lipoproteins. Clin Exp Med. 2014; 14: 417-421.
- Abbasi A, Bhutto AR, Butt N, Lal K, Munir SM. Serum cholesterol: could it be a sixth parameter of Child-Pugh scoring system in cirrhotics due to viral hepatitis?. J Coll Physicians Surg Pak. 2012; 22: 484-487.
- Subhan F. Khan I, Arif R, Khan A, Khan A. Serum Lipid profile as an indicator of severity of liver damage in cirrhotic patients. RMJ. 2012; 37:387-389.
- Habib A, Mihas AA, Abou-Assi SG, et al. High-density lipoprotein cholesterol as an indicator of liver function and prognosis in noncholestatic cirrhosis. Clin Gastroenterol Hepatol. 2005; 3:286–291.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | Original Investigation |
| Authors | |
| Publication Date | September 10, 2018 |
| Acceptance Date | August 19, 2018 |
| Published in Issue | Year 2018 Volume: 1 Issue: 2 |
