Comparision of the Characteristics of Familial and Sporadic Cases in Patients with Gastric Cancer

Abstract

In this study, it was aimed to find the percentage of the non-familial and familial cases and comparison of their characteristic susing 2004 Canadian criteria in our cancer patients. The data from the files of 200 patients with histopathologically proven gastric cancer registered in our Medical Oncology Clinic were evaluated between January 2001 and December 2005. In our study, the ratio of familial cases is 10%. The mean ages of the patients are 56.44±0.78 in non-familial group and 53.30±2.90 in familial group. There were 113 males (62.77%), 67 females (37.23%) in non-familial group and 14 males (70%), 6 females (30%) in familial group. Histological types in familial and non-familial groups are; intestinal type 23.8% (n:3) and 75.23% (n:82); diffuse type 76.92% (n:10) and 24.77% (n:27) (p

Keywords

• Gastric cancer, familial, sporadic

Comparision of the Characteristics of Familial and Sporadic Cases in Patients with Gastric Cancer

Abstract

Bu çalışmada; mide kanserli hastalarımızda 2004 Kanada kriterleri göz önüne alınarak familiyal ve nonfamilyal vakaların oranının saptanması ve özelliklerinin karşılaştırılması amaçlandı. Ocak 2001 ile Aralık 2005 tarihleri arasında YYÜ Medikal Onkoloji Bilim Dalında poliklinik kayıdı olan histopatolojik tanısı konulmuş 200 mide kanserli hastanın dosya verileri değerlendirildi ve hasta ve/veya yakınları ile görüşüldü. Familyal özellik gösteren vaka oranı %10 oranında saptanmış olup hastaların yaş ortalamaları nonfamilyal grupta 56.44±0.78 yıl; familyal grupta 53.30±2.90 yıl olarak tespit edilmiştir. Nonfamilyal grupta 113 kişi (%62.77) erkek, 67 kişi (%37.23) kadın, familyal grupta 14 kişi (%70) erkek, 6 kişi (%30) kadın cinsiyette idi. Histolojik tipleri familyal ve nonfamilyal grupta sırasıyla %23.8 (n:3) ve %75.23 (n:82) intestinal tip; %76.92 (n:10) ve %24.77 (n:27) diffüz tip idi (p<0.01). Kanser evreleri familyal ve nonfamilyal vakalarda sırasıyla %5 (n:1) ve %26.67 (n:48) lokalize; %95 (n:19) ve %73.33 (n:132) ilerlemiş evredeydi (p<0.01). Helicobacterpylori (Hp) durumu; nonfamilyal grupta %9,38 (n=12) Hp negatif ve %90.62 (n:116) Hp pozitif; familyal grupta %100 (n:13) Hp pozitif idi (p<0.01). Kan grupları familyal ve nonfamilyal gruplarda sırasıyla %33.33 (n:2) ve %58.46 (n:38) A kan grubu; %16.67 (n:1) ve %10.77 (n:7) B kan grubu; %50 (n:3) ve %29.23 (n:19) O kan grubu idi. Nonfamilyal vakalarda %1.54 (n:1) AB kan grubu idi. Van yöresinde özellikle kırsal kesim şartlarında yaşayan insanlarda üst abdomen ile ilgili şikayetlerde endoskopik tarama ısrarla tavsiye edilmelidir

Keywords

• Mide kanseri, ailesel, sporadik

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