Comparision of the Characteristics of Familial and Sporadic Cases in Patients with Gastric Cancer

Öz

In this study, it was aimed to find the percentage of the non-familial and familial cases and comparison of their characteristic susing 2004 Canadian criteria in our cancer patients. The data from the files of 200 patients with histopathologically proven gastric cancer registered in our Medical Oncology Clinic were evaluated between January 2001 and December 2005. In our study, the ratio of familial cases is 10%. The mean ages of the patients are 56.44±0.78 in non-familial group and 53.30±2.90 in familial group. There were 113 males (62.77%), 67 females (37.23%) in non-familial group and 14 males (70%), 6 females (30%) in familial group. Histological types in familial and non-familial groups are; intestinal type 23.8% (n:3) and 75.23% (n:82); diffuse type 76.92% (n:10) and 24.77% (n:27) (p

Anahtar Kelimeler

• Gastric cancer, familial, sporadic

Comparision of the Characteristics of Familial and Sporadic Cases in Patients with Gastric Cancer

Öz

Bu çalışmada; mide kanserli hastalarımızda 2004 Kanada kriterleri göz önüne alınarak familiyal ve nonfamilyal vakaların oranının saptanması ve özelliklerinin karşılaştırılması amaçlandı. Ocak 2001 ile Aralık 2005 tarihleri arasında YYÜ Medikal Onkoloji Bilim Dalında poliklinik kayıdı olan histopatolojik tanısı konulmuş 200 mide kanserli hastanın dosya verileri değerlendirildi ve hasta ve/veya yakınları ile görüşüldü. Familyal özellik gösteren vaka oranı %10 oranında saptanmış olup hastaların yaş ortalamaları nonfamilyal grupta 56.44±0.78 yıl; familyal grupta 53.30±2.90 yıl olarak tespit edilmiştir. Nonfamilyal grupta 113 kişi (%62.77) erkek, 67 kişi (%37.23) kadın, familyal grupta 14 kişi (%70) erkek, 6 kişi (%30) kadın cinsiyette idi. Histolojik tipleri familyal ve nonfamilyal grupta sırasıyla %23.8 (n:3) ve %75.23 (n:82) intestinal tip; %76.92 (n:10) ve %24.77 (n:27) diffüz tip idi (p<0.01). Kanser evreleri familyal ve nonfamilyal vakalarda sırasıyla %5 (n:1) ve %26.67 (n:48) lokalize; %95 (n:19) ve %73.33 (n:132) ilerlemiş evredeydi (p<0.01). Helicobacterpylori (Hp) durumu; nonfamilyal grupta %9,38 (n=12) Hp negatif ve %90.62 (n:116) Hp pozitif; familyal grupta %100 (n:13) Hp pozitif idi (p<0.01). Kan grupları familyal ve nonfamilyal gruplarda sırasıyla %33.33 (n:2) ve %58.46 (n:38) A kan grubu; %16.67 (n:1) ve %10.77 (n:7) B kan grubu; %50 (n:3) ve %29.23 (n:19) O kan grubu idi. Nonfamilyal vakalarda %1.54 (n:1) AB kan grubu idi. Van yöresinde özellikle kırsal kesim şartlarında yaşayan insanlarda üst abdomen ile ilgili şikayetlerde endoskopik tarama ısrarla tavsiye edilmelidir

Anahtar Kelimeler

• Mide kanseri, ailesel, sporadik

Kaynakça

1. Tuncer I, Uygan I, Kosem M, Ozen S, Ugras S, Turkdogan K. Demographic and histopathologic features of Upper Gastrointestinal Cancer observed in Van region and sur- rounding areas. Van J Med 2001;8:1.
2. Alıcı S, Izmirli M, Dogan E. Epidemiologic evaluation of cancer patients admitted toYuzuncu Yıl UniversityFaculty of Medicine, Department of Medical Oncology. Turkish J Oncol 2006;2:87-97.
3. Sriamporn S, Setiawan V, Pisani P, et al. Gastric Cancer: the Roles of Diet, Alcohol Drinking, Smoking and Helicobacter pylori in Northeastern Thailand. Asian Pac J Cancer Prev 2002;3:345-52.
4. Roder DM. The epidemiology of gastric cancer. Gastric Cancer 2002;5:5-11.
5. Blair V, Martin I, Shaw D, et al. Hereditary diffuse gastric cancer: diagnosis and management. Clin Gastroenterol Hepatol 2006;4:262-75.
6. Suriano G, Yew S, Ferreira P, et al. Characterization of a recurrent germline mutation of the E-cadherin gene: implications for genetic testing and clinical management. Clin Cancer Res 2005;11:5401-9.
7. Guilford P, Hopkins J, Harraway J, et al. E-cadherin germline mutations in familial gastric cancer. Nature 1998;392:402-5.
8. Bacani JT, Soares M, Zwingerman R, et al. CDH1/E- cadherin germline mutations in early-onset gastric can- cer. J Med Genet 2006;43:867-72.

9. Turkdogan MK, Akman N, Tuncer I, et al. Epidemiological aspects of endemic upper gastrointestinal cancers in Eastern Turkey. Hepato-Gastroenterology 2005;52:496- 500.
10. Brooks-Wilson AR, Kaurah P, et al. Germline E-cadherin mutations in hereditary diffuse gastric cancer: assess- ment of 42 new families and review of genetic screening criteria. J Med Genet 2004;41:508-17.
11. Konturek JW. Discovery by Jaworski of Helicobacter pylori and its pathogenic role in peptic ulcer, gastritis and gas- tric cancer. J Physiol Pharmacol 2003;54:23-41.
12. Webb PM, Forman D. Helicobacter pylori as a risk factor for cancer. Baillieres Clin Gastroenterol 1995;9:563–82.
13. Jenab M, McKay JD, Ferrari P, et al. CDH1 gene poly- morphisms, smoking, Helicobacter pylori infection and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Eur J Cancer 2008;44:774-80.
14. Parsonnet J. The incidence of Helicobacter pylori infec- tion. Aliment Pharmacol Ther 1995;9:45-51.
15. You WC, Ma JL, Liu W, et al. Blood type and family cancer history in relation to precancerous gastric lesions. Int J Epidemiol 2000;29:405-7.
16. Barber M, Fitzgerald RC, Caldas C. Familial gastric cancer– aetiology and pathogenesis. Gastric Cancer 2006;20:721-34.
17. Hemminki K, JiangY. Familial and second gastric carci- nomas: A Nation wide epidemiologic study from Sweden. Cancer 2002;94:1157-65.
18. Pedrazzani C, Corso G, Marrelli D, Roviello F. E-cadherin and hereditary diffuse gastric cancer. Surgery 2007;142:645-57.
19. Graziano F, Humar B, Guilford P. The role of the E-cadherin gene (CDH1) in diffuse gastric cancer suscepti- bility: from the laboratory to clinical practice. Ann Oncol 2003;14:1705–13.
20. Chen JD, Kearns S, Porter T, Richards FM, Maher ER, Teh BT. MET mutation and familial gastric cancer. J Med Genet 2001;38:26.
21. Hohenberger P, Gretschel S. Gastric cancer. Lancet 2003;362:305-15.