CLINICAL SIGNIFICANCE OF PREOPERATIVE SERUM IL-6 LEVELS IN GASTRIC CARCINOMA WITH LYMPH NODE METASTASIS

Abstract

Keywords

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CLINICAL SIGNIFICANCE OF PREOPERATIVE SERUM IL-6 LEVELS IN GASTRIC CARCINOMA WITH LYMPH NODE METASTASIS

Öz

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Anahtar Kelimeler

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References

1. Stacker SA, Caesar C, Baldwin ME, et al. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat Med 2001;7:186-91.
2. Mandriota SJ, Jussila L, Jeltsch M, et al. vascular endothelial growth factor-C mediated lymphangiogenesis promotes tumor metastasis. EMBO J 2001;20:672-82.
3. Skobe M, Hawighorst T, Jackson DG, et al. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med 2001;7:192-8.
4. Choi JH, Oh YH, Park YW, Baik HK, Lee YY, Kim S. Correlation of VEGF-D expression and VEGFR3-positive vessel density with lymph node metastasis in gastric carcinoma. J Korean Med Sci 2008 23(4):592-7.
5. Cohen T, Nahari D, Cerem LW, Neufeld G, Levi BZ. IL-6 induces the expression of vascular endothelial growth factor. J Biol Chem 1996;27(2):736-41.
6. Thong-Ngam D, Tangkijvanich P, Lerknimitr R, Mahachi V, Theamboonlers A, Poorawan Y. Diagnostic role of serum interleukin-18 in gastric cancer patients. World J Gastroenterology 2006;12(28):4473-7.
7. To KF, Chan MW, Leung WK, et al. Constitutional activation of IL-6-mediated JAK/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell line. Br J Cancer 2004;91(7):1335-41.
8. Watanabe S, Mu W, Kahn A, et al. Role of JAK/STAT pathway in IL-6-induced activation of vascular endothelial smooth muscle cells. Am J Nephrol 2004;24(4):387-92.

9. Rawlings JS, Rosler KM, Harrison DA. The JAK/STAT signaling pathway. J Cell Sci 2004;117 (Pt 8):1281-3.
10. Heinrich PC, Behrmann I, Haan S, et al. Principles of IL6-type cytokine signaling and its regulation. Biochem J 2003;374(Pt 1):1-20.
11. Lin MT, Lin BR, Chang CC, et al. IL-6 induces AGS gastric cancer cell invasion via activation of the c-Src/RhoA/Rock signaling pathway. Int J Cancer 2007;120(12):2600-8.
12. Liao WC, Lin JT, Wu CY, et al. Serum IL-6 level but not genotype predicts survival after resection in stages II and III gastric carcinoma. Clin Cancer Res 2008;14(2):428-34.
13. Ashizawa T, Okada R, Suzuki Y, et al. Clinical significance of IL-6 in the spread of gastric cancer: role of IL-6 as a prognostic factor. Gastric Cancer 2008;8(2):124-31.
14. Chung YC, Chang YF. Serum IL-6 levels reflect the disease status of colorectal cancer. J Surg Oncol 2003;83(4):2226.
15. Huang SP, Wu MS, Wang HP, Yang CS, Kuo ML, Lin JT. Correlation between serum levels of IL-6 and VEGf in gastric carcinoma. J Gastroenterol Hepatol 2002;17(11):11659.
16. Nikiteas NI, Tzanakis N, Gazouli M, et al. Serum IL-6, TNFalpha and CRP levels in Greek colorectal cancer patients: prognostic implications. World J Gastroenterol 2005; 11(11):1639-43.