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Comparison of the Postoperative Analgesic Effects of Wound Infiltration with Tramadol and Levobupivacaine in Children Undergoing Inguinal Hernia and Undescended Testis Surgery

Year 2013, Volume: 10 Issue: 2, 74 - 78, 01.06.2013

Abstract

The aim of this study was to compare the effects of wound infiltration with levobupivacaine and tramadol in reducing postoperative pain in children undergoing unilateral inguinal hernia and undescended testis surgery. Under general anesthesia for elective unilateral inguinal hernia and undescended testis underwent surgery, ASA I-II, 80 children between the ages of 1-6 records in the patient's file was reviewed. The patients who were given 2mg.kg-1 tramadol in saline solution as prepared 0,2 ml.kg-1 into the surgical incision area by the surgeon at the end of the operation were accepted as Group T, who were given 0.25% levobupivacaine as 0.2 ml.kg-1 were accepted as Group L. Hemodynamic parameters, CHEOPS pain scores, additional analgesic consumption, adverse effects were recorded from the files. Patients\' CHEOPS were significantly higher in Group L compared to Group T at 4 and 6 hours (p

References

  • Rawal N, Axelsson K, Hylander J, et al. Postoperative patient controlled local anesthetics administration at home. Anesth Analg 1998; 86:86-9.
  • Gristwood RW. Cardiac and CNS toxicity of levobupiva- caine: strengths of evidence for advantage over bupiva- caine. Drug Saf 2002;25:153-63.
  • Burlacu CL, Buggy DJ. Update on local anesthetics: fo- cus on levobupivacaine. Ther Clin Risk Manag 2008; 4 (2): 381-92
  • Matsota P, Papageorgiou-Brousta M, Kostopanagiotou G. Wound infiltration with levobupivacaine: an alternative method of postoperative pain relief after inguinal hernia repair in children. Eur J Pediatr Surg 2007;17(4):270-4.
  • Bay-Nielsen M, Klarskov B, Bech K, Andersen J, Kehlet H. Levobupivacaine and bupivacaine as infiltration anaesthe- sia in inguinal herniorrhaphy.Br J Anaesth 1999; 82:280-2
  • Jaffe RA, Rowe MA. A comparison of the local anesthetic effects of meperidine, fentanyl, and sufentanil on dorsal root axons. Anesth Analg 1996; 83: 776–81.
  • Mert T, Gunes Y, Guven M, Gunay I, Ozcengiz D. Comparison of nerve conduction blocks by an opioid and a local anesthetic. Eur J Pharmacol 2002;439:77–81.
  • Altunkaya H, Ozer Y, Kargi E, et al. The postoperative analgesic effect of tramadol when used as subcutaneous local anesthetic. Anesth Analg 2004;99:1461–4.
  • Khajavi MR, Aghili SB, Moharari RS, et al. Subcutaneous tramadol infiltration at the wound site versus intravenous administration after pyelolithotomy. Ann Pharmacother 2009;43(3):430-5.
  • Ugur MB, Yilmaz M, Altunkaya H, Cinar F, Ozer Y, Beder L. Effects of intramuscular and peritonsillar injection of tra- madol before tonsillectomy: a double blind, randomized, placebo-controlled clinical trial. Int J Otorhinolaryngol 2008;72(2):241-8.
  • Kaki AM, Al Marakbi W. Post-herniorrhapy infiltration of tramadol versus bupivacaine for postoperative pain re- lief: a randomized study. Ann Saudi Med 2008;28(3):165-8
  • McGrath PJ, Johnson G, Goodman JT, et al. In: Fields HL, Dubner R, Cervero F, editors. The CHEOPS. A Behavioural Scale to Measure Postoperative Pain in Children. New York, USA: Raven Press; 1985. p. 395-402.
  • Covino BG, Wildsmith JAW. Clinical pharmacology of local anesthetic agents. In Cousins MJ, Bridenbaugh PO, eds. Neuronal Blockade. 3rd. Ed. Philadelphia: Lippincott- Raven, 1998. p.107
  • Cınar SO, Kum U, Cevizci N, Kayaoglu S, Oba S. Effects of levobupivacaine infiltration on postoperative analgesia and stress response in children following inguinal hernia repair. Eur J Anaesthesiology 2009;26:430–43
  • Ellmauer S, Dick W, Otto S, Müller H. Different opioids in patients at cardiovascular risk. Comparison of central and peripheral hemodynamic adverse effects. Anaesthesist 1994;43(11):743-9
  • Pang WW, Huang PY, Chang DP, Huang MH. The peripheral analgesic effect of tramadol in reducing propofol injec- tion pain: a comparison with lidocaine. Reg Anesth Pain Med 1999;24:246–9.
  • Pang WW, Mok MS, Chang DP, Yang TF, Lin CH, Huang MH. Intradermal injection of tramadol has local anesthetic ef- fect: a comparison with lidocaine. Acta Anaesthesiol Sin 1998;36:133–6.
  • Tsai YC, Chang PJ, Jou IM. Direct tramadol application on sciatic nerve inhibits spinal somatosensory evoked poten- tials in rats. Anesth Analg 2001;92:1547–51.
  • Demiraran Y, Ilce Z, Kocaman B, Bozkurt P. Does tramadol wound infiltration offer an advantage over bupivacaine for postoperative analgesia in children following herni- otomy? Pediatric Anesthesia 2006;16:1047–50
  • Radbruch L, Grond S, Lehmann KA. A risk–benefit assess- ment of tramadol in the management of pain. Drug Saf 1996;15:8– 29.
  • Shipton EA. Tramadol: present and future. Anesth Intensive Care 2000;28:363–74.

Comparison of the Postoperative Analgesic Effects of Wound Infiltration with Tramadol and Levobupivacaine in Children Undergoing Inguinal Hernia and Undescended Testis Surgery

Year 2013, Volume: 10 Issue: 2, 74 - 78, 01.06.2013

Abstract

Biz çalışmamızda inguinal herni ve inmemiş testis operasyonu geçiren çocuklarda levobupivakain ile tramadolun yara yeri infiltrasyon yöntemiyle postoperatif ağrıyı azaltmadaki etkinliklerini karşılaştırmayı amaçladık. Genel anestezi altında elektif inguinal herni ve inmemiş testis operasyonu geçiren, ASA I-II risk grubunda, 1-6 yaş arası 80 çocuk hastanın dosya kayıtları retrospektif olarak incelendi. Cerrahi bitiminde, cilt kapanmadan önce yara dudaklarına 2 mg/kg tramadol içeren solusyondan 0.2 ml/kg olacak şekilde yapılanlar T Grubu, %0.25’ lik levobupivakain solusyondan 0.2 ml/kg olacak şekilde yapılanlar L Grubu olarak kabul edildi. Hemodinamik parametreler, CHEOPS ağrı skoru, ek analjezik tüketimi ve yan etkiler dosyalardan incelenerek kaydedildi.Hastaların CHEOPS skoru L grubunda T grubu ile kıyaslandığında 4. ve 6. saatte daha yüksek saptandı (p<0.01). Ek analjezik tüketimi bakımından, Grup T’de ev periyodu dönemi parasetamol tüketimi Grup L 'den daha düşüktü (p<0.05). Sonuç olarak biz çalışmamızda; inguinal herni onarımı ve inmemiş testis operasyonu geçiren çocuklarda yara yerine infiltre edilen tramadolun levobupivakaine göre daha uzun analjezi süresi sağladığını ve ek analjezik ihtiyacının daha az olduğunu bulduk

References

  • Rawal N, Axelsson K, Hylander J, et al. Postoperative patient controlled local anesthetics administration at home. Anesth Analg 1998; 86:86-9.
  • Gristwood RW. Cardiac and CNS toxicity of levobupiva- caine: strengths of evidence for advantage over bupiva- caine. Drug Saf 2002;25:153-63.
  • Burlacu CL, Buggy DJ. Update on local anesthetics: fo- cus on levobupivacaine. Ther Clin Risk Manag 2008; 4 (2): 381-92
  • Matsota P, Papageorgiou-Brousta M, Kostopanagiotou G. Wound infiltration with levobupivacaine: an alternative method of postoperative pain relief after inguinal hernia repair in children. Eur J Pediatr Surg 2007;17(4):270-4.
  • Bay-Nielsen M, Klarskov B, Bech K, Andersen J, Kehlet H. Levobupivacaine and bupivacaine as infiltration anaesthe- sia in inguinal herniorrhaphy.Br J Anaesth 1999; 82:280-2
  • Jaffe RA, Rowe MA. A comparison of the local anesthetic effects of meperidine, fentanyl, and sufentanil on dorsal root axons. Anesth Analg 1996; 83: 776–81.
  • Mert T, Gunes Y, Guven M, Gunay I, Ozcengiz D. Comparison of nerve conduction blocks by an opioid and a local anesthetic. Eur J Pharmacol 2002;439:77–81.
  • Altunkaya H, Ozer Y, Kargi E, et al. The postoperative analgesic effect of tramadol when used as subcutaneous local anesthetic. Anesth Analg 2004;99:1461–4.
  • Khajavi MR, Aghili SB, Moharari RS, et al. Subcutaneous tramadol infiltration at the wound site versus intravenous administration after pyelolithotomy. Ann Pharmacother 2009;43(3):430-5.
  • Ugur MB, Yilmaz M, Altunkaya H, Cinar F, Ozer Y, Beder L. Effects of intramuscular and peritonsillar injection of tra- madol before tonsillectomy: a double blind, randomized, placebo-controlled clinical trial. Int J Otorhinolaryngol 2008;72(2):241-8.
  • Kaki AM, Al Marakbi W. Post-herniorrhapy infiltration of tramadol versus bupivacaine for postoperative pain re- lief: a randomized study. Ann Saudi Med 2008;28(3):165-8
  • McGrath PJ, Johnson G, Goodman JT, et al. In: Fields HL, Dubner R, Cervero F, editors. The CHEOPS. A Behavioural Scale to Measure Postoperative Pain in Children. New York, USA: Raven Press; 1985. p. 395-402.
  • Covino BG, Wildsmith JAW. Clinical pharmacology of local anesthetic agents. In Cousins MJ, Bridenbaugh PO, eds. Neuronal Blockade. 3rd. Ed. Philadelphia: Lippincott- Raven, 1998. p.107
  • Cınar SO, Kum U, Cevizci N, Kayaoglu S, Oba S. Effects of levobupivacaine infiltration on postoperative analgesia and stress response in children following inguinal hernia repair. Eur J Anaesthesiology 2009;26:430–43
  • Ellmauer S, Dick W, Otto S, Müller H. Different opioids in patients at cardiovascular risk. Comparison of central and peripheral hemodynamic adverse effects. Anaesthesist 1994;43(11):743-9
  • Pang WW, Huang PY, Chang DP, Huang MH. The peripheral analgesic effect of tramadol in reducing propofol injec- tion pain: a comparison with lidocaine. Reg Anesth Pain Med 1999;24:246–9.
  • Pang WW, Mok MS, Chang DP, Yang TF, Lin CH, Huang MH. Intradermal injection of tramadol has local anesthetic ef- fect: a comparison with lidocaine. Acta Anaesthesiol Sin 1998;36:133–6.
  • Tsai YC, Chang PJ, Jou IM. Direct tramadol application on sciatic nerve inhibits spinal somatosensory evoked poten- tials in rats. Anesth Analg 2001;92:1547–51.
  • Demiraran Y, Ilce Z, Kocaman B, Bozkurt P. Does tramadol wound infiltration offer an advantage over bupivacaine for postoperative analgesia in children following herni- otomy? Pediatric Anesthesia 2006;16:1047–50
  • Radbruch L, Grond S, Lehmann KA. A risk–benefit assess- ment of tramadol in the management of pain. Drug Saf 1996;15:8– 29.
  • Shipton EA. Tramadol: present and future. Anesth Intensive Care 2000;28:363–74.
There are 21 citations in total.

Details

Primary Language English
Journal Section Original Articles
Authors

Bahanur Cekic This is me

Ufuk Dogan This is me

Sukran Geze This is me

Engin Erturk This is me

Ahmet Besir This is me

Publication Date June 1, 2013
Published in Issue Year 2013 Volume: 10 Issue: 2

Cite

APA Cekic, B., Dogan, U., Geze, S., Erturk, E., et al. (2013). Comparison of the Postoperative Analgesic Effects of Wound Infiltration with Tramadol and Levobupivacaine in Children Undergoing Inguinal Hernia and Undescended Testis Surgery. European Journal of General Medicine, 10(2), 74-78.
AMA Cekic B, Dogan U, Geze S, Erturk E, Besir A. Comparison of the Postoperative Analgesic Effects of Wound Infiltration with Tramadol and Levobupivacaine in Children Undergoing Inguinal Hernia and Undescended Testis Surgery. European Journal of General Medicine. June 2013;10(2):74-78.
Chicago Cekic, Bahanur, Ufuk Dogan, Sukran Geze, Engin Erturk, and Ahmet Besir. “Comparison of the Postoperative Analgesic Effects of Wound Infiltration With Tramadol and Levobupivacaine in Children Undergoing Inguinal Hernia and Undescended Testis Surgery”. European Journal of General Medicine 10, no. 2 (June 2013): 74-78.
EndNote Cekic B, Dogan U, Geze S, Erturk E, Besir A (June 1, 2013) Comparison of the Postoperative Analgesic Effects of Wound Infiltration with Tramadol and Levobupivacaine in Children Undergoing Inguinal Hernia and Undescended Testis Surgery. European Journal of General Medicine 10 2 74–78.
IEEE B. Cekic, U. Dogan, S. Geze, E. Erturk, and A. Besir, “Comparison of the Postoperative Analgesic Effects of Wound Infiltration with Tramadol and Levobupivacaine in Children Undergoing Inguinal Hernia and Undescended Testis Surgery”, European Journal of General Medicine, vol. 10, no. 2, pp. 74–78, 2013.
ISNAD Cekic, Bahanur et al. “Comparison of the Postoperative Analgesic Effects of Wound Infiltration With Tramadol and Levobupivacaine in Children Undergoing Inguinal Hernia and Undescended Testis Surgery”. European Journal of General Medicine 10/2 (June 2013), 74-78.
JAMA Cekic B, Dogan U, Geze S, Erturk E, Besir A. Comparison of the Postoperative Analgesic Effects of Wound Infiltration with Tramadol and Levobupivacaine in Children Undergoing Inguinal Hernia and Undescended Testis Surgery. European Journal of General Medicine. 2013;10:74–78.
MLA Cekic, Bahanur et al. “Comparison of the Postoperative Analgesic Effects of Wound Infiltration With Tramadol and Levobupivacaine in Children Undergoing Inguinal Hernia and Undescended Testis Surgery”. European Journal of General Medicine, vol. 10, no. 2, 2013, pp. 74-78.
Vancouver Cekic B, Dogan U, Geze S, Erturk E, Besir A. Comparison of the Postoperative Analgesic Effects of Wound Infiltration with Tramadol and Levobupivacaine in Children Undergoing Inguinal Hernia and Undescended Testis Surgery. European Journal of General Medicine. 2013;10(2):74-8.