Evaluation of hepatoprotective activity of Bergamot orange in rats

Abstract

Abstract. Essential oil extract of Bergamot orange (BO) was investigated for its hepatoprotective effect on carbon tetrachloride-induced hepatotoxicity in rats. Six different groups were established. Silibinin was used as the reference agent. BO significantly reduced the serum ALT level when compared to CCl₄ group while it did not affect the serum AST level. The histopathological findings did not show any significant difference between the BO and CCl₄ groups. The results suggest that BO has a weak hepatoprotective effect in carbon tetrachloride induced acute liver toxicity.

Keywords: Bergamot orange, hepatoprotective activity, carbon tetrachloride, rats.

Keywords

• Bergamot orange, hepatoprotective activity, carbon tetrachloride, rats

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