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Hypothalamic hamartoma presenting with gelastic seizures and precocious puberty: Report of a case

Year 2010, Volume: 15 Issue: 2, 67 - 70, 16.01.2013

Feroze Shaheen Aijaz Hakim Maqbool Wani Rauf Asmi

Abstract

Abstract. Hypothalamic hamartoma is a rare condition and usually presents with precocious puberty. Clinical manifestation as gelastic seizures is less common and combined presentation as gelastic seizures and precocious puberty is even less frequent. Being a treatable condition, prompt diagnosis is important. offers precise diagnosis in most cases.

Key words:  Hypothalamic hamartoma, gelastic seizures, precocious puberty, MRI

Keywords

Hypothalamic hamartoma gelastic seizures precocious puberty MRI

References

  • Hahn FJ, Leibrock LG, Huseman CA, Makos MM. The MR appearance of hypothalamic hamartoma. Neuroradiology 1988; 30: 65-68.
  • Munari C, Kahane P, Francione S et al. Role of the hypothalamic hamartoma in the genesis of gelastic fits (avideo-stereo-EEG study). Electroencephalogr Clin Neurophysiol 1995; 95: 154-160.
  • Northfield DW. Russell DS Pubertas praecox due to hypothalamic hamartoma: report of two cases surviving surgical removal of the tumor. J. Neurol Neurosurg Psychiatry 1967; 30: 166-173.
  • Karnaze MG, Sartor K, Winthrop JD, Gado MH, Hodges FJ. 3rd. Suprasellar lesions: evaluation with MR imaging. Radiology 1986; 161: 77-82.
  • Freeman JL, Coleman LT, Wellard RM, et al. MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases. AJNR Am J Neuroradiol 2004; 25: 450-62.
  • Tasch F, Candes F, Li LM. Hypothalamic hamartoma and gelastic epilepsy: a spectroscopic study. Neurology 1998; 51: 1046-1050.
  • Barkovich AJ. Intracranial, orbital and neck tumors of childhood: Pediatric Neuroimaging- Philadelphia Lippincot and Wilkins 2000: 443- 580.
  • Lona Soto A, Takahashi M, Yamashita Y, Sakamoto Y, Shinzato J. MRI findings of hypothalamic hamartoma; report of five cases and review of literature. Comput Med Imaging Graph 1991; 15:15-21.
  • Marliani AF, Tampieri D, Melancon D, Ethier R, Berkovic SF, Andermann F. Magnetic Resonance Imaging of hypothalamic hamartoma causing gelastic epilepsy. Can Assoc. Radiol J 1991; 42: 335-339.
  • de Brito VN, Latronico AC, Arnhold IJ, Lo LS. Domenice S. Treatment of gonadotrophin dependent precocious puberty due to hypothalamic hamartoma with gonadotrophin releasing harmone agonist depot. Arch Dis Child 1999; 80: 231-234.
  • Gascon GG, Lumbroso CT. Epileptic laughter Epilepsia 1971; 12: 63-76.
  • Biraben A, Sartori E, Tausig D, Bernard AM, Scarabin JM. Gelastic seizures: video EEG and scintigraphic analysis of a case with a frontal lobe focus;a review of literature and pathophysiological hypothesis. Epileptic Disorders 1999; 1: 221-227.
  • Striano S, Meo R, Bilo L. Gelastic epilepsy: Symptomatic and cryptogenic cases. Epilepsia 1999; 40: 294-302.
  • Kahane P, Munari C, Minotti L. The role of hypothalamic hamartoma in the genesis of gelastic and dacrystic seizures. In Tuxhan I, Holthausen H, Boenigk K eds. Paediatric epilepsy syndromes and their surgical treatment, London ; John Libby 1997: 447-461.
  • Freeman JL, Harwey AS, Rosenfeld JV, Wrennal JA, Bailey CA. Generalised epilepsy in hypothalamic hamartoma : evolution and post operative resolution. Neurology 2003; 60: 762- 767.
  • Striano S, Striano P, Cirillo S, et al. Small hypothalamic hamartomas and gelastic seizures. Epileptic disorders 2002; 4: 129-133.
  • Palmini A, Paglioti-Neto E, Montes J, Farmer JP. The treatment of patients with hypothalamic hamartoma, epilepsy and behavioral abnormalities: facts and hypotheses. Epilep Disord 2003; 5: 249- 255.
  • Téllez-Zenteno JF, Serrano-Almeida C, Moien- Afshari F. Gelastic seizures associated with hypothalamic hamartomas. An update in the clinical presentation, diagnosis and treatment. Neuropsychiatr Dis Treat 2008; 4: 1021-1031.
  • Choi JU, Yang KH, Kim TG, et al. Endoscopic disconnection for hypothalamic hamartoma with intractable seizure. Report of four cases. J Neurosurg 2004; 100 (5 Suppl Pediatrics): 506- 511.
  • Kuzniecky R, Guthrie B, Knowlton R, Faught F. M. İnvasive surgical management of hypothalamic hamartomas in gelastic epilepsy. Epilepsia 2002; 43 (Suppl 7): s34-s38.
  • Fukuda M, Kamayama S, Wachi M, Tanaka R. Stereotaxy for hypothalamic hamartoma with intractable gelastic seizures: technical case report. Neurosurgery 1999; 44: 1347-1350.
  • Schulze-Bonhage A, Trippel M, Wagner K, Bast T.Diemling FV. Outcome and predictors of interstitial radio surgery in treatment of gelastic epilepsy. Neurology 2008; 71: 277-282.
  • Regis J, Scarvarda D, Tamura M. Gamma knife surgery for epilepsy related to hypothalamic hamartoma. Semin Pediatr Neurol 2007; 14: 73-79.
  • Regis J, Bartolomei F, de Toffol B. Gamma knife surgery for epilepsy related to hypothalamic hamartomas. Neurosurgery 2000; 47: 1343-1352.

Year 2010, Volume: 15 Issue: 2, 67 - 70, 16.01.2013

Feroze Shaheen Aijaz Hakim Maqbool Wani Rauf Asmi

Abstract

References

  • Hahn FJ, Leibrock LG, Huseman CA, Makos MM. The MR appearance of hypothalamic hamartoma. Neuroradiology 1988; 30: 65-68.
  • Munari C, Kahane P, Francione S et al. Role of the hypothalamic hamartoma in the genesis of gelastic fits (avideo-stereo-EEG study). Electroencephalogr Clin Neurophysiol 1995; 95: 154-160.
  • Northfield DW. Russell DS Pubertas praecox due to hypothalamic hamartoma: report of two cases surviving surgical removal of the tumor. J. Neurol Neurosurg Psychiatry 1967; 30: 166-173.
  • Karnaze MG, Sartor K, Winthrop JD, Gado MH, Hodges FJ. 3rd. Suprasellar lesions: evaluation with MR imaging. Radiology 1986; 161: 77-82.
  • Freeman JL, Coleman LT, Wellard RM, et al. MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases. AJNR Am J Neuroradiol 2004; 25: 450-62.
  • Tasch F, Candes F, Li LM. Hypothalamic hamartoma and gelastic epilepsy: a spectroscopic study. Neurology 1998; 51: 1046-1050.
  • Barkovich AJ. Intracranial, orbital and neck tumors of childhood: Pediatric Neuroimaging- Philadelphia Lippincot and Wilkins 2000: 443- 580.
  • Lona Soto A, Takahashi M, Yamashita Y, Sakamoto Y, Shinzato J. MRI findings of hypothalamic hamartoma; report of five cases and review of literature. Comput Med Imaging Graph 1991; 15:15-21.
  • Marliani AF, Tampieri D, Melancon D, Ethier R, Berkovic SF, Andermann F. Magnetic Resonance Imaging of hypothalamic hamartoma causing gelastic epilepsy. Can Assoc. Radiol J 1991; 42: 335-339.
  • de Brito VN, Latronico AC, Arnhold IJ, Lo LS. Domenice S. Treatment of gonadotrophin dependent precocious puberty due to hypothalamic hamartoma with gonadotrophin releasing harmone agonist depot. Arch Dis Child 1999; 80: 231-234.
  • Gascon GG, Lumbroso CT. Epileptic laughter Epilepsia 1971; 12: 63-76.
  • Biraben A, Sartori E, Tausig D, Bernard AM, Scarabin JM. Gelastic seizures: video EEG and scintigraphic analysis of a case with a frontal lobe focus;a review of literature and pathophysiological hypothesis. Epileptic Disorders 1999; 1: 221-227.
  • Striano S, Meo R, Bilo L. Gelastic epilepsy: Symptomatic and cryptogenic cases. Epilepsia 1999; 40: 294-302.
  • Kahane P, Munari C, Minotti L. The role of hypothalamic hamartoma in the genesis of gelastic and dacrystic seizures. In Tuxhan I, Holthausen H, Boenigk K eds. Paediatric epilepsy syndromes and their surgical treatment, London ; John Libby 1997: 447-461.
  • Freeman JL, Harwey AS, Rosenfeld JV, Wrennal JA, Bailey CA. Generalised epilepsy in hypothalamic hamartoma : evolution and post operative resolution. Neurology 2003; 60: 762- 767.
  • Striano S, Striano P, Cirillo S, et al. Small hypothalamic hamartomas and gelastic seizures. Epileptic disorders 2002; 4: 129-133.
  • Palmini A, Paglioti-Neto E, Montes J, Farmer JP. The treatment of patients with hypothalamic hamartoma, epilepsy and behavioral abnormalities: facts and hypotheses. Epilep Disord 2003; 5: 249- 255.
  • Téllez-Zenteno JF, Serrano-Almeida C, Moien- Afshari F. Gelastic seizures associated with hypothalamic hamartomas. An update in the clinical presentation, diagnosis and treatment. Neuropsychiatr Dis Treat 2008; 4: 1021-1031.
  • Choi JU, Yang KH, Kim TG, et al. Endoscopic disconnection for hypothalamic hamartoma with intractable seizure. Report of four cases. J Neurosurg 2004; 100 (5 Suppl Pediatrics): 506- 511.
  • Kuzniecky R, Guthrie B, Knowlton R, Faught F. M. İnvasive surgical management of hypothalamic hamartomas in gelastic epilepsy. Epilepsia 2002; 43 (Suppl 7): s34-s38.
  • Fukuda M, Kamayama S, Wachi M, Tanaka R. Stereotaxy for hypothalamic hamartoma with intractable gelastic seizures: technical case report. Neurosurgery 1999; 44: 1347-1350.
  • Schulze-Bonhage A, Trippel M, Wagner K, Bast T.Diemling FV. Outcome and predictors of interstitial radio surgery in treatment of gelastic epilepsy. Neurology 2008; 71: 277-282.
  • Regis J, Scarvarda D, Tamura M. Gamma knife surgery for epilepsy related to hypothalamic hamartoma. Semin Pediatr Neurol 2007; 14: 73-79.
  • Regis J, Bartolomei F, de Toffol B. Gamma knife surgery for epilepsy related to hypothalamic hamartomas. Neurosurgery 2000; 47: 1343-1352.
There are 24 citations in total.

Details

Primary Language English
Authors

Feroze Shaheen This is me

Aijaz Hakim This is me

Maqbool Wani This is me

Rauf Asmi This is me

Publication Date January 16, 2013
Published in Issue Year 2010 Volume: 15 Issue: 2

Cite

APA Shaheen, F., Hakim, A., Wani, M., Asmi, R. (2013). Hypothalamic hamartoma presenting with gelastic seizures and precocious puberty: Report of a case. EASTERN JOURNAL OF MEDICINE, 15(2), 67-70.
AMA Shaheen F, Hakim A, Wani M, Asmi R. Hypothalamic hamartoma presenting with gelastic seizures and precocious puberty: Report of a case. EASTERN JOURNAL OF MEDICINE. March 2013;15(2):67-70.
Chicago Shaheen, Feroze, Aijaz Hakim, Maqbool Wani, and Rauf Asmi. “Hypothalamic Hamartoma Presenting With Gelastic Seizures and Precocious Puberty: Report of a Case”. EASTERN JOURNAL OF MEDICINE 15, no. 2 (March 2013): 67-70.
EndNote Shaheen F, Hakim A, Wani M, Asmi R (March 1, 2013) Hypothalamic hamartoma presenting with gelastic seizures and precocious puberty: Report of a case. EASTERN JOURNAL OF MEDICINE 15 2 67–70.
IEEE F. Shaheen, A. Hakim, M. Wani, and R. Asmi, “Hypothalamic hamartoma presenting with gelastic seizures and precocious puberty: Report of a case”, EASTERN JOURNAL OF MEDICINE, vol. 15, no. 2, pp. 67–70, 2013.
ISNAD Shaheen, Feroze et al. “Hypothalamic Hamartoma Presenting With Gelastic Seizures and Precocious Puberty: Report of a Case”. EASTERN JOURNAL OF MEDICINE 15/2 (March2013), 67-70.
JAMA Shaheen F, Hakim A, Wani M, Asmi R. Hypothalamic hamartoma presenting with gelastic seizures and precocious puberty: Report of a case. EASTERN JOURNAL OF MEDICINE. 2013;15:67–70.
MLA Shaheen, Feroze et al. “Hypothalamic Hamartoma Presenting With Gelastic Seizures and Precocious Puberty: Report of a Case”. EASTERN JOURNAL OF MEDICINE, vol. 15, no. 2, 2013, pp. 67-70.
Vancouver Shaheen F, Hakim A, Wani M, Asmi R. Hypothalamic hamartoma presenting with gelastic seizures and precocious puberty: Report of a case. EASTERN JOURNAL OF MEDICINE. 2013;15(2):67-70.