Rhabdomyolysis and acute renal failure

Abstract

Abstract. Bentazone (Basagran®) is a commonly used and easily available agricultural herbicide. We report a 41-year-old-man who developed rhabdomyolysis with acute renal failure after bentazone toxicity. Four hours later after oral intake of liquid bentazone for suicidal attempt, the patient admitted to emergency service and his initial renal function tests were in normal range. However on the 15^th hour of intake, urine output decreased, and blood urine nitrogen, creatinine and creatinine kinase levels were increased. On the fifth day of hospitalization, creatinine and creatinine kinase levels had turned to normal levels. As a result, bentazone intoxication may cause rhabdomyolysis with acute renal failure. Thus, renal functions must be followed up closely.

 

Key words: Bentazone intoxication; rhabdomyolysis; acute renal failure

Keywords

• Bentazone intoxication, rhabdomyolysis, acute renal failure

References

1. Budavari S. The Merck Index ± an Encyclopedia of Chemicals, Drugs and Biologicals, ed 12. Merck Research Laboratories, Division of Merck & Co., Inc., Whitehouse Station, NJ, USA, 1996; 176.
2. Neuschl J, Kacmar P. Acute oral toxicity of bentazon, an herbicide developed in Czechoslovakia, in pheasants and rabbits and the clinical symptoms of poisoning. Vet Med 1993; 38: 115-121.
3. Bentazone in drinking-water. WHO guidelines for Drinking water. http://www.cepis.ops- oms.org/bvsacg/e/cdcagua/guias/b.parametos/3.RefB /quimicos/012.Bentazone/012b-bentazone.pdf
4. Lin TJ, Hung DZ, Hu WH, Yang DY, Wu TC. Acute basagran poisoning mimicking neuroleptic malignant syndrome. Hum Exp Toxicol 1999; 18: 493-494.
5. Thomas MA, Ibels LS. Rhabdomyolysis and acute renal failure. Aust N Z J Med 1985; 15: 623-628.
6. Iitsuka T, Koyama A, Kobayashi M, et al. Acute renal failure due to rhabdomyolysis clinical investigation on our six cases. Nippon Jinzo Gakkai Shi 1992; 34: 317-324.
7. Müller IB, Willads Petersen H, Johansen SS, Theilade P. Fatal overdose of the herbicide bentazone. Forensic Sci Int 2003; 135: 235-236.
8. Turcant A, Harry P, Cailleux A, et al. Fatal acute poisoning by bentazon. J Anal Toxicol 2003; 27: 113-117.

9. Wu IW, Wu MS, Lin JL. Acute renal failure induced by bentazone: 2 case reports and a comprehensive review. J Nephrol 2008; 21: 256-260.
10. Neuschl J, Kacmar P, Legath J, Tomas J. The effect of Bentazone, a Czechoslovak developmental herbicide, on health status indicators in sheep during subchronic poisoning. Vet Med 1992; 37: 161-167.
11. Huber R, Otto S. Environmental behavior of
12. bentazon herbicide. Rev Environ Contam Toxicol 1994; 137: 111-134.