Effect of ZnO nanoparticles on ESBL producing Escherichia coli & Klebsiella spp.

Abstract

Abstract. Zinc oxide (ZnO) nanaoparticles have been observed to have significant antibacterial properties against different gram positive and gram negative organisms. This study was done to determine the effect ZnO nanoparticles against ESBL producing organisms. Which are acting as menance in treatment of severe infective conditions. ZnO nanoparticles were tested against ESBL producing E.coli and Klebsiella. Inhibition of growth was observed by spectrophotometry. There was significant reduction in growth of ESBL positive isolates of E.coli and Klebsiella. Thus nanoparticles have a potential to be used as antibacterial agents in case of infections with ESBL positive organisms, which can be cause of high mortality and morbidity.

Key words: Nanoparticle, extended spectrum β- lactamase (ESBL), Klebsiella

Keywords

• Nanoparticle, extended spectrum β- lactamase (ESBL), Klebsiella

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