Can agricultural drugs be used against lice? accident, suicide or truth? case presentations

Abstract

 

Abstract. Agriculture is an important source of living in our country. Therefore, poisoning with agricultural drugs is quite common. 4,6 dinitro-ocresol nitrophenol (C₇H₆N₂O₅) is a pesticide, which belongs to the nitrophenol group, is used on fruit trees in winter and is known as the “yellow” drug among the public. In our country, intoxication with nitrophenols has not been reported previously in the literature. However, they may be lethal even by dermal route. This rare type of intoxication should be recognized and kept in mind by physicians. A careful and detailed history should be taken in all cases of intoxication and the treatment should be based on the type of intoxication. The aim of the present study is to evaluate 5 cases of serious toxicity that occurred accidentally and/or because the drug was applied on hair for anti-louse purposes in our region, where agriculture and breeding animals are important sources of life.

 

Key words: Agricultural drugs, pesticides, nitrophenol, suicide, accident

 

 

 

Keywords

• Agricultural drugs, pesticides, nitrophenol, suicide, accident

References

1. Evalution of the toxicity of pesticide residues in food. DNOC: www.inchem.org/documents /jmpr/jmpmono/v065pr14.htm (Access date:21.04.2008).
2. DNOC (4,6-DINITRO-o-CRESOL): www.epa.gov/ttn/atw/hlthef/di-creso.html (Access date: 25.01.2011).
3. Hsiao AL, Santucci KA, Seo-Mayer P, et al. Pediatric fatality following ingestion of dinitrophenol: postmortem identification of a "dietary supplement". Clin Toxicol (Phila) 2005; 43: 281-285.
4. Dinitro-o-cresol: http://ces.iisc.ernet.in/energy/HC270799/HDL/ENV/ enven/vol335.htm. (Access date: 25.01.2011).
5. Nitrophenolic and Nitrocresolic Herbicides:http://www.docstoc.com/docs/7810099/1 1 (Access date: 21.08.2008).
6. Goksu S, Yildirim C, Kocoğlu H, Tutak A, Oner U. Characteristics of acute adult poisoning in Gaziantep, Turkey. J Toxicol Clin Toxicol 2002; 40: 833-837.
7. Pekdemir M, Yıldız M, Durukan P, Kavalcı C. Acil servise başvuran erişkin zehirlenme olgularının prospektif olarak incelenmesi. Toksikoloji dergisi 2004; 2: 41-49.
8. Takahashi KL, Hojo H, Aoyama H, Teramoto S. Comparative studies on the spermatotoxic effects of dinoseb and its structurally related chemicals. Reprod Toxicol 2004; 18: 581-588.

9. Macnab AJ, Fielden SJ. Successful treatment of dinitrophenol poisoning in a child. Pediatr Emerg Care 1998; 14: 136-138.
10. Leftwich RB, Floro JF, Neal RA, Wood AJ. Dinitrophenol poisoning: a diagnosis to consider in undiagnosed fever. South Med J 1982; 75: 182-184.
11. Miranda EJ, mcıntyre IM, Parker DR, Gary RD, Logan BK. Two deaths attributed to the use of 2,4- dinitrophenol. J Anal Toxicol 2006; 30: 219-222.
12. Palmeira CM, Moreno AJ, Madeira VM. Thiols metabolism is altered by the herbicides paraquat, dinoseb and 2,4-D: a study in isolated hepatocytes. Toxicol Lett 1995; 81: 115-123.
13. McFee RB, Caraccio TR, McGuigan MA, Reynolds SA, Bellanger P. Dying to be thin: a dinitrophenol related fatality. Vet Hum Toxicol 2004; 46: 251-254.
14. Robey WC, Meggs WJ. Insecticides, herbicides, rodenticides. Tintinalli JE, Kalen GD, Stapczynski ÜS. Emergency Medicine. 6th ed. New York; Mcgraw-Hill Companies 2004; 1134-1143.