 Determination of lethal doses of volatile and fixed oils of several plants

Abstract

Objective: To determine lethal doses of fixed and/or
volatile oils extracted from leafs or fruits of Pimpinella
anisum, Foeniculum vulgare, Sesamum indicum,
Eugenia caryophyllata, Nigella sativa, Urtica pilulifera,
Apium graveolens, Cuminum cyminum, Coriandrum
sativum and Thymus fallax.
Method:   Swiss albino mice were injected
intraperitoneally with different concentrations of the
extract and results were evaluated with the method of
probit analysis.
Results: Maximum volume of oil administered to mice
was kept below 0.5 ml. The oils of Sesamum indicum
and Urtica pilulifera was completely non-lethal even at
doses reaching 12.8 ml/kg and considered non-toxic.
Conclusion: Lethal doses were determined for all other
plants and LD1, LD10, LD50, LD90 and LD99 values were
given.
Key words: Volatile oil, fixed oil, lethal doses, plants

Keywords

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