US and CT findings of Hibernoma in an unusual location

Abstract

Hibernomas are asymptomatic, slow-growing tumors occurring in the anatomical sites where of brown fatty tissue was found in fetal life such as inter-scapular region or thigh. Retroperitoneal localization is an unusual site for this tumor and only few cases have been published in the literature. These tumors are benign in nature without any recurrence after total excision or evidence of metastasis. The purpose of this presentation is to demonstrate the US and CT findings of retroperitoneal hibernoma with the review of the literature.

Keywords

• Hibernoma
• brown fat tissue
• retroperitoneal space

References

1. Merkel H. Ubereinpseudolipoma der Mama (elgenartigerFettzellen tumor). Beitr Pathol Anat Alleg Pathol 1906; 39: 152-157.
2. Grey L. Discussions. Bull Mem Soc Anat (Paris) 1914; 00: 111-112.
3. Murphey MD, Carroll JF, Flemming DJ, et al. From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics 2004; 24: 143314
4. Drevelegas A, Pilavaki M, Chourmouzi D. Lipomatous tumors of soft tissue: MR appearance with histological correlation. Eur J Radiol 2004; 50: 257-2
5. Bancroft LW, Kransdorf MJ, Peterson JJ, O'Connor MI. Benign fatty tumors:classification clinical course imaging appearance and treatment. Skeletal Radiol 2006; 35: 719-733.
6. Stephen AH, Sanjay RP, John WB. Hibernoma of the pericardium presenting as pericardial effusion in a child. Ped Pathol 1990; 10: 575-580.
7. Fletcher CDM, Cole RS, Gower RL, Heyderman E. Hibernoma of the spermatic cord: the first reported case. Br J Urol 1986; 58: 99-100.
8. Gulmez I, Dogan A, Balkanlı S, et al. The first case of periureterichibernoma. Scand J Urol Nephrol 1996; 31: 203-204.

9. Muszynski CA, Robertson DP, Goodman JC, Baskin DS. Scalp hibernoma: Case report and literature review. Surg Neurol 1994; 42: 343-345.
10. Chitoku S, Kawai S, Watebe Y, et al. Intradural spinal hibernoma: Case report. Surg Neurol 1998; 49: 509-513.
11. Furlong MA, Fanburg-Smith JC, Miettinen M. The morphologic spectrum of hibernoma: a clinicopathologic study of 170 cases. Am J Surg Pathol 2001; 25: 809-814.
12. Cantisani V, Mortele KJ, Glickman JN, et al. Large retroperitoneal hibernoma in an adult male: CT imaging findings with pathologic correlation. Abdom Imaging 2003; 28: 721-724.
13. Yohannan J, Feng T, Allaf ME. Retroperitoneal hibernoma in a 28-year-old man. Urology 2011; 78: 320-3
14. Dursun M, Agayev A, Bakir B, et al. CT and MR characteristics of hibernoma: six cases. Clin Imaging 2008; 32: 42-47.
15. Alvine G, Rosenthal H, Murphey M, Huntrakoon M. Hibernoma. Skeletal Radiol 1996; 25: 493-496. Rigor VU, Goldstone SE, Jones J, et al. Hibernoma: a case report and discussion of a rare tumor. Cancer 1986; 57: 2207-2211.
16. Gaffney EF, Hargreaves HK, Semple E, Vellios F. Hibernoma: distinctive light and electron microscopic features and relationship to Brown adipose tissue. Hum Pathol 1983; 14: 677-687. Lele MS, Chundru S, Chaljub G, Adegboyega P, Haque AK. Hibernoma.A Report of 2 Unusual Cases with a Review of the Literature. Arch Pathol Lab Med 2002; 126: 975-978.
17. Lowry WSB, Halmos PB. Malignant tumor of Brown fat in a patient with Turner’s Synrome. Br Med J 1967; 4: 720-721.
18. Enterline HT, Lowry LD, Richman AV. Does malignant hibernoma exist? Am J Surg Pathol 1979; 3: 265-271.
19. Teplitz C, Farrugia R, Glicksman AS. Malignant hibernoma does exist (abstract). Lab Invest 1980; 42: 154-155. Kallas KM, Vaughan L, Haghighi P, Resnick D. Hibernoma of the left axilla; a case report and review of MR imaging. Skeletal Radiol 2003; 32: 290-2