Ileo-colic intussusception following oral polio vaccination: A mere coincidence or morbid consequence

Abstract

Abstract. The National polio surveillance programme is one ofthe prime health projects in Nepaland its neighboring countries. A huge amount of effort and money is beingpumped into polio surveillance in these areas. Vaccine associated Paralyticpolio is one of the prime concerns as far as the side effects are considered.In the past there has been concern over the relationship of Oral Polio Vaccine(OPV) with intussusception as with rotavirus vaccine. We report a case ofileo-colic intussusception which occurred within 24 hours of oral poliovaccination during the pulse polio immunisation. We also discuss the factsavailable to us regarding the association of OPV with intussusception.Key words: Oral polio vaccine, intussusception

Keywords

• Oral polio vaccine, intussusception

References

1. Intussusception among recipients of rotavirus vaccine-United States, 1998-1999. MMWR Morb Mortal Wkly Rep 1999; 48: 577-581.
2. Withdrawal of rotavirus vaccine recommendation. MMWR Morb Mortal Wkly Rep 1999; 48: 1007. Oral poliovirus vaccine (OPV) and intussusception. Wkly Epidemiol Rec 2000; 75: 345-347.
3. Jick H, Vasilakis-Scaramozza C, Jick SS. Live attenuated polio vaccine and the risk of intussusception. Br J Clin Pharmacol 2001; 52: 4514
4. Andrews N, Miller E, Waight P, et al. Does oral polio vaccine cause intussusception in infants? Evidence from a sequence of three self-controlled cases series studies in the United Kingdom. Eur J Epidemiol 2001; 17: 701-706.
5. Li ST, Davis RL, Weiss NS. Intussusception and oral poliovirus vaccination: is there an association? Am J Epidemiol 2004; 160: 576-581.
6. Sardiñas MA, Cárdenas AZ, Marie GC, et al. Lack of association between intussusception and oral polio vaccine in Cuban children. Eur J Epidemiol 2001; 17: 783-787.
7. Raman T, Mukhopadhyaya A, Eapen CE, et al. Intussusception in southern Indian children: lack of association with diarrheal disease and oral polio vaccine immunization. Indian J Gastroenterol 2003; 22: 82-84.
8. J. Claire Cameron, David Walsh, Alan R. Finlayson, James H. Boyd. Oral Polio Vaccine and Intussusception: A Data Linkage Study using Records for Vaccination and Hospitalization. Am J Epidemiol 2006; 163: 528-533.

9. Paul Y. OPV may be discontinued but for a different reason. Ind Ped 2006; 43: 1005-1006.