Descriptive epidemiology of Non-Hodgkin’s lymphomas in Hatay

Abstract

Abstract. The incidence of Non-Hodgkin’s Lymphomas (NHL) varies among different parts of the world. NHL are the 12th most common cancer in Europe and increasing dramatically during the last years. In this study, it was aimed to analyse the descriptive epidemiology of NHL in Hatay region with retrospective archieve datas. One hundred and thirty-three NHL cases between 2005 and 2013 have been reviewed retrospectively in the Pathology Department of the Mustafa Kemal University. All of the cases were classified according to World Health Organization modified in 2008. Eighty-two (61.7%) cases were male and 51 (38.3%) cases were female. Ninety-two of the cases (69.2%) were nodal lymphoma, and the remaining 41 (30.8%) were extranodal lymphoma. The most common extranodal involvement regions were tonsils and nasopharynx with frequencies of 21.9% (9) and 19.5% (8), respectively. The age distribution pattern revealed that NHL were mostly diagnosed in the ages of 41-65 years in nodal (41.3%) and extranodal sited NHL groups (53.6%). The most frequent NHL was diffuse large cell B cell lymphoma (50.4%) and chronic lymphocytic leukemia/small lymphocytic lymphoma (17.3%). Our results were similar with the literature. Further epidemiologic studies with larger series defining the profile of NHL subtypes may be more worthy. Key words: Non-Hodgkin’s lymphoma, histologic subtype, extranodal involvement, descriptive epidemiology

Keywords

• Non-Hodgkin’s lymphoma, histologic subtype, extranodal involvement, descriptive epidemiology

References

1. Greiner TC, Medeiros LJ, Jaffe ES. Non-Hodgkin’s lymphoma. Cancer 1995; 75: 370-380.
2. Ho FCS, Todd D, Loke SL, Ng RP, Khoo RKK. Clinicopathologic features of malignant lymphomas in 294 Hong Kong Chinese patients, retrospective study covering an eight year period. Int J Cancer 1984: 34: 143-148.
3. Anderson JR, Armittage JO, Weisenburger DD. Epidemiology of the non-Hodgkin’s lymphomas: distribution of the major subtypes differ by geographic locations. Non-Hodgkin Lymphoma Classification Project. Ann Oncol 1998; 9: 717-720.
4. Shih LY, Liang DC. Non-Hodgkin’s lymphomas in Asia. Hematol Oncol Clin North Am 1991; 5: 983100
5. Novelli S, Briones J, Sierra J. Epidemiology of lymphoid malignencies: last decade update. Springerplus 2013; 2: 70.
6. Sinha R, Nastoupil L, Flowers CR. Treatment strategies for patients with Diffuse Large B-Cell Lymphoma: Past, Present and Future. Blood Lymphat Cancer 2012: 87-98.
7. Walter PR, Klotz F, Alfy-Gattaz T, Minko-mi-etoua D, Nguenbi-Mbina C. Malign lymphomas in Gabon (Equatorial Africa): a morphological study of 72 cases. Hum Pathol 1991; 22: 1040-1043.
8. Cool CD, Bitter MA. The malignant Lymphomas of Kenya: Morphology, Immunophenotype, and frequency of Ebstein Barr virus in 73 cases. Human Pathology 1997; 28: 1026-1033.

9. Naresh KN, Srinivas V, Soman CS. Distribution of various subtypes of non-Hodgkin’s lymphoma in India: a study of 2773 lymhomas using R.E.A.L. and WHO classifications. Ann Oncol 2000; 11: 63-67.
10. Yilmaz F, Arslan A, Uzunlar AK, et al. NonHodgkin Lymphomas in Southeastern Anatolia. Erciyes Tıp Dergisi 1999; 21: 95-103.
11. Kilciksiz S, Payzin B, Caglar BU, et al. Evaluation of Standard prognostic factors according to age cutoff values (60 years and 50 years) and peak age in our non-Hodgkin’s lymphomas patients. Turkish J Oncol 2006; 21: 11-19.
12. Lopez-Guillermo A, Colomo L, Jimenez M, et al. Diffuse large B cell lymphoma: clinical and biological charecterization and outcome according to the nodal or extranodal primary origin. J Clin Oncol 2005; 23: 2797-2804.
13. Isıkdogan A, Ayyildiz O, Buyukcelik A, et al. NonHodgkin’s lymphoma in southeast Turkey: clinicopathologic features of 490 cases. Ann Hematol 2004; 83: 265-269.
14. Walter PR, Klotz F, Alfy Gattas T, Minko-Mi-Etoua D, Nguembi-Mbina C. Malignant lymphomas in Gabon (equatorial Africa): a morphologic study of 72 cases. Hum Pathol 1991; 22: 1040-1043.
15. Raemaekers JN, Snoeijen JJ, Bogman MJ, et al. Prognostic significance of the histologic classification and staging for patients with a malignant non-Hodgkin lymphoma. Ned-TijdschrGeneeskd 1993; 137: 815-820.
16. Lieberman PH, Filippa PA, Straus DJ. Evaluation of malignant lymphomas using three classification and the Working Formulation. Am J Med 1986; 81: 3653
17. Omoti CE, Nwannadi AI, Obieche JC, Olu-Eddo AN. The epidemiological features of lymphoid malignencies in Benin city, Nigeria: a 15 years study. Pan Afr Med J 2012; 11: 10.
18. Uncu D, Ozdemir N, Karakan S, Oksuzoglu BC, Zengin N. Primer extranodal lenfomalar: Klinik özelliklerinin nodal lenfomalarla karşılaştırılması. THOD 2005; 15: 63-67.
19. Zucca E, Cavalli F. Extranodal lymphomas. Ann Oncol 2000; 11: 219-222.
20. Arican A, Dincol D, Akbulut H, et al. Primer extranodal lenfomalar. Hematoloji-Onkoloji 2000; 2: 273-2
21. Essadi I, Ismaili N, Tazi E, et al. Primary lymphoma of the head and neck: two case reports and review of the literature. Cases J 2008; 1: 426.
22. Shenkier TN, Connors JM. Primary extranodal nonHodkin’s lymphomas. In: Canellos GP, Lister TA, Young BD (eds). The lymphomas (2nd ed). Philadelphia: Saunders Elsevier, 2006, pp 325-347.