The effect of antibiotherapy used against the PSA increase in serum PSA levels

Abstract

Aim.To evaluatethe effect of antibiotics in patients with PSA value high than 4 ng / ml ontPSA, fPSA and fPSA / tPSA ratio.Methods.A total of96 patients  included the study withdetected high level than 4 ng / ml serum PSA. Patients were divided into 2groups according to the high level of PSA value. Group 1 included 49 patients with PSA level between 4-10ng/ml. Group 2 included 47 patients with PSA level high than 10 ng/ml. Patientswere treated with  Ciprofloxacin (500mgb.i.d.) orally for 2 weeks. All patients' PSA levels  were evaluated and analyzed before and afterantibiotic treatment. Statistical analyses were performed with SPSS version 18.A p value <0.05 was considered significant.Results.The meanage was 61.6 ±5.7 (51-75) years in group 1 and 63.1 ±8.7 (55-74) years in group2. Suspicious DRE findings were significantly high  in group 2. The mean tPSA values were6.82±0.42 and 5.93±0.36 before and after antibiotic treatment in group 1respectively. There was no significant differences tPSA value before and afterantibiotic treatment in group 1.  Themean tPSA values were 32.53±8.23 and 11.72±5.61 before and after antibiotictreatment in group 2 respectively. The mean tPSA value decreased significantlyafter antibiotic treatment in group 2. Prostate cancer was detected in 32 patients after TRUS guided prostatebiopsy.  Prostate cancer was identifiedin 13 patients in gruop 1 and 19 patients in group 2. Conclusıons.Antibiotic treatment in patients with PSA levels high than 10 ng/ml iseffective on prostate biopsy decision and antibiotic treatment can preventunnecessary prostate biopsies.

Keywords

• Prostate, cancer, PSA, biopsy

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