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Year 2005, Volume: 10 Issue: 1-2, 1 - 4, 20.03.2013

Abstract

References

  • Gürkan E, Öndersev DV, Ulusoylu M, Göztaş Z, Dinçşahin N: Phytotherapy. Istanbul-Turkey, Marmara Univ Publishing, 2003.
  • Cum G, Kunkar C Kunkar A: Supercritical CO2 extraction of Citrus Bergamia Risso oil. Proceedings of the 9th Smposium on Plant Drugs, 16-9 May 1991, Turkey.
  • Tisserand R: The Art of Aromatherapy. Chapter Ed: C.W. Daniel, Essex, 1977.
  • Graham PH, Browne L, Cox H, Graham J: Inhalation aromatherapy during radiotherapy: results of a placebo-controlled double-blind randomized trial. J Clin Oncol 2000;21(12): 2372- 2376.
  • Zacher KD, Ippen H: Contact dermatitis caused by bergamot oil. Derm Beruf Umwelt 1984;32(3): 95- 97.
  • Kaddu S, Kerl H, Wolf P: Accidental bullous phototoxic reactions to bergamot aromatherapy oil. J Am Acad Dermatol 2001;45(3): 458-461.
  • Weisenseel P, Woitalla S: Toxic mustard plaster dermatitis and phototoxic dermatitis after application of bergamot oil. MMW Fortschr Med 2005;147(51-52): 53-55.
  • Romano L, Battaglia F, Masucci L, Sanguinetti M, Posteraro B, Plotti G, Zanetti S, Fadda G: In vitro activity of bergamot natural essence and furocoumarin-free and distilled extracts, and their associations with boric acid, against clinical yeast isolates. J Antimic Chem 2005;55(1): 110-114.
  • Sanguinetti M, Posteraro B, Romano L, Battaglia F, Lopizzo T, De Carolis E, Fadda G: In vitro activity of Citrus bergamia (bergamot) oil against clinical isolates of dermatophytes. J Antimicrob Chemother 2006 (In press).
  • Fisher K, Phillips CA: The effect of lemon, orange and bergamot essential oils and their components on the survival of Campylobacter jejuni, Escherichia coli O157, Listeria monocytogenes, Bacillus cereus and Staphylococcus aureus in vitro and in food systems. J Appl Microbiol 2006;101(6): 1232-1240.
  • Devi KP, Sreepriya M, Balakrishna K, Devaki T: Protective effect of Premna tomentosa extract (L. verbanacae) on acetaminophen-induced mitochondrial dysfunction in rats. Mol Cell Biochem 2005;272(1-2): 171-177.
  • Devi KP, Sreepriya M, Balakrishna K, Devaki T: Protective effect of Premna tomentosa (L. Verbenaceae) extract on membrane-bound phosphatases and inorganic cations transport in acetaminophen-induced hepatotoxicity rats. J Ethnopharmacol 2004;93(2-3): 371-375.
  • Özbek H, Bayram İ, Cengiz N, Uğraş S: Evaluation of Foeniculum vulgare compunds of Lethal Dose Levels and Hepatoprotective Effects. Turkish Pharmacological Society 18th National Pharmacology Congress, September 2005, Izmir- Turkey, S40.
  • Lershin BI: Experimental pharmacotherapy of toxic hepatitis. Pathol Physiol Ther 1971;13: 66- 67.
  • Handa SS, Sharma A: Hepatoprotective activity of andrographolide from Andrographis paniculata against carbontetrachloride. Indian J Med Res [B] 1990;92: 276-283.
  • Horváth MÉ, González-Cabello R, Blázovics A, Looij M, Barta I, Müzes G, Gergely P, Fehér J: Effect of silibinin and vitamin E on restoration of cellular immune response after partial hepatectomy. J Ethnopharmacol 2001;77: 227-232.
  • Imren AH, Turan O: Laboratory Tests in Clinical Diagnosis. 3rd ed. Beta Press, 1985, Istanbul- Turkey, p: 230-231.

Evaluation of hepatoprotective activity of Bergamot orange in rats

Year 2005, Volume: 10 Issue: 1-2, 1 - 4, 20.03.2013

Abstract

Abstract. Essential oil extract of Bergamot orange (BO) was investigated for its hepatoprotective effect on carbon tetrachloride-induced hepatotoxicity in rats. Six different groups were established. Silibinin was used as the reference agent. BO significantly reduced the serum ALT level when compared to CCl4 group while it did not affect the serum AST level. The histopathological findings did not show any significant difference between the BO and CCl4 groups. The results suggest that BO has a weak hepatoprotective effect in carbon tetrachloride induced acute liver toxicity.

Keywords: Bergamot orange, hepatoprotective activity, carbon tetrachloride, rats.

References

  • Gürkan E, Öndersev DV, Ulusoylu M, Göztaş Z, Dinçşahin N: Phytotherapy. Istanbul-Turkey, Marmara Univ Publishing, 2003.
  • Cum G, Kunkar C Kunkar A: Supercritical CO2 extraction of Citrus Bergamia Risso oil. Proceedings of the 9th Smposium on Plant Drugs, 16-9 May 1991, Turkey.
  • Tisserand R: The Art of Aromatherapy. Chapter Ed: C.W. Daniel, Essex, 1977.
  • Graham PH, Browne L, Cox H, Graham J: Inhalation aromatherapy during radiotherapy: results of a placebo-controlled double-blind randomized trial. J Clin Oncol 2000;21(12): 2372- 2376.
  • Zacher KD, Ippen H: Contact dermatitis caused by bergamot oil. Derm Beruf Umwelt 1984;32(3): 95- 97.
  • Kaddu S, Kerl H, Wolf P: Accidental bullous phototoxic reactions to bergamot aromatherapy oil. J Am Acad Dermatol 2001;45(3): 458-461.
  • Weisenseel P, Woitalla S: Toxic mustard plaster dermatitis and phototoxic dermatitis after application of bergamot oil. MMW Fortschr Med 2005;147(51-52): 53-55.
  • Romano L, Battaglia F, Masucci L, Sanguinetti M, Posteraro B, Plotti G, Zanetti S, Fadda G: In vitro activity of bergamot natural essence and furocoumarin-free and distilled extracts, and their associations with boric acid, against clinical yeast isolates. J Antimic Chem 2005;55(1): 110-114.
  • Sanguinetti M, Posteraro B, Romano L, Battaglia F, Lopizzo T, De Carolis E, Fadda G: In vitro activity of Citrus bergamia (bergamot) oil against clinical isolates of dermatophytes. J Antimicrob Chemother 2006 (In press).
  • Fisher K, Phillips CA: The effect of lemon, orange and bergamot essential oils and their components on the survival of Campylobacter jejuni, Escherichia coli O157, Listeria monocytogenes, Bacillus cereus and Staphylococcus aureus in vitro and in food systems. J Appl Microbiol 2006;101(6): 1232-1240.
  • Devi KP, Sreepriya M, Balakrishna K, Devaki T: Protective effect of Premna tomentosa extract (L. verbanacae) on acetaminophen-induced mitochondrial dysfunction in rats. Mol Cell Biochem 2005;272(1-2): 171-177.
  • Devi KP, Sreepriya M, Balakrishna K, Devaki T: Protective effect of Premna tomentosa (L. Verbenaceae) extract on membrane-bound phosphatases and inorganic cations transport in acetaminophen-induced hepatotoxicity rats. J Ethnopharmacol 2004;93(2-3): 371-375.
  • Özbek H, Bayram İ, Cengiz N, Uğraş S: Evaluation of Foeniculum vulgare compunds of Lethal Dose Levels and Hepatoprotective Effects. Turkish Pharmacological Society 18th National Pharmacology Congress, September 2005, Izmir- Turkey, S40.
  • Lershin BI: Experimental pharmacotherapy of toxic hepatitis. Pathol Physiol Ther 1971;13: 66- 67.
  • Handa SS, Sharma A: Hepatoprotective activity of andrographolide from Andrographis paniculata against carbontetrachloride. Indian J Med Res [B] 1990;92: 276-283.
  • Horváth MÉ, González-Cabello R, Blázovics A, Looij M, Barta I, Müzes G, Gergely P, Fehér J: Effect of silibinin and vitamin E on restoration of cellular immune response after partial hepatectomy. J Ethnopharmacol 2001;77: 227-232.
  • Imren AH, Turan O: Laboratory Tests in Clinical Diagnosis. 3rd ed. Beta Press, 1985, Istanbul- Turkey, p: 230-231.
There are 17 citations in total.

Details

Primary Language English
Journal Section Articles
Authors

Mehmet Karaca This is me

Fatma İlhan This is me

Hasan Altan This is me

Aydın Him This is me

Mehmet Tütüncü This is me

Hanefi Özbek This is me

Publication Date March 20, 2013
Published in Issue Year 2005 Volume: 10 Issue: 1-2

Cite

APA Karaca, M., İlhan, F., Altan, H., Him, A., et al. (2013). Evaluation of hepatoprotective activity of Bergamot orange in rats. EASTERN JOURNAL OF MEDICINE, 10(1-2), 1-4.
AMA Karaca M, İlhan F, Altan H, Him A, Tütüncü M, Özbek H. Evaluation of hepatoprotective activity of Bergamot orange in rats. EASTERN JOURNAL OF MEDICINE. March 2013;10(1-2):1-4.
Chicago Karaca, Mehmet, Fatma İlhan, Hasan Altan, Aydın Him, Mehmet Tütüncü, and Hanefi Özbek. “Evaluation of Hepatoprotective Activity of Bergamot Orange in Rats”. EASTERN JOURNAL OF MEDICINE 10, no. 1-2 (March 2013): 1-4.
EndNote Karaca M, İlhan F, Altan H, Him A, Tütüncü M, Özbek H (March 1, 2013) Evaluation of hepatoprotective activity of Bergamot orange in rats. EASTERN JOURNAL OF MEDICINE 10 1-2 1–4.
IEEE M. Karaca, F. İlhan, H. Altan, A. Him, M. Tütüncü, and H. Özbek, “Evaluation of hepatoprotective activity of Bergamot orange in rats”, EASTERN JOURNAL OF MEDICINE, vol. 10, no. 1-2, pp. 1–4, 2013.
ISNAD Karaca, Mehmet et al. “Evaluation of Hepatoprotective Activity of Bergamot Orange in Rats”. EASTERN JOURNAL OF MEDICINE 10/1-2 (March 2013), 1-4.
JAMA Karaca M, İlhan F, Altan H, Him A, Tütüncü M, Özbek H. Evaluation of hepatoprotective activity of Bergamot orange in rats. EASTERN JOURNAL OF MEDICINE. 2013;10:1–4.
MLA Karaca, Mehmet et al. “Evaluation of Hepatoprotective Activity of Bergamot Orange in Rats”. EASTERN JOURNAL OF MEDICINE, vol. 10, no. 1-2, 2013, pp. 1-4.
Vancouver Karaca M, İlhan F, Altan H, Him A, Tütüncü M, Özbek H. Evaluation of hepatoprotective activity of Bergamot orange in rats. EASTERN JOURNAL OF MEDICINE. 2013;10(1-2):1-4.