Abstract
Abstract: The anti-inflammatory activity of the extract of Vernonia amygdalina was investigated. Inflammatory response was induced by topical application of croton oil dissolved in suitable vehicle on the rat ear. After 6 hrs, cutting out the ear quantitated the response. The cut ear is weighed and the increase in weight relative to controls evaluated. Extract of V.amygdalina when co-applied with croton oil to the rat ear produced a reduction in the inflammatory response produced when croton oil alone was applied to the rat ear. The extract produced 67.10 + 2% reduction of the inflammatory response produced by croton oil alone, this was however lower than the 71.1 + 2% reduction of the inflammatory response produced by acetyl salicylic acid. This finding suggests that extract of V. amygdalina exhibits anti-inflammatory activity and may explain the usefulness of the leaves of this plant in the treatment of inflammatory disease conditions by traditional healers.
Key words: Inflammatory response, croton oil, acetyl salicylic acid, Vernonia amygdali
References
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- Serhan CN, Takano T, Maddox JF. Aspirin triggered lipoxin A4 and stable analogs of lipoxin A4 are potent inhibitors of acute inflammation. Receptors and pathways. Adv Exp Med Biol 1999; 447: 133-149.
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- Branbaifa N, Georgewill OA. A quantitative assessment of topical antiphilogistic potencies of corticosteroids and non steroids. Medipharm Med J 1987; 1: 10-13.
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Abstract
References
- Vane I, Bottling R. Inflammation and the mechanism of action of anti-inflammatory drugs. FASEB J 1987; 1: 89-96.
- Serhan CN, Takano T, Maddox JF. Aspirin triggered lipoxin A4 and stable analogs of lipoxin A4 are potent inhibitors of acute inflammation. Receptors and pathways. Adv Exp Med Biol 1999; 447: 133-149.
- Rao BN, Anderson MB, Mussea JH, Gilbert JH. Sialyl Lewis X mimic derived from a pharmacophore search are selective inhibitors with anti-inflammatory activity. Biol Chem 1994; 269: 19663-19666.
- Famaey, JP. Phospholipases, Eicosanoid production and inflammation (Review). Clin Rheumatol 1982; 1: 2008-211.
- Toneli G, Thuboult L, inler I. A bioassay for the concomitant assessment of antiphilogistic and thymolytic activities of topically applied corticosteroids. Endocrinology 1965; 77: 625-634.
- Bailey CJ, Day C. Traditional treatment for Diabetes. Diabetes Care 1989; 12: 553-564.
- Nwokoro EA, Nwanjo HU. Antidiabetic and biochemical effects of extract of Vernonia amygdalina in diabetic rats. J.Innov Life Sci 2004; 7: 6-10.
- Branbaifa N, Georgewill OA. A quantitative assessment of topical antiphilogistic potencies of corticosteroids and non steroids. Medipharm Med J 1987; 1: 10-13.
- Monceda S, Viane JR. Mode of action of Aspirin like drugs. Adv Intern Med 1970; 24: 1-22.
Details
| Primary Language | English |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | January 14, 2013 |
| Published in Issue | Year 2009 Volume: 14 Issue: 1 |