EDTA-Dependent platelet clumping in a patient with hypothyroidism

Year 2010, Volume: 15 Issue: 1, 31 - 33, 15.01.2013

Felipe Montes Pena Sabrina Bernardez Pereira Renato De Freitas Ribeiro Niemeyer Bruno De Freitas Ribeiro Niemeyer

Abstract

Abstract. The pseudothrombocytopenia by ethylenediaminetetraacetic acid is caused by natural antiplatelet antibodies and is responsible for thrombocytopenia when platelet count is performed by automatic devices. Although it is difficult to assess the rate of this phenomenon, it is believed that the incidence is higher in hospitalized patients, especially in those with liver and autoimmune diseases and cancer. In this article we describe a female patient with complaints of clinical hypothyroidism and repeated values of thrombocytopenia, which was diagnosed as pseudothrombocytopenia due to ethylenediaminetetraacetic acid after proper analysis.

 

Key words: Pseudothrombocytopenia; antibodies, platelet count, hypothyroidism

Keywords

Pseudothrombocytopenia, antibodies, platelet count, hypothyroidism

References

• Pegels JG, Bruynes EC, Engelfriet CP, von dem Borne AE. Pseudothrombocytopenia: an immunologic study on platelet antibodies dependent on ethylene diamine tetra-acetate. Blood 1982; 59: 157-161.
• von dem Borne AE, van der Lelie J, Vos JJE, et al. Antibodies against cryptantigens of platelets. Characterization and significance for the serologist. Curr Stud Hematol Blood Transfus 1986; 52: 33-46.
• Dalamangas LC, Slaughter TF. Ethylenediaminetetraacetic acid-dependent pseudothrombocytopenia in a cardiac surgical patient. Anesth Analg 1998; 86: 1210-1211.
• Vicart A, Banfi G, Bonini PA. EDTA-dependent pseudothrombocytopaenia: a 12-month epidemiological study. Scand J Clin Lab Invest 1988; 48: 537-542
• Rosse WF. 1990. Autoimmune hemolytic anemia due to cold-reacting antibodies:cold agglutinin disease. In: Clinical Immunohematology: Basic Concepts and Clinical Applications. W. F. Rosse (eds). Blackwell Scientific Publications, Boston: pp 555-582.
• Spiess BD. Coagulation monitoring in the perioperative period. Int Anesthesiol Clin 2004; 42: 55-71.
• Puyo CA. Thrombocytopenia. Int Anesthesiol Clin 2001; 39: 17-34.
• Andres E, Dali-Youcef N, Serraj K , Zimmer J. Recognition and management of drug-induced cytopenias: the example of idiosyncratic druginduced thrombocytopenia. Expert Opin Drug Saf 2009; 8: 183-190.
• García Suárez J, Merino JL, Rodríguez M, Velasco A, Moreno MC. Pseudothrombocytopenia: incidence, causes and methods of detection. Sangre (Barc) 1991; 36: 197-200 (in Spanish).
• Sakurai S, Shiojima I, Takeshi T, Tanigawa T, Nakahara K. Aminoglycosides prevent and dissociate the aggregation of platelets in patients with EDTA-dependent pseudothrombocytopenia. Br J Haematol 1997; 99: 817-823.