Abstract
References
- 1. Jacobson RM. An update on childhood and adolescent vaccines. Mayo Clin Proc 2009; 84: 457-459.
- 2. Centers for Disease Control and Prevention. Diphtheria-Tetanus-Pertussis Vaccine Information Statement. http://www.immunize.org/VIS/dtap01.pdf.
- 3. Manley J, Taddio A. Acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization. Ann Pharmacother 2007; 41: 1227-1232.
- 4. Ameer B, Greenblatt DJ. Acetaminophen. Ann Intern Med 1977; 87: 202-209.
- 5. Flower RJ, Moncada S, Vane JR: Analgesicantipyretic and anti-inflammatory agents:Paraaminophenol derivatives, in Gilman AG, Goodman LS, Rail TW, et al (eds): The Pharmacological Basis of Therapeutics. New York, Macmillan Publishing Co Inc, 1985, pp 692-695.
- 6. Prymula R, Siegrist CA, Chlibek R, et al. Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials. Lancet 2009; 374: 1339-1350.
- 7. Yalçin SS. Prophylactic paracetamol at the time of infant vaccination reduces the risk of fever, but also reduces antibody response. Evid Based Nurs. 2010 Jun 8.
The effect of prophylactic paracetamol administration on adverse reactions following DTP vaccination
Abstract
Abstract. Immunization is one of the great accomplishments of the field of public health. Various side effects in the form of local reactions and systemic symptoms occur frequently after diphtheria, tetanus toxoids and pertussis (DTP) vaccination. The present study was undertaken to measure the effect of prophylactic paracetamol on reactions during the first 24 hours of DTP vaccination in a double blinded controlled manner, including 300 children. The adverse reactions were overall higher in placebo group compared to the prophylactic paracetamol group. In all the four age groups significant differences were noted for fever. Significant differences were also noted for fussiness in all the age groups thus concluding that there is an overall beneficial effect of prophylactic paracetamol in reducing the adverse effects following DTP vaccination.
Key words: prophylactic paracetamol, DTP vaccination, adverse reactions
References
- 1. Jacobson RM. An update on childhood and adolescent vaccines. Mayo Clin Proc 2009; 84: 457-459.
- 2. Centers for Disease Control and Prevention. Diphtheria-Tetanus-Pertussis Vaccine Information Statement. http://www.immunize.org/VIS/dtap01.pdf.
- 3. Manley J, Taddio A. Acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization. Ann Pharmacother 2007; 41: 1227-1232.
- 4. Ameer B, Greenblatt DJ. Acetaminophen. Ann Intern Med 1977; 87: 202-209.
- 5. Flower RJ, Moncada S, Vane JR: Analgesicantipyretic and anti-inflammatory agents:Paraaminophenol derivatives, in Gilman AG, Goodman LS, Rail TW, et al (eds): The Pharmacological Basis of Therapeutics. New York, Macmillan Publishing Co Inc, 1985, pp 692-695.
- 6. Prymula R, Siegrist CA, Chlibek R, et al. Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials. Lancet 2009; 374: 1339-1350.
- 7. Yalçin SS. Prophylactic paracetamol at the time of infant vaccination reduces the risk of fever, but also reduces antibody response. Evid Based Nurs. 2010 Jun 8.
Details
| Primary Language | English |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | January 22, 2013 |
| Published in Issue | Year 2011 Volume: 16 Issue: 4 |