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The Effect of Dorzolamide on Intraocular Pressure and Ocular Pulse Amplitude: Adjunctive Therapy to Beta-Blockers as a Substitite for Pilocarpine or as aSecond-Line Therapeutic Agent in Patients withOpen-Angle Glaucoma

Year 2002, Volume: 7 Issue: 1, 1 - 5, 26.02.2013

Abstract

Objective:To evaluate the effect of dorzolamide on the
intraocular pressure (IOP), ocular pulse amplitude
(OPA), systemic blood pressure and pulse rate in open-angle glaucoma patients using a beta-blocker and 2%
pilocarpine combination and beta-blocker
monotherapy. The secondary aim was to find out the
effect of dorzolamide on IOP and OPA in patients using
selective versus nonselective beta-blocker.
Methods:Thirteen patients who had beta-blocker and
pilocarpine combination (Group 1) and 15 patients who
had beta-blocker monotherapy (Group 2) were
enrollled. A randomly selected eye of bilaterally
affected patients was included in the observer-blinded
and parallel-group study. Baseline data consisted of 4
day-time IOP, OPA, systemic blood pressure and pulse
rate measurements. Patients in Group 1 discontinued
pilocarpine and used beta-blocker-dorzolamide
combination and patients in Group 2 used dorzolamide
as a second-line therapeutic agent with a beta-blocker.
The same measurements were performed after 4 weeks
and after 6 months in both groups.
Results:  In Group 1 the baseline IOP was 18.9±2.2
mmHg; after 4 weeks and 6 months no statistically
significant change was observed (17.6±2.3 and 17.8±3.2
mmHg respectively, p>0.05). However in Group 2, a
statistically significant IOP decrease from 22.5 ± 3.3
mmHg to 18.0 ± 2.0 mmHg after 4 weeks (p<0.05) and
to 18.4 ± 1.8 mmHg after 6 months (p<0.05) occurred.
There were no changes in OPA, systemic blood
pressure and pulse rate in either  groups during the
follow-up period. The additive effect of dorzolamide
with selective and nonselective beta-blockers was
analyzed using a cross-sectional study design of the
data obtained from 28 eyes. Twelve patients who used
selective beta-blocker and dorzolamide showed an
increase in IOP (from 18.4±2.3 to 19.3±1.9 mmHg,
p>0.05) and a decrease in OPA (from 3.7±1.2 to 3.2±0.9
mmHg, p>0.05) after 5 months, although these changes
were not statistically significant. The IOP was stable
during the same period (17.3±2.0 and 17.2±2.6 mmHg,
p>0.05) but the OPA showed a slight, but not significant
increase (2.7±1.1 and 3.1± 1.5 mmHg, p>0.05) in sixteen
patients using nonselective beta-blocker and
dorzolamide.
Conclusion:  Dorzolamide is safe and effective when
used with beta-blockers but its interaction with
selective and nonselective beta-blockers needs further
investigation.

Key Words: Intraocular pressure, ocular pulse amplitude,
medical therapy, beta-blocker, dorzolamide, pilocarpine

Year 2002, Volume: 7 Issue: 1, 1 - 5, 26.02.2013

Abstract

There are 0 citations in total.

Details

Primary Language English
Journal Section Articles
Authors

M.l. Alimgil This is me

Ö. Benian This is me

Publication Date February 26, 2013
Published in Issue Year 2002 Volume: 7 Issue: 1

Cite

APA Alimgil, M., & Benian, Ö. (2013). The Effect of Dorzolamide on Intraocular Pressure and Ocular Pulse Amplitude: Adjunctive Therapy to Beta-Blockers as a Substitite for Pilocarpine or as aSecond-Line Therapeutic Agent in Patients withOpen-Angle Glaucoma. EASTERN JOURNAL OF MEDICINE, 7(1), 1-5.
AMA Alimgil M, Benian Ö. The Effect of Dorzolamide on Intraocular Pressure and Ocular Pulse Amplitude: Adjunctive Therapy to Beta-Blockers as a Substitite for Pilocarpine or as aSecond-Line Therapeutic Agent in Patients withOpen-Angle Glaucoma. EASTERN JOURNAL OF MEDICINE. March 2013;7(1):1-5.
Chicago Alimgil, M.l., and Ö. Benian. “The Effect of Dorzolamide on Intraocular Pressure and Ocular Pulse Amplitude: Adjunctive Therapy to Beta-Blockers As a Substitite for Pilocarpine or As ASecond-Line Therapeutic Agent in Patients WithOpen-Angle Glaucoma”. EASTERN JOURNAL OF MEDICINE 7, no. 1 (March 2013): 1-5.
EndNote Alimgil M, Benian Ö (March 1, 2013) The Effect of Dorzolamide on Intraocular Pressure and Ocular Pulse Amplitude: Adjunctive Therapy to Beta-Blockers as a Substitite for Pilocarpine or as aSecond-Line Therapeutic Agent in Patients withOpen-Angle Glaucoma. EASTERN JOURNAL OF MEDICINE 7 1 1–5.
IEEE M. Alimgil and Ö. Benian, “The Effect of Dorzolamide on Intraocular Pressure and Ocular Pulse Amplitude: Adjunctive Therapy to Beta-Blockers as a Substitite for Pilocarpine or as aSecond-Line Therapeutic Agent in Patients withOpen-Angle Glaucoma”, EASTERN JOURNAL OF MEDICINE, vol. 7, no. 1, pp. 1–5, 2013.
ISNAD Alimgil, M.l. - Benian, Ö. “The Effect of Dorzolamide on Intraocular Pressure and Ocular Pulse Amplitude: Adjunctive Therapy to Beta-Blockers As a Substitite for Pilocarpine or As ASecond-Line Therapeutic Agent in Patients WithOpen-Angle Glaucoma”. EASTERN JOURNAL OF MEDICINE 7/1 (March 2013), 1-5.
JAMA Alimgil M, Benian Ö. The Effect of Dorzolamide on Intraocular Pressure and Ocular Pulse Amplitude: Adjunctive Therapy to Beta-Blockers as a Substitite for Pilocarpine or as aSecond-Line Therapeutic Agent in Patients withOpen-Angle Glaucoma. EASTERN JOURNAL OF MEDICINE. 2013;7:1–5.
MLA Alimgil, M.l. and Ö. Benian. “The Effect of Dorzolamide on Intraocular Pressure and Ocular Pulse Amplitude: Adjunctive Therapy to Beta-Blockers As a Substitite for Pilocarpine or As ASecond-Line Therapeutic Agent in Patients WithOpen-Angle Glaucoma”. EASTERN JOURNAL OF MEDICINE, vol. 7, no. 1, 2013, pp. 1-5.
Vancouver Alimgil M, Benian Ö. The Effect of Dorzolamide on Intraocular Pressure and Ocular Pulse Amplitude: Adjunctive Therapy to Beta-Blockers as a Substitite for Pilocarpine or as aSecond-Line Therapeutic Agent in Patients withOpen-Angle Glaucoma. EASTERN JOURNAL OF MEDICINE. 2013;7(1):1-5.