Abstract
Objective: Glucose 6-phosphate dehydrogenase
(G6PD) deficiency manifests genetic polymorphism
and prevalence of its varying among geographic
regions and ethnic groups. G6PD deficiency is
important in Gaziantep, Turkey because high deficiency
prevalence was observed in Adana and Antakya, the
neighbouring Mediterranean cities.
Methods: In this study, sera from 306 subjects (166
female, 140 male) between 1-80 years old were for
erythrocyte G6PD activity with International Committee
for Standardization in Hematology (ICSH) method. After
excluding the outliers, 95 % interpercentile interval was
accepted as reference limit.
Results: In Gaziantep reference group erythrocyte
G6PD activity limits for subjects over one year old are
6.4 - 13.2 U/ g Hb, 30ºC. Seven subjects with low enzyme
activities indicate that G6PD deficiency frequency is
approximately 2.3 ± 1% in Gaziantep.
Conclusion: G6PD deficiency frequence is
approximately 2.3 ± 1 % in Gaziantep which is higher
than the mean prevalence in Turkey.
Key words: Glucose 6-phosphate dehydrogenase,
reference limits, deficiency frequency
Keywords
Details
| Primary Language | English |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | February 26, 2013 |
| Published in Issue | Year 2002 Volume: 7 Issue: 1 |