Effect of prostatectomy In patients with elevated serum prostate specific antigen levels and Lower Urinary Tract Symptoms: A Prospective Study

Year 2014, Volume: 19 Issue: 3, 141 - 145, 06.01.2015

Şenol Adanur , Hasan Aydın , Hasan Rıza Aydın , Tevfik Ziypak Erdem Koç Erdem Koç Turgut Yapanoğlu İsa Özbey , Özkan Polat

Abstract

Abstract

Objective: Our aim is  to determine the impact of prostatectomy on  serum prostate specific antıgen levels in patıents with Lower Urinary Tract symptoms(LUTS), but  negative multicore prostate biopsy results and higher serum prostate specific antigen levels

Method: A total of 100 patients referred to our clinics with lower urinary system symptoms without any evidence of suspect prostate carcinoma in digital rectal examination, and transurethral ultrasound (TRUS) but had undergone prostatic biopsy because of higher serum  prostate specific antigen (PSA) levels (PSA>4ng/ml) with resultant histopathologically benign diagnoses were retrospectively evaluated. The association between preoperative and postoperative 3 and 6 month serum PSA levels was statistically evaluated in patients who had undergone transurethral resection of the prostate (TUR-P) or open prostatectomy resection with the diagnosis of benign prostatic hyperplasia (BPH), and also correlation between changes in serum PSA levels and histopathologic diagnosis was analysed.

Results: The preoperative mean total PSA (tPSA) and free PSA (fPSA) values were 16.89 ng/mL and 3.65ng/mL, respectively. Postoperative 3 month- mean tPSA and fPSA values were 1.34 and 0.4ng/mL, while postoperative 6 month mean tPSA and fPSA values were determined as 1.59 and 0.56ng/mL, respectively. Postoperative histopathologic evaluation of the surgical specimens of the patients revealed BPH in 84%, BPH + prostatitis in 12%, and prostate cancer 4% of the cases, respectively.

Conclusion: BPH surgery can be performed safely on patients with symptomatic BPH and increased PSA levels without any evidence of prostate carcinoma. Favourable and comforting results can be achieved with BPH surgery, which improves symptoms and normalises PSA values.

 

Key words: Prostate specific antigen, Benign Prostatic Hyperplasia, Prostatectomy

Keywords

Prostate specific antigen, benign prostatic hyperplasia, prostatectomy

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