Echium italicum Plant Extracts Have Wound Healing Potential in Human Dermal Fibroblast (HDF) Cell

Year 2024, , 14 - 21, 25.02.2025

Derya Akduman , Rahmiye Akduman , Merve Şimşek Geyik , Mesut Akyüz

https://doi.org/10.5281/zenodo.14932872

Abstract

Plants have an important place in the development of drugs used in the treatment of diseases, as in many areas. The flower and
leaf parts of the Echium italicum plant used in the study have been used in many studies, but no information has been found
in the literature about the use of the root part in increasing cell viability and wound healing treatment. In this study, the effects
of Echium italicum , one of the Echium species naturally growing in our country, on cell viability and wound healing were
investigated in vitro. Extracts prepared with different polarity solvents from the root and aerial parts of the plant were applied
to the human dermal fibroblast (HDF) cell line to evaluate their effect on cell viability and wound healing potential. Cell viability
was determined with the CVDK-8 method, and the wound healing activity of the plant was determined with the scratch assay.
In summary, the effects of the Echium italicum root extract on wound healing were examined, and the medicinal properties of
the plant suggested in traditional medicine were scientifically evaluated.

Keywords

Echium italicum, cell viability, wound healing, HDF cell

Supporting Institution

Tübitak

Project Number

1919B012307029

Thanks

This study was supported by Tubitak 2209 project.

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