İmin Fonksiyonu İçeren Bazı Benzimidazol Türevlerinin Mikrodalga Destekli Sentezi

Öz

Benzimidazol modern ilaç keşfinde önemli bir farmakofordur. Birçok benzimidazole türevi yeni ilaç adayı bileşikler elde etmek amacıyla organik kimyacılar tarafından sentezlenmektedir. Bu çalışmada, imin fonksiyonu içeren yedi yeni benzimidazol türevi bileşik mikrodalga ışıma ve geleneksel yöntemle sentezlenmiştir. Elde edilen sonuçlara göre mikrodalga ısıtmanın geleneksel ısıtmaya göre verim, üründeki saflık ve zaman yönünde avantajları olduğu görülmüştür.

Anahtar Kelimeler

• Benzimidazol
• Schiff bazı
• Mikrodalga Işıma
• İmin fonksiyonu

Microwave-Assisted Synthesis of Some Benzimidazole Derivatives Containing Imine Function

Abstract

Benzimidazole is an important pharmacophore in modern drug discovery. Many benzimidazole derivatives have been synthesized by organic chemist to obtain new drug candidates. In this work, seven new benzimidazole derivatives containing imine function have been synthesized by using microwave irradiation and conventional heating procedure. The results showed that microwave heating has many advantages on classical heating procedure on yields, purity of product and reduced times.

Keywords

• Benzimidazole
• Schiff base
• Microwave irradiation
• Imine function

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