Synthesis and Antimicrobial Activity Studies of Cyclobutane Ring Containing Schiff Base and their Metal Complexes

Abstract

In this study, thiosemicarbazone derivative Schiff base containing cyclobutane group and their Cu(II), Ni(II) ve Zn(II) complexes were synthesised and characterized. Purification of the synthesised compounds were carried out with crystallography and column cromatography techniques. In the characterization of the Schiff base and their complexes, IR, ¹H NMR, ¹³ C NMR spectral techniques and elemental analysis were used. All the complexes were found to be mononuclear and ML₂ form. Besides, antimicrobial activities of the Schiff base and its transition metal complexes have been tested different microorganisms.

Keywords

• Schiff Bases,Cyclobutane,Metal Complexes,Antimicrobial Activty

Siklobütan Halkası İçeren Schiff Bazı ve Metal Komplekslerinin Sentezi ve Antimikrobiyal Aktivite Çalışmaları

Abstract

Bu çalışmada yapısında siklobütan grubu bulunan tiyosemikarbazon türevi Schiff bazı ve bunun nikel, bakır ve çinko kompleksleri sentezlenmiştir. Sentezlenen bileşiklerin saflaştırılması kristallendirme ve kolon kromatografisi ile yapılmıştır. Karakterizasyon işlemlerinde ise IR, ¹H NMR, ¹³C NMR ve elementel analiz gibi enstrümental analiz yöntemleri kullanılmıştır. Sentezlenen komplekslerin mononükleer olduğu ve ML₂ yapısında olduğu bulunmuştur. Ayrıca, sentezlenen bileşiklerin farklı mikroorganizmalara karşı antimikrobiyal etkileri araştırılmıştır.

Keywords

• Schiff Bazı,Siklobütan,Metal Kompleksleri,Antimikrobiyal Aktivite

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