Obezite ve Mikrobiyota Etkileşimlerine Genel Bakış

Year 2021, , 275 - 291, 31.12.2021

Jale Çatak , Esra Yıldırım , Nureslem Memiş

https://doi.org/10.31590/ejosat.935513

Cited By: 3

Abstract

Bağırsak mikrobiyotası, konakçıyla simbiyotik bir ilişki içindedir ve birçok fizyolojik olaya aracılık etmektedir. Bağırsak florasının dengesizliği olarak adlandırılan disbiyoz, obeziteyle ilişkilendirilmektedir. Disbiyoz, bağırsak geçirgenliğinin artmasına neden olmaktadır, böylece sistemik dolaşımda lipopolisakkarit seviyeleri yükselmekte ve inflamasyon gelişmektedir. Bağırsak mikrobiyotasının bir diğer rolü ise diyetten enerji ekstraksiyonunu ve endokannabinoid sistemi modüle etmesidir. Bununla birlikte bağışıklıkla etkileşim halindedir. Obezitede görülen inflamasyon, artmış endokannabinoid sistem aktivitesi, bağırsak ve bağışıklık değişiklikleri; bağırsak mikrobiyotasını umut verici bir terapötik hedef yapmaktadır. Bağırsak mikrobiyotasının, probiyotik, prebiyotik, egzersiz ve fonksiyonel besinler gibi bileşenlerle modülasyonunun, obezite ve obeziteyle ilişkili bozuklukları iyileştirmede güçlü bir yaklaşım olabileceği düşünülmektedir.

Keywords

Mikrobiyota, Obezite, Bağışılık, Beslenme, Probiyotik, Prebiyotik

Overview of Obesity and Microbiota Interactions

Abstract

The gut microbiota has a symbiotic relationship with its host and can help many physiological events. Dysbiosis, called imbalance of the gut microbial population, is associated with obesity. Dysbiosis causes increased intestinal permeability, so in the systemic circulation, lipopolysaccharide levels rise, and inflammation develops. Another role of the gut microbiota is that it modulates energy extraction from the diet and the endocannabinoid system. However, it interacts with immunity. Inflammation, increased endocannabinoid system activity, and intestinal and immune changes in obesity make the gut microbiota a promising treatment target in obesity. It is thought that modulation of the gut microbiota with components such as probiotics, prebiotics, exercise, and functional foods may be a powerful approach to improving obesity and obesity-related disorders.

Keywords

Microbiota, Obesity, Immunity, Nutrition, Probiotic, Prebiotic

References

• Allen, J. M., Mailing, L. J., Niemiro, G. M., Moore, R., Cook, M. D., White, B. A., et al. (2018). Exercise alters gut microbiota composition and function in lean and obese humans. Med Sci Sports Exerc, 50(4), 747-57.
• Araújo, J. R., Tomas, J., Brenner, C., & Sansonetti, P. J. (2017). Impact of high-fat diet on the intestinal microbiota and small intestinal physiology before and after the onset of obesity. Biochimie, 141, 97-106.
• Avsar, O., Kuskucu, A., Sancak, S., Genc, E. (2017). Are dopaminergic genotypes risk factors for eating behavior and obesity in adults? Neurosci Lett. 27(654), 28-32. DOI: 10.1016/j.neulet.2017.06.023.
• Bakker, G. J., & Nieuwdorp, M. (2017). Relationship between gut microbiota, energy metabolism, and obesity. In The Microbiota in Gastrointestinal Pathophysiology (pp. 255-258). Academic Press.
• Ballini, A., Scacco, S., Boccellino, M., Santacroce, L., & Arrigoni, R. (2020). Microbiota and Obesity: Where Are We Now?. Biology, 9(12), 415.
• Bellenger, J., Bellenger, S., Bourragat, A., Escoula, Q., Weill, P., & Narce, M. (2021). Intestinal microbiota mediates the beneficial effects of n-3 polyunsaturated fatty acids during dietary obesity. OCL, 28, 21.
• Biyong, E. F., Alfos, S., Dumetz, F., Helbling, J. C., Aubert, A., Brossaud, J., et al. (2021). Dietary vitamin A supplementation prevents early obesogenic diet-induced microbiota, neuronal and cognitive alterations. International Journal of Obesity, 45(3), 588-598.
• Blaner, W. S. (2019). Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders. Pharmacology & therapeutics, 197, 153-178.
• Bruce-Keller, A. J., Salbaum, J. M., Luo, M., Blanchard IV, E., Taylor, C. M., Welsh, D. A., & Berthoud, H. R. (2015). Obese-type gut microbiota induce neurobehavioral changes in the absence of obesity. Biological psychiatry, 77(7), 607-615.
• Cao, S. Y., Zhao, C. N., Xu, X. Y., Tang, G. Y., Corke, H., Gan, R. Y., & Li, H. B. (2019). Dietary plants, gut microbiota, and obesity: Effects and mechanisms. Trends in Food Science & Technology, 92, 194-204.
• Clarke, S. F., Murphy, E. F., O'Sullivan, O., Lucey, A. J., Humphreys, M., Hogan, A., ... & Cotter, P. D. (2014). Exercise and associated dietary extremes impact on gut microbial diversity. Gut, 63(12), 1913-1920.
• Coelho, O. G. L., Cândido, F. G., & Alfenas, R. D. C. G. (2019). Dietary fat and gut microbiota: mechanisms involved in obesity control. Critical reviews in food science and nutrition, 59(19), 3045-3053.
• Crovesy, L., Masterson, D., & Rosado, E. L. (2020). Profile of the gut microbiota of adults with obesity: a systematic review. European journal of clinical nutrition, 74(9), 1251-1262.
• Çatak, J., Develi, A. Ç., Sorguven, E., Özilgen, M., & İnal, H. S. (2015). Lifespan entropy generated by the masseter muscles during chewing: an indicator of the life expectancy?. International Journal of Exergy, 18(1), 46-67.
• Çatak, J., Develi, E., & Bayram, S. (2019). Comparison the work of breathing between healthy and obese by thermodynamic analysis. European Respiratory Journal; 54(63), PA753.; DOI: 10.1183/13993003.congress-2019.PA753.
• Çatak, J., Develi, E., & Bayram, S. (2021). How does obesity affect bioenergetics in human respiratory muscles? Human Nutrition & Metabolism, 26, 200136 DOI: 10.1016/j.hnm.2021.200136.
• de Souza, A. Z. Z., Zambom, A. Z., Abboud, K. Y., Reis, S. K., Tannihão, F., Guadagnini, D.,et al (2015). Oral supplementation with L-glutamine alters gut microbiota of obese and overweight adults: A pilot study. Nutrition, 31(6), 884-889.
• Dong, J. L., Zhu, Y. Y., Ma, Y. L., Xiang, Q. S., Shen, R. L., & Liu, Y. Q. (2016). Oat products modulate the gut microbiota and produce anti-obesity effects in obese rats. Journal of Functional Foods, 25, 408-420.
• Ejtahed, H. S., Soroush, A. R., Siadat, S. D., Hoseini-Tavassol, Z., Larijani, B., & Hasani-Ranjbar, S. (2019). Targeting obesity management through gut microbiota modulation by herbal products: A systematic review. Complementary therapies in medicine, 42, 184-204.
• Everard, A., & Cani, P. D. (2013). Diabetes, obesity and gut microbiota. Best practice & research Clinical gastroenterology, 27(1), 73-83.
• Faintuch, J., & Faintuch, S. (Eds.). (2019). Microbiome and Metabolome in Diagnosis, Therapy, and Other Strategic Applications. Academic Press.
• Fan, Y., & Pedersen, O. (2020). Gut microbiota in human metabolic health and disease. Nature Reviews Microbiology, 1-17.
• Fischer, M., Sipe, B., Torbeck, M., Xu, H., Kassam, Z., & Allegretti, J. R. (2017). Does fecal microbiota transplantation from an obese donor lead to weight gain? a case series of 70 recipients. Gastroenterology, 152(5), S1004.
• Fitzpatrick, E., & Dhawan, A. (2019). Childhood and adolescent nonalcoholic fatty liver disease: is it different from adults?. Journal of Clinical and Experimental Hepatology, 9(6), 716-722.
• Gizlici, M. N., & Çatak, J. (2019). Diabetes Mellitus ve Çinko İlişkisi. Türkiye Diyabet ve Obezite Dergisi, 3(2), 107-113.
• Gumpper, K., Dangel, A. W., Pita-Grisanti, V., Krishna, S. G., Lara, L. F., Mace, T., et al. (2020). Lipocalin-2 expression and function in pancreatic diseases. Pancreatology, 20(3), 419-424.
• Hiel, S., Gianfrancesco, M. A., Rodriguez, J., Portheault, D., Leyrolle, Q., Bindels, L. B., et al. (2020). Link between gut microbiota and health outcomes in inulin-treated obese patients: lessons from the Food4Gut multicenter randomized placebo-controlled trial. Clinical Nutrition, 39(12), 3618-3628.
• Hu, S., Yang, H., Gao, X., Li, S., Jiang, W., & Liu, Y. (2020). Egg oil from Portunus trituberculatus alleviated obesity and regulated gut microbiota in mice. Scientific Reports, 10(1), 1-10.
• Kim, D. H., Kim, H., Jeong, D., Kang, I. B., Chon, J. W., Kim, H. S., et al. (2017). Kefir alleviates obesity and hepatic steatosis in high-fat diet-fed mice by modulation of gut microbiota and mycobiota: targeted and untargeted community analysis with correlation of biomarkers. The Journal of nutritional biochemistry, 44, 35-43.
• Klancic, T., & Reimer, R. A. (2020). Gut microbiota and obesity: Impact of antibiotics and prebiotics and potential for musculoskeletal health. Journal of Sport and Health Science, 9(2), 110-118.
• Lane, M., Howland, G., West, M., Hockey, M., Marx, W., Loughman, A., et al. (2020). The effect of ultra-processed very low-energy diets on gut microbiota and metabolic outcomes in individuals with obesity: A systematic literature review. Obesity research & clinical practice.
• Legrand, R., Lucas, N., Dominique, M., Azhar, S., Deroissart, C., Le Solliec, M. A., et al. (2020). Commensal Hafnia alvei strain reduces food intake and fat mass in obese mice—A new potential probiotic for appetite and body weight management. International Journal of Obesity, 44(5), 1041-1051.
• Li, G., Xie, C., Lu, S., Nichols, R. G., Tian, Y., Li, L., et al. (2017). Intermittent fasting promotes white adipose browning and decreases obesity by shaping the gut microbiota. Cell metabolism, 26(4), 672-685.
• Lin, H., An, Y., Hao, F., Wang, Y., & Tang, H. (2016). Correlations of fecal metabonomic and microbiomic changes induced by high-fat diet in the pre-obesity state. Scientific reports, 6(1), 1-14.
• Liu, R., Hong, J., Xu, X., Feng, Q., Zhang, D., Gu, Y., et al. (2017). Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nature medicine, 23(7), 859.
• Luck, H., Khan, S., Kim, J. H., Copeland, J. K., Revelo, X. S., Tsai, S., et al. (2019). Gut-associated IgA+ immune cells regulate obesity-related insulin resistance. Nature communications, 10(1), 1-17.
• Luthold, R. V., Fernandes, G. R., Franco-de-Moraes, A. C., Folchetti, L. G., & Ferreira, S. R. G. (2017). Gut microbiota interactions with the immunomodulatory role of vitamin D in normal individuals. Metabolism, 69, 76-86.
• Ly, N. P., Litonjua, A., Gold, D. R., & Celedón, J. C. (2011). Gut microbiota, probiotics, and vitamin D: interrelated exposures influencing allergy, asthma, and obesity?. Journal of Allergy and Clinical Immunology, 127(5), 1087-1094.
• Mabey, J. G., Chaston, J. M., Castro, D. G., Adams, T. D., Hunt, S. C., & Davidson, L. E. (2020). Gut microbiota differs a decade after bariatric surgery relative to a nonsurgical comparison group. Surgery for Obesity and Related Diseases, 16(9), 1304-1311.
• Mishra, A. K., Dubey, V., & Ghosh, A. R. (2016). Obesity: an overview of possible role (s) of gut hormones, lipid sensing and gut microbiota. Metabolism, 65(1), 48-65.
• Miyamoto, J., Igarashi, M., Watanabe, K., Karaki, S. I., Mukouyama, H., Kishino, S., et al. (2019). Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids. Nature communications, 10(1), 1-15.
• Mojsak, P., Rey-Stolle, F., Parfieniuk, E., Kretowski, A., & Ciborowski, M. (2020). The role of gut microbiota (GM) and GM-related metabolites in diabetes and obesity. A review of analytical methods used to measure GM-related metabolites in fecal samples with a focus on metabolites’ derivatization step. Journal of Pharmaceutical and Biomedical Analysis, 113617.
• Monda, V., Villano, I., Messina, A., Valenzano, A., Esposito, T., Moscatelli, F., ... & Messina, G. (2017). Exercise modifies the gut microbiota with positive health effects. Oxidative medicine and cellular longevity, 2017, 1-8.
• Moran, C. P., & Shanahan, F. (2014). Gut microbiota and obesity: role in aetiology and potential therapeutic target. Best practice & research Clinical gastroenterology, 28(4), 585-597.
• Moschen, A. R., Adolph, T. E., Gerner, R. R., Wieser, V., & Tilg, H. (2017). Lipocalin-2: a master mediator of intestinal and metabolic inflammation. Trends in Endocrinology & Metabolism, 28(5), 388-397.
• Muscogiuri, G., Cantone, E., Cassarano, S., Tuccinardi, D., Barrea, L., Savastano, S., & Colao, A. (2019). Gut microbiota: a new path to treat obesity. International journal of obesity supplements, 9(1), 10-19.
• Nagano, T., & Yano, H. (2020). Dietary cellulose nanofiber modulates obesity and gut microbiota in high-fat-fed mice. Bioactive Carbohydrates and Dietary Fibre, 22, 100214.
• Nakamura, A., Yokoyama, Y., Tanaka, K., Benegiamo, G., Hirayama, A., Zhu, Q., et al. (2020). Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling. Iscience, 23(9), 101522.
• Neyrinck, A. M., Rodriguez, J., Zhang, Z., Seethaler, B., Sánchez, C. R., Roumain, M., et al. (2020). Fecal metabolites reflecting the interaction between prebiotic dietary fiber and the gut microbiota in obese patients. Clinical Nutrition ESPEN, 40, 521-522.
• Nicolucci, A. C., Hume, M. P., Martínez, I., Mayengbam, S., Walter, J., & Reimer, R. A. (2017). Prebiotics reduce body fat and alter intestinal microbiota in children who are overweight or with obesity. Gastroenterology, 153(3), 711-722.
• Núñez, I. N., Galdeano, C. M., de LeBlanc, A. D. M., & Perdigón, G. (2014). Evaluation of immune response, microbiota, and blood markers after probiotic bacteria administration in obese mice induced by a high-fat diet. Nutrition, 30(11-12), 1423-1432.
• Palmas, V., Pisanu, S., Madau, V., Casula, E., Deledda, A., Cusano, R., et al. (2021). Gut microbiota markers associated with obesity and overweight in Italian adults. Scientific reports, 11(1), 1-14.
• Parks, B. W., Nam, E., Org, E., Kostem, E., Norheim, F., Hui, S. T., et al. (2013). Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell metabolism, 17(1), 141-152.
• Pascale, A., Marchesi, N., Govoni, S., Coppola, A., & Gazzaruso, C. (2019). The role of gut microbiota in obesity, diabetes mellitus, and effect of metformin: new insights into old diseases. Current opinion in pharmacology, 49, 1-5.
• Petriz, B. A., Castro, A. P., Almeida, J. A., Gomes, C. P., Fernandes, G. R., Kruger, R. H., et al. (2014). Exercise induction of gut microbiota modifications in obese, non-obese and hypertensive rats. BMC genomics, 15(1), 1-13.
• Qiu, X., Macchietto, M. G., Liu, X., Lu, Y., Ma, Y., Guo, H., et al. (2020). Identification of gut microbiota and microbial metabolites regulated by an antimicrobial peptide lipocalin 2 in high fat diet-induced obesity. International Journal of Obesity, 45(1), 143-154.
• Quiroga, R., Nistal, E., Estébanez, B., Porras, D., Juárez-Fernández, M., Martínez-Flórez, S., et al. (2020). Exercise training modulates the gut microbiota profile and impairs inflammatory signaling pathways in obese children. Experimental & Molecular Medicine, 52(7), 1048-1061.
• Rabot, S., Membrez, M., Blancher, F., Berger, B., Moine, D., Krause, L., et al. (2016). High fat diet drives obesity regardless the composition of gut microbiota in mice. Scientific reports, 6(1), 1-11.
• Reijnders, D., Goossens, G. H., Hermes, G. D., Neis, E. P., van der Beek, C. M., Most, J., et al. (2016). Effects of gut microbiota manipulation by antibiotics on host metabolism in obese humans: a randomized double-blind placebo-controlled trial. Cell metabolism, 24(1), 63-74.
• Rodriguez, J., Neyrinck, A., Le Roy, T., Leclercq, S., Hiel, S., Cani, P., et al. (2018). Implication of the gut microbiota in personalized metabolic response to dietary inulin in obese patients. Clinical Nutrition, 37, S148.
• Rosenbaum, M., Knight, R., & Leibel, R. L. (2015). The gut microbiota in human energy homeostasis and obesity. Trends in Endocrinology & Metabolism, 26(9), 493-501.
• Sanchez-Carrillo, S., Ciordia, S., Rojo, D., Zubeldia-Varela, E., Méndez-García, C., Martínez-Martínez, M., et al. (2021). A body weight loss-and health-promoting gut microbiota is established after bariatric surgery in individuals with severe obesity. Journal of Pharmaceutical and Biomedical Analysis, 193, 113747.
• Schroeder, B. O., & Bäckhed, F. (2016). Signals from the gut microbiota to distant organs in physiology and disease. Nature medicine, 22(10), 1079.
• Sen, T., Cawthon, C. R., Ihde, B. T., Hajnal, A., DiLorenzo, P. M., Claire, B., & Czaja, K. (2017). Diet-driven microbiota dysbiosis is associated with vagal remodeling and obesity. Physiology & behavior, 173, 305-317.
• Sergeev, I. N., Aljutaily, T., Walton, G., & Huarte, E. (2020). Effects of synbiotic supplement on human gut microbiota, body composition and weight loss in obesity. Nutrients, 12(1), 222.
• Shen, Q., & Maitin, V. (2015). Obesity-associated gut microbiota: characterization and dietary modulation. In Diet-Microbe Interactions in the Gut (pp. 149-171). Academic Press.
• Thomaz, F. S., Tomsett, K. I., Panchal, S. K., Worrall, S., & Nitert, M. D. (2020). Wasabi supplementation alters the composition of the gut microbiota of diet-induced obese rats. Journal of Functional Foods, 67, 103868.
• Torres-Fuentes, C., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2017). The microbiota–gut–brain axis in obesity. The lancet Gastroenterology & hepatology, 2(10), 747-756.
• Toubal, A., Kiaf, B., Beaudoin, L., Cagninacci, L., Rhimi, M., Fruchet, B., et al. (2020). Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity. Nature communications, 11(1), 1-20.
• Upadhyay, V., Poroyko, V., Kim, T. J., Devkota, S., Fu, S., Liu, D., et al. (2012). Lymphotoxin regulates commensal responses to enable diet-induced obesity. Nature immunology, 13(10), 947.
• Wang, P., Gao, X., Li, Y., Wang, S., Yu, J., & Wei, Y. (2020). Bacillus natto regulates gut microbiota and adipose tissue accumulation in a high-fat diet mouse model of obesity. Journal of Functional Foods, 68, 103923.
• Wang, Y., Yao, W., Li, B., Qian, S., Wei, B., Gong, S., et al. (2020). Nuciferine modulates the gut microbiota and prevents obesity in high-fat diet-fed rats. Experimental & Molecular Medicine, 1-17.
• Wei, M., Huang, F., Zhao, L., Zhang, Y., Yang, W., Wang, S., et al. (2020). A dysregulated bile acid-gut microbiota axis contributes to obesity susceptibility. EBioMedicine, 55, 102766.
• Wilkins, A. T., & Reimer, R. A. (2021). Obesity, Early Life Gut Microbiota, and Antibiotics. Microorganisms, 9(2), 413.
• Yu, E. W., Gao, L., Stastka, P., Cheney, M. C., Mahabamunuge, J., Torres Soto, M., et al. (2020). Fecal microbiota transplantation for the improvement of metabolism in obesity: the FMT-TRIM double-blind placebo-controlled pilot trial. PLoS medicine, 17(3), e1003051.
• Zhang, C., Yin, A., Li, H., Wang, R., Wu, G., Shen, J., et al. (2015). Dietary modulation of gut microbiota contributes to alleviation of both genetic and simple obesity in children. EBioMedicine, 2(8), 968-984.
• Zhang, C., Zhang, M., Pang, X., Zhao, Y., Wang, L., & Zhao, L. (2012). Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations. The ISME journal, 6(10), 1848-1857.
• Zhao, L. (2013). The gut microbiota and obesity: from correlation to causality. Nature Reviews Microbiology, 11(9), 639-647.
• Zmora, N., Suez, J., & Elinav, E. (2019). You are what you eat: diet, health and the gut microbiota. Nature reviews Gastroenterology & hepatology, 16(1), 35-56.
• Çatak, J. (2020). Quantitative Analyses of Glyoxal and Methylglyoxal Compounds in FrenchFry Samples by HPLC Using 4-Nitro-1, 2-Phenlenediamine as A Derivatizing Reagent. International Journal of Innovative Research and Reviews, 4(1), 20-24.
• Çatak, J., Develi, E., & Bayram, S. (2021a). How does obesity affect bioenergetics in human respiratory muscles? Human Nutrition & Metabolism, 26, 200136 DOI: 10.1016/j.hnm.2021.200136.
• Çatak, J., Demirci, A. & Yaman, M. "Besin Alerjileri ve Mikrobiyota." Avrupa Bilim ve Teknoloji Dergisi 27 (2021b): 902-910.
• Monda, V., Villano, I., Messina, A., Valenzano, A., Esposito, T., Moscatelli, F., ... & Messina, G. (2017). Exercise modifies the gut microbiota with positive health effects. Oxidative medicine and cellular longevity, 2017, 1-8.
• Avsar, O., Kuskucu, A., Sancak, S., Genc, E. (2017). Are dopaminergic genotypes risk factors for eating behavior and obesity in adults? Neurosci Lett. 27(654), 28-32. DOI: 10.1016/j.neulet.2017.06.023.
• Torres-Fuentes, C., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2017). The microbiota–gut–brain axis in obesity. The lancet Gastroenterology & hepatology, 2(10), 747-756.