Year 2020, Volume , Issue 19, Pages 746 - 756 2020-08-31

Vitamin C, vücuttaki çeşitli biyokimyasal ve fizyolojik süreçler için gerekli olan esansiyel bir mikrobesin ögesidir. Birçok meyve ve sebzede bulunan vitamin C, insan vücudunda sentezlenemediğinden dışarıdan diyetle alınması gerekmektedir. İndirgenmiş form olan L-askorbik asit ve yükseltgenmiş form olan L-dehidroaskorbik asit (DHA)’in, her ikisi de vitamin C aktivitesini korumaktadır. Askorbik asit, sodyum bağımlı vitamin C taşıyıcıları (SVCT'ler) aracılığıyla hücreye taşınırken, DHA glikoz taşıyıcı ailesi (GLUT'lar) yoluyla taşınır. Vitamin C’nin oral alımından sonra plazmadaki konsantrasyonu, hücreye ve hücre içi organellere girmek için gerekli olan taşıyıcılar tarafından sıkı bir şekilde kontrol edilmektedir. Vitamin C, triptofanın nörotransmitter olan serotonine dönüşümü, folik asit aktivasyonu ve kolesterolün safra asitlerine dönüşümü gibi bir dizi metabolik fonksiyonda önemli bir rol oynamaktadır. Biyosentetik ve gen düzenleyici enzim ailesinin bir kofaktörü olmasının yanı sıra güçlü antioksidan aktivitesi sayesinde vücudun serbest radikal hasarını azaltarak çoğu hastalığa karşı da koruyucu etki göstermektedir. Son yıllarda yapılan araştırmalar, birçok kronik hastalık üzerine vitamin C’nin olası yeni terapötik etkilerine odaklanmıştır. Bu derlemede yeterli miktarda vitamin C alımının normal vücut fonksiyonlarının sürdürülmesine, bazı hastalıklarda tedaviye yardımcı olmasına ve eksikliğinin çeşitli hastalık risklerini artırmasına yönelik etki mekanizmalarına değinilmiştir.
Vitamin C, Askorbik Asit, Dehidroaskorbik Asit, Antioksidan, Beslenme, Hastalık, Etki Mekanizması
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Primary Language tr
Subjects Engineering
Journal Section Articles
Authors

Orcid: 0000-0002-2932-4215
Author: Halime UĞUR (Primary Author)
Institution: İSTANBUL SABAHATTİN ZAİM ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0002-6731-371X
Author: Sümeyye EKER
Institution: İSTANBUL MEDİPOL ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0002-2718-0967
Author: Jale ÇATAK
Institution: İSTANBUL SABAHATTİN ZAİM ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0001-9692-0204
Author: Mustafa YAMAN
Institution: İSTANBUL SABAHATTİN ZAİM ÜNİVERSİTESİ
Country: Turkey


Dates

Publication Date : August 31, 2020

APA Uğur, H , Eker, S , Çatak, J , Yaman, M . (2020). Vitamin C ve Hastalıklar Üzerine Etkisi . Avrupa Bilim ve Teknoloji Dergisi , (19) , 746-756 . Retrieved from https://dergipark.org.tr/en/pub/ejosat/issue/54511/735440