Year 2020, Volume , Issue 20, Pages 147 - 151 2020-12-31

Selenyum ve Selenyumun Depresyon Üzerine Etkileri

Burcu USLU [1] , Sule AKTAC [2]


Sağlığı korumak, hastalığı önlemek ve yaşlanma sürecini yavaşlatmak için yeterli dozlarda günlük Selenyum alımı gerekmektedir. Selenyum; redoks homeostazını, tiroid hormon metabolizmasını etkileyen, oksidatif stres ve inflamasyondan koruyan geniş bir pleiotropik etki alanına sahip eser elementtir. İnsanlar için hayati öneme sahip olmakla birlikte, doz ve spesifikasyona bağlı olarak toksik olabilecek bir elementtir. Diğer birçok besinde de olduğu gibi, selenyuma verilen biyolojik yanıtın cinsiyete, selenoprotein genlerindeki nükleotid polimorfizmlerine, bireydeki mevcut Se durumuna, bireyin yaşına ve hastalığın varlığına bağlı olduğu düşünülmelidir. Selenyumun aktif parçacığı selenosisteinlerdir. İnsanlarda selenyumun beslenme kaynaklı fonksiyonlar, selenosistein bulunduran, selenoproteinler ile sağlanır. Selenoproteinlerin metabolizmadaki rolünün bilinmesi, selenyumun insan sağlığı üzerindeki sonuçlarını açıklamaya yardımcı olur. Glutatyon peroksidaz hayvanlardaki çoğu dokuda bulunan ana selenoproteindir. Antioksidan savunma teorileri arasında glutatyon peroksidazlar gibi selenoproteinlerin önemli bir rol oynadığı düşünülmektedir. Selenoproteinlerin biyosentezi, temel eser element selenyumunun mevcudiyetine bağlıdır. Böylece, selenyumun yeterli alımı, beyin fonksiyonunun korunması için önemlidir. Selenyum eksikliği, kalp ve nöromüsküler bozukluklar dahil olmak üzere birçok patofizyolojik durumu ortaya çıkarabilir. Depresyon için yeterli tedavi seçeneği varken bireylerin önemli bir kısmı hala iyileşme sağlayamamaktadır. Bu nedenle, değiştirilebilir risk faktörlerini ve depresyon önleyici etkili yöntemleri araştırmak gerekmektedir. Selenyumun nöroprotektif etkisi henüz kesin olarak tanımlanmamasına rağmen, selenyumun duygu durum bozukluğundaki koruyucu rolü antioksidan savunmadaki önemli etkisiyle ilişkili olabilir. Bu derleme selenyumun depresyon ve diğer depresyon çeşitleri üzerine etkisini inceleme amacıyla yapılmıştır.
Selenyum, Depresyon, Oksidatif Stres
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Primary Language tr
Subjects Engineering
Journal Section Articles
Authors

Orcid: 0000-0002-6371-6562
Author: Burcu USLU (Primary Author)
Institution: YÜKSEK İHTİSAS ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0002-2158-5015
Author: Sule AKTAC
Institution: MARMARA ÜNİVERSİTESİ
Country: Turkey


Dates

Publication Date : December 31, 2020

APA Uslu, B , Aktac, S . (2020). Selenyum ve Selenyumun Depresyon Üzerine Etkileri . Avrupa Bilim ve Teknoloji Dergisi , (20) , 147-151 . DOI: 10.31590/ejosat.757344