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Effects of Supplementation with Rumen-Protected Choline and Methionine on Metabolic Profile and Some Reproductive Parameters in Dairy Cattle During Transition Period

Year 2022, Issue: 35, 474 - 481, 07.05.2022
https://doi.org/10.31590/ejosat.1088990

Abstract

This study conducted to determine effect of the rumen-protected choline and methionine supplementation to peripartum dairy cattle on metabolic profile, metabolic disorders and some reproductive parameters. For this, 3-6 year-old, multiparous, healthy and pregnant 32 high-yield Holstein dairy cows were divided into 4 different groups during trial as: a control (CON) group with no supplementation to the ration; a 75 gr/day rumen-protected choline chloride (CHOL) supplemented group, 42 gr/ day methionine (MET) supplemented group, 75 gr/ day choline chloride and 42 gr/ day methionine (MET + CHOL) supplemented group were during three weeks before and after parturation. Blood samples were taken at wk -3, calving, wk 3 and wk 10 and were analyzed. Health problems and reproductive data were recorded during treatment. Statistically significant differences were detected in non-esterified fatty acids (NEFA), insulin like growth factor-1 (IGF-1), glucose, total protein, albumin, direct bilirubin, total cholesterol and very low density lipoproteins (VLDL). Results of this study suggested that rumen-protected choline and methionine supplementation to the rations of dairy cattle affected some metabolic profile parameters. The statistical differences in metabolic profile tests did not affect metabolic diseases and reproductive parameters.

Supporting Institution

Uludag University Scientific Research Unit Grant

Project Number

OUAP (V)-2014/4

References

  • AOAC (Association of Official Analytic Chemists) 1990. Official Methods of Analysis of AOAC International. 15th ed., AOAC, USA.
  • Ardalan, M., Rezayazdi, K., Dehghan-Banadaky, M. 2009. Investigation on the Effect of Supplementing Rumen-Protected Forms of Methionin and Choline on Health Situation and Reproductive Performance of Holstein Dairy Cows. Pakistan Journal of Biology Science, 12, 69-73.
  • Bell, A. W. 1995. Regulation of organic nutrient metabolism during transition from late pregnancy to early lactation. Journal of Animal Science, 73, 2804-2819.
  • Cetin, I., Turkmen, I. I., Kara, C., Orman, A., Sen, E. 2018. Improved lactational performance in dairy cows supplemented with methionine or rumen-protected choline during the transition period. Kafkas Universitesi Veteriner Fakultesi Dergisi, 24(2), 289-293.
  • Cooke, R. F., Silva del Rio, N., Caraviello, D. Z., Bertics, S. J., Ramos, M. H., Grummer, R. R. 2007. Supplemental Choline for Preventation and Alleviation of Fatty Liver in Dairy Cattle. Journal of Dairy Science, 90, 2413-2418.
  • Chung, Y. H., Brown, N. E., Martinez, C. M., Cassidy, T. W., Varga, G. A. 2009. Effects of rumen- protected choline and dry propylene glycol on feed intake and blood parameters for Holstein dairy cows in early lactation. Journal of Dairy Science, 92, 2729-2736.
  • Drackley, J. K., Andersen, J. B. 2006. Splanchnic metabolism of long-chain fatty acids in ruminants. Pages 199-224 in Ruminant Physiology: Digestion, Metabolism and Impact of Nutrition on Gene Expression, Immunology and Stress. K. Sejrsen, T. Hvelplund and M.O. Nielsen ed. Wageningen Academic Publishers Wageningen, the Netherlands.
  • Farid, A. S., 2013. Honkawa K, Fath EM, Nonaka N, Harii Y: Serum paraoxonase-1 as biomarker for improved diagnosis of fatty liver in dairy cows. BMC Veterinary Research, 9, 73.
  • Hartwell, J. R., Cecava, M. J., Donkin, S. S. 2000. Impact of dietary rumen undegradable protein and rumen-protected choline on intake, peripartum triacylglyceride, plasma metabolites and milk production in transition dairy cows. Journal of Dairy Science, 83, 2907-2917.
  • Humer, E., Bruggeman, G., Zebeli, Q. 2019. A meta-analysis on the impact of the supplementation of rumen-protected choline on the metabolic health and performance of dairy cattle. Animals, 9, 566.
  • Janovick Guretzky, N. A., Carlson, D. B., Garrett, J. E., Drackley, J. K. 2006. Lipid metabolite profiles and milk production for Holstein and Jersey cows Fed Rumen-Protected Choline during the periparturient period. Journal of Dairy Science, 89, 188-200.
  • Jorritsma, R., Jorritsma, H., Schukken, Y. H., Wentink, G. H. 2000. Relationships between fatty liver and fertility and some periparturient diseases in commercial Dutch dairy herds. Theriogenology, 54(7), 1065-1074.
  • Leiva, T., Cooke, R. F., Brandao, A. P., Marques, R. S., Vasconcelos, J. L. 2015. Effects of rumen-protected choline supplementation on metabolic and performance responses of transition dairy cows. Journal of Animal Science, 93, 1896-1904.
  • Lima, F. S., Sa Filho, M. F., Greco, L. F., Santos, J. E. 2012. Effects of feeding rumen-protected choline on incidence of diseases and reproduction of dairy cows. The Veterinary Journal, 193, 140-145.
  • McGuffey, R.K. 2017. A 100-year review: Metabolic modifiers in dairy cattle nutrition. Journal of Dairy Science, 100, 10113-10142.
  • NRC (National Research Council) 2001. Nutrient Requirements of Dairy Cattle. 7th revised edition, National Academy Press, Washington, DC.
  • Osorio, J. S., Ji, P.,Drackley, J. K., Luchini D., Loor J. J. 2014. Smartamine M and MetaSmart supplementation during the peripartal period alter hepatic expression of gene networks in 1-carbon metabolism, inflammation, oxidative stress, and the growth hormone-insulin-like growth factor 1 axis pathways. Journal of Dairy Science, 97, 7451–7464.
  • Osorio, J. S., Trevisi, E., Ji, P., Drackley, J. K., Luchini, D., Bertoni, G., Loor, J. J. 2014. Biomarkers of inflammation, metabolism, and oxidative stress in blood, liver, and milk reveal a better immunometabolic status in peripartal cows supplemented with Smartamine M or MetaSmart. Journal of Dairy Science, 97(12), 7437–7450.
  • Osorio, J. S., Ji, P., Drackley, J. K., Luchini, D., Loor, J. J. 2013. Suplemental Smartamine M or MetaSmart during the transition period benefits postpartal cow performance and blood neutrophil function. Journal of Dairy Science, 96, 6248-6263.
  • Overton, T. R., Waldron, M. R. 2004. Nutritional management of transition dairy cows: Strategies to optimize metabolic health. Journal of Dairy Science, 87, 105-119.
  • Piepenbrink, M. S., Marr, A. L., Waldron, M. R., Butler, W. R., Overton, T. R., Vazquez-Anon, M., Holt, M. D. 2004. Feeding 2-Hydroxy-4-(Methylthio)-Butanoic acid to periparturient dairy cows improves milk production but not hepatic metabolism. Journal of Dairy Science, 87, 1071-1084.
  • Pinotti, L., Baldi, A., Dell’Orto, V. 2002. Comparative mammalian choline metabolism with emphasis on the high-yielding dairy cow. Nutrition Research Reviews, 15, 315-332.
  • Rukkwamsuk, T., Wensing, T., Krup, T. A. M. 1999. Relationship between triacylglycerol concentration in the liver and first ovulation in postpartum dairy cows. Theriogenology, 51, 1133-1142.
  • Shahsavari, A., D’Occhio, M. J., Al Jassim, R. 2016. The role of rumen-protected choline in hepatic function and performance of transition cows. British Journal of Nutrition, 116, 35-44.
  • Soltan, M. A., Mujalli, A. M., Mandour, M. A., Al-Shinway Abeer, M. 2012 Effect of Dietary Rumen Pretected Methionine and/or Choline Supplementation on Rumen Fermentation Characteristicss and Productive Performance of Early Lactating Cows. Pakistan Journal of Nutrition, 11, 221-230.
  • SPSS (Statistical Package for the Social Science) 2011. Base system user’s guide, version 20.0. SPSS, Armonk, NY, IBM Corp, USA.
  • Stein, E. A., Myers, G. L. 1994. Lipids, lipoproteins and apolipoproteins. In, Burtis CA, Ashwood ER (Eds): Tietz of Texbook of Clinical Chemistry. Second ed. p.1055, WB Saunders Company, Philadelphia.
  • Strzetelski, J. A., Kowalski, Z. M., Kowalczyk, J., Borowiec, F., Osieglowski, S., Slusarczyk, K. 2009. Protected methionine as a methyl-group donor for dairy cows fed diets with different starch sources in the transition period. Journal of Animal Feed Sciences, 18(1), 28-41.
  • Sundaram, M., Yao, Z. 2010. Recent Progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion. Nutrition & Metabolism, 7, 35.
  • Toledo, M. Z., Baez, G. M., Garcia-Guerra, A., Lobos, N. E,, Guenther, J. N., Trevisol, E., Luchini, D., Shaver, R. D., Wiltbank, M. C. 2017. Effect of feeding rumen-protected methionine on productive and reproductive performance of dairy cows. PLoS ONE 12(12), e0189117.
  • Vailati-Riboni, M., Osorio, S. J., Trevisi, E., Luchini, D., Loor, J. J. 2017. Supplemental Smartamine M in higher-energy diets during the prepartal period improves hepatic biomarkers of health and oxidative status in Holstein cows. Journal of Animal Science and Biotechnology, 8, 17.
  • Vance, J. E. 2002. Assembly and secretion of lipoproteins. New Comprrehensive Biochemistry, 36, 502-526.
  • Van Soest, P. J., Robertson, J. B., Lewis, B. A. 1991. Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. Journal of Dairy Science, 74(10), 3583–3597.
  • Xu, G., Ye, J., Liu, J., Yu, Y. 2006. Effect of Rumen-protected Choline Addition on Milk Performance and Blood Metabolic Parameters in Transition Dairy Cows. Asian-Australasian Journal of Animal Sciences, 19(3), 390-395.
  • Zahra, L. C., Duffield, T. F., Leslie, K. E., Overton, T. R., Putnam, D., LeBlanc, S. J. 2006. Effects of rumen-protected choline and monensin on milk production and metabolism of periparturient dairy cows. Journal of Dairy Science, 89, 4808-4818.
  • Zhou, Z., Bulgari, O., Vailati-Riboni, M., Trevisi, E., Ballou, M. A., Cardoso, F. C., Luchini, D. N., Loor, J. J. 2016. Rumen-protected methionine compared with rumen-protected choline improves immunometabolic status in dairy cows during the peripartal period. J Dairy Sci, 99(11), 8956–8969.
  • Zhou, Z., Vailati-Riboni, M., Trevisi, E., Drackley, J. K., Luchini, D. N., Loor, J. J. 2016. Better postpartal performance in dairy cows supplemented with rumen protected methionine compared with choline during the peripartal period. Journal of Dairy Science, 99, 8716-8732.
  • Zom, R. L., van Baal, J., Goselink, R. M., Bakker, J. A., de Veth, M. J.,van Vuuren, A. M. 2011. Effect of rumen-protected choline on performance, blood metabolites, and hepatic triacylglycerols of periparturient dairy cattle. Journal of Dairy Science, 94, 4016-4027.

Geçiş Dönemindeki Süt Sığırlarında Korunmuş Kolin ve Metiyonin İlavesinin Metabolik Profil ve Bazı Üreme Parametreleri Üzerine Etkileri

Year 2022, Issue: 35, 474 - 481, 07.05.2022
https://doi.org/10.31590/ejosat.1088990

Abstract

Bu çalışma, korunmuş kolin ve metiyonin ilavesinin peripartum süt sığırlarda metabolik profil, metabolik hastalıklar ve bazı üreme parametreleri üzerine etkisini belirlemek amacıyla yapılmıştır. Araştırmada, 3-6 yaş arası, en az bir doğum yapmış, sağlıklı ve gebe 32 baş yüksek verimli Holştayn ırkı süt sığırı kullanıldı. Süt sığırları 4 farklı gruba ayrılarak, kontrol (KON) grubunda yer alan süt sığırlarının rasyonlarına deneme süresince herhangi bir katkı yapılmazken, kolin klorür (KOL) grubundaki süt sığırlarının rasyonlarına doğum öncesi 3 hafta ve doğum sonrası 3 hafta boyunca 75 gr/gün dozunda korunmuş formda kolin klorür, metiyonin (MET) grubundaki süt sığırlarının rasyonlarına ise 42 gr/gün dozunda korunmuş formda metiyonin, Metiyonin ve Kolin Klorür (MET + KOL) grubunda yer alan sığırlarada 75 gr/gün dozunda korunmuş formda kolin klorür ve 42 gr/gün dozunda korunmuş formda metiyonin ilave edildi. Kan örnekleri doğumdan önce 3. hafta, doğumda ve doğumdan sonra 3. ve 10. haftalarda alındı ve ticari kitlerle analiz edildi. Araştırma esnasında sağlık sorunları ve üreme verileri kaydedildi. NEFA, IGF-1, glikoz, total protein, albumin, direkt bilurubin, total kolestrol ve çok düşük dansiteli lipoproteinlerde istatistiksel olarak anlamlı farklılıklar tespit edildi. Bu araştırmanın sonucunda, süt sığırlarının rasyonlarına korunmuş kolin ve metiyonin ilavesinin bazı metabolik profil parametrelerini etkilediğini göstermiştir. Metabolik profil testlerindeki istatistiksel farklılıklar, metabolik hastalıklar ve üreme parametrelerini etkilemedi.

Project Number

OUAP (V)-2014/4

References

  • AOAC (Association of Official Analytic Chemists) 1990. Official Methods of Analysis of AOAC International. 15th ed., AOAC, USA.
  • Ardalan, M., Rezayazdi, K., Dehghan-Banadaky, M. 2009. Investigation on the Effect of Supplementing Rumen-Protected Forms of Methionin and Choline on Health Situation and Reproductive Performance of Holstein Dairy Cows. Pakistan Journal of Biology Science, 12, 69-73.
  • Bell, A. W. 1995. Regulation of organic nutrient metabolism during transition from late pregnancy to early lactation. Journal of Animal Science, 73, 2804-2819.
  • Cetin, I., Turkmen, I. I., Kara, C., Orman, A., Sen, E. 2018. Improved lactational performance in dairy cows supplemented with methionine or rumen-protected choline during the transition period. Kafkas Universitesi Veteriner Fakultesi Dergisi, 24(2), 289-293.
  • Cooke, R. F., Silva del Rio, N., Caraviello, D. Z., Bertics, S. J., Ramos, M. H., Grummer, R. R. 2007. Supplemental Choline for Preventation and Alleviation of Fatty Liver in Dairy Cattle. Journal of Dairy Science, 90, 2413-2418.
  • Chung, Y. H., Brown, N. E., Martinez, C. M., Cassidy, T. W., Varga, G. A. 2009. Effects of rumen- protected choline and dry propylene glycol on feed intake and blood parameters for Holstein dairy cows in early lactation. Journal of Dairy Science, 92, 2729-2736.
  • Drackley, J. K., Andersen, J. B. 2006. Splanchnic metabolism of long-chain fatty acids in ruminants. Pages 199-224 in Ruminant Physiology: Digestion, Metabolism and Impact of Nutrition on Gene Expression, Immunology and Stress. K. Sejrsen, T. Hvelplund and M.O. Nielsen ed. Wageningen Academic Publishers Wageningen, the Netherlands.
  • Farid, A. S., 2013. Honkawa K, Fath EM, Nonaka N, Harii Y: Serum paraoxonase-1 as biomarker for improved diagnosis of fatty liver in dairy cows. BMC Veterinary Research, 9, 73.
  • Hartwell, J. R., Cecava, M. J., Donkin, S. S. 2000. Impact of dietary rumen undegradable protein and rumen-protected choline on intake, peripartum triacylglyceride, plasma metabolites and milk production in transition dairy cows. Journal of Dairy Science, 83, 2907-2917.
  • Humer, E., Bruggeman, G., Zebeli, Q. 2019. A meta-analysis on the impact of the supplementation of rumen-protected choline on the metabolic health and performance of dairy cattle. Animals, 9, 566.
  • Janovick Guretzky, N. A., Carlson, D. B., Garrett, J. E., Drackley, J. K. 2006. Lipid metabolite profiles and milk production for Holstein and Jersey cows Fed Rumen-Protected Choline during the periparturient period. Journal of Dairy Science, 89, 188-200.
  • Jorritsma, R., Jorritsma, H., Schukken, Y. H., Wentink, G. H. 2000. Relationships between fatty liver and fertility and some periparturient diseases in commercial Dutch dairy herds. Theriogenology, 54(7), 1065-1074.
  • Leiva, T., Cooke, R. F., Brandao, A. P., Marques, R. S., Vasconcelos, J. L. 2015. Effects of rumen-protected choline supplementation on metabolic and performance responses of transition dairy cows. Journal of Animal Science, 93, 1896-1904.
  • Lima, F. S., Sa Filho, M. F., Greco, L. F., Santos, J. E. 2012. Effects of feeding rumen-protected choline on incidence of diseases and reproduction of dairy cows. The Veterinary Journal, 193, 140-145.
  • McGuffey, R.K. 2017. A 100-year review: Metabolic modifiers in dairy cattle nutrition. Journal of Dairy Science, 100, 10113-10142.
  • NRC (National Research Council) 2001. Nutrient Requirements of Dairy Cattle. 7th revised edition, National Academy Press, Washington, DC.
  • Osorio, J. S., Ji, P.,Drackley, J. K., Luchini D., Loor J. J. 2014. Smartamine M and MetaSmart supplementation during the peripartal period alter hepatic expression of gene networks in 1-carbon metabolism, inflammation, oxidative stress, and the growth hormone-insulin-like growth factor 1 axis pathways. Journal of Dairy Science, 97, 7451–7464.
  • Osorio, J. S., Trevisi, E., Ji, P., Drackley, J. K., Luchini, D., Bertoni, G., Loor, J. J. 2014. Biomarkers of inflammation, metabolism, and oxidative stress in blood, liver, and milk reveal a better immunometabolic status in peripartal cows supplemented with Smartamine M or MetaSmart. Journal of Dairy Science, 97(12), 7437–7450.
  • Osorio, J. S., Ji, P., Drackley, J. K., Luchini, D., Loor, J. J. 2013. Suplemental Smartamine M or MetaSmart during the transition period benefits postpartal cow performance and blood neutrophil function. Journal of Dairy Science, 96, 6248-6263.
  • Overton, T. R., Waldron, M. R. 2004. Nutritional management of transition dairy cows: Strategies to optimize metabolic health. Journal of Dairy Science, 87, 105-119.
  • Piepenbrink, M. S., Marr, A. L., Waldron, M. R., Butler, W. R., Overton, T. R., Vazquez-Anon, M., Holt, M. D. 2004. Feeding 2-Hydroxy-4-(Methylthio)-Butanoic acid to periparturient dairy cows improves milk production but not hepatic metabolism. Journal of Dairy Science, 87, 1071-1084.
  • Pinotti, L., Baldi, A., Dell’Orto, V. 2002. Comparative mammalian choline metabolism with emphasis on the high-yielding dairy cow. Nutrition Research Reviews, 15, 315-332.
  • Rukkwamsuk, T., Wensing, T., Krup, T. A. M. 1999. Relationship between triacylglycerol concentration in the liver and first ovulation in postpartum dairy cows. Theriogenology, 51, 1133-1142.
  • Shahsavari, A., D’Occhio, M. J., Al Jassim, R. 2016. The role of rumen-protected choline in hepatic function and performance of transition cows. British Journal of Nutrition, 116, 35-44.
  • Soltan, M. A., Mujalli, A. M., Mandour, M. A., Al-Shinway Abeer, M. 2012 Effect of Dietary Rumen Pretected Methionine and/or Choline Supplementation on Rumen Fermentation Characteristicss and Productive Performance of Early Lactating Cows. Pakistan Journal of Nutrition, 11, 221-230.
  • SPSS (Statistical Package for the Social Science) 2011. Base system user’s guide, version 20.0. SPSS, Armonk, NY, IBM Corp, USA.
  • Stein, E. A., Myers, G. L. 1994. Lipids, lipoproteins and apolipoproteins. In, Burtis CA, Ashwood ER (Eds): Tietz of Texbook of Clinical Chemistry. Second ed. p.1055, WB Saunders Company, Philadelphia.
  • Strzetelski, J. A., Kowalski, Z. M., Kowalczyk, J., Borowiec, F., Osieglowski, S., Slusarczyk, K. 2009. Protected methionine as a methyl-group donor for dairy cows fed diets with different starch sources in the transition period. Journal of Animal Feed Sciences, 18(1), 28-41.
  • Sundaram, M., Yao, Z. 2010. Recent Progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion. Nutrition & Metabolism, 7, 35.
  • Toledo, M. Z., Baez, G. M., Garcia-Guerra, A., Lobos, N. E,, Guenther, J. N., Trevisol, E., Luchini, D., Shaver, R. D., Wiltbank, M. C. 2017. Effect of feeding rumen-protected methionine on productive and reproductive performance of dairy cows. PLoS ONE 12(12), e0189117.
  • Vailati-Riboni, M., Osorio, S. J., Trevisi, E., Luchini, D., Loor, J. J. 2017. Supplemental Smartamine M in higher-energy diets during the prepartal period improves hepatic biomarkers of health and oxidative status in Holstein cows. Journal of Animal Science and Biotechnology, 8, 17.
  • Vance, J. E. 2002. Assembly and secretion of lipoproteins. New Comprrehensive Biochemistry, 36, 502-526.
  • Van Soest, P. J., Robertson, J. B., Lewis, B. A. 1991. Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. Journal of Dairy Science, 74(10), 3583–3597.
  • Xu, G., Ye, J., Liu, J., Yu, Y. 2006. Effect of Rumen-protected Choline Addition on Milk Performance and Blood Metabolic Parameters in Transition Dairy Cows. Asian-Australasian Journal of Animal Sciences, 19(3), 390-395.
  • Zahra, L. C., Duffield, T. F., Leslie, K. E., Overton, T. R., Putnam, D., LeBlanc, S. J. 2006. Effects of rumen-protected choline and monensin on milk production and metabolism of periparturient dairy cows. Journal of Dairy Science, 89, 4808-4818.
  • Zhou, Z., Bulgari, O., Vailati-Riboni, M., Trevisi, E., Ballou, M. A., Cardoso, F. C., Luchini, D. N., Loor, J. J. 2016. Rumen-protected methionine compared with rumen-protected choline improves immunometabolic status in dairy cows during the peripartal period. J Dairy Sci, 99(11), 8956–8969.
  • Zhou, Z., Vailati-Riboni, M., Trevisi, E., Drackley, J. K., Luchini, D. N., Loor, J. J. 2016. Better postpartal performance in dairy cows supplemented with rumen protected methionine compared with choline during the peripartal period. Journal of Dairy Science, 99, 8716-8732.
  • Zom, R. L., van Baal, J., Goselink, R. M., Bakker, J. A., de Veth, M. J.,van Vuuren, A. M. 2011. Effect of rumen-protected choline on performance, blood metabolites, and hepatic triacylglycerols of periparturient dairy cattle. Journal of Dairy Science, 94, 4016-4027.
There are 38 citations in total.

Details

Primary Language English
Subjects Engineering
Journal Section Articles
Authors

İsmail Çetin 0000-0001-7589-4852

İsmet Türkmen 0000-0002-8111-7619

Çağdaş Kara 0000-0003-2515-1211

Duygu Udum 0000-0001-7052-1694

Abdülkadir Orman 0000-0001-9138-4422

Hıdır Gençoğlu 0000-0003-1067-2874

Project Number OUAP (V)-2014/4
Publication Date May 7, 2022
Published in Issue Year 2022 Issue: 35

Cite

APA Çetin, İ., Türkmen, İ., Kara, Ç., Udum, D., et al. (2022). Effects of Supplementation with Rumen-Protected Choline and Methionine on Metabolic Profile and Some Reproductive Parameters in Dairy Cattle During Transition Period. Avrupa Bilim Ve Teknoloji Dergisi(35), 474-481. https://doi.org/10.31590/ejosat.1088990