Nikotinik Asit ve Türevleri İle Krom (III) İyonunun Oluşturduğu Komplekslerin Kararlılıkları
Year 2023,
Issue: 52, 136 - 143, 15.12.2023
Mehmet Suat Aksoy
Abstract
Cr(III)’ün NA, 2-ANA ve 4-ANA ile farklı mol oranlarında (1:1 ve 1:2) potansiyometrik titrasyonları yapıldı. Gerçekleşen kompleks iyon ve bileşiklerinin stokiyometrileri ve kararlılık sabitleri bulundu. Cr(III)’ün NA, 2-ANA ve 4-ANA ile CrL2+, CrL2+, CrL(OH)+ ve CrL2(OH) türü kompleks iyon ve bileşiklerini oluşturduğu saptandı.
Supporting Institution
Bursa Uludağ Üniversitesi Bilimsel Araştırma Projeleri Birimi
Thanks
UAP(F)-70 projesine maddi desteğinden dolayı Bursa Uludağ Üniversitesi Bilimsel Araştırma Projeleri Birimine teşekkür ederiz.
References
- Aksoy M S, Özer U, 2003. Potentiometric and spectroscopic studies with chromium(III) complexes of hydroxysalicylic acid derivatives in aqueous solution. Turk. J. Chem., 27 (6): 667–673.
- Aksoy M S, Özer U, 2004. Equilibrium studies on chromium(III) complexes of salicylic acid and salicylic acid derivatives in aqueous
solution. Chem. Pharm. Bull., 52 (11): 1280–1284.
- Aksoy M S, Aydın R, Türkel N, Özer U, 2005.Formation constants of chromium(III), scandium(III) and yttrium (III) complexes of some
hydroxynaphthoic acids. Chem. Pharm. Bull., 53 (5): 471–475.
- Aksoy M S, 2008. Complexes of chromium(III) with 2,3-dihydroxynaphthalene-6-sulfonic acid and 4,5-dihydroxynaphthalene-2,7-
disulfonic acid in aqueous solution. Chem. Pharm. Bull., 56 (6): 771- 774.
- Aksoy M S, 2009. Formation constants of chromium(III) complexes with 8-hydroxyquinoline and 8-hydroxyquinoline-5-sulfonic acid.
Asian J. Chem., 21 (7):5189–5198.
- Aksoy M S, 2010. Study of the Interaction Between Chromium(III) and Hydroxamic Acids, Journal of Chemical and Engineering Data,
55(6): 2252-2256.
- Ali M A, Kadir M H, Nazimuddin M, Majumder S M M, Tarafder M T H, Khair M A, 1988. Indian J. Chem. Sect., A 27:1064.
- Aman S, Chishti K A, Mahmood F, 2018. Potential Effect of Nicotinic Acid Derivatives on Brain Monoamines in Male Albino Mice.
Latin American Journal of Pharmacy, 37(11): 2185-2190.
- Bartzatt R, Grillo S L G, Grillo J D, 2007. Antibacterial activity of dipeptide constructs of acetylsalicylic acid and nicotinic acid. Drug
Delivery, 14(2): 105-109.
- Chohan Z H, Rauf A, Supuran C T, 2002. Antibacterial cobalt(II), nickel(II) and zinc(II) complexes of nicotinic acid-derived Schiff-
bases, Journal of Enzyme Inhibition and Medicinal Chemistry, 17(2): 101-106.
- Cotton F A, Wilkinson G, Murillo C A, and Bochmann M, 1999. Advanced Inorganic Chemistry, 6th ed. John Wiley, New York.
- Cox M, Lehninger A L, Nelson D R, 2000. Lehninger Principles of Biochemistry. 3rd Edition, New York Worth Publishers, USA, pp:
380-381.
- Fedorov B S, Fadeev M A, Blokhina S V, 2009. Synthesis and antimetastatic activity of metal complexes based on substituted
pyridinecarboxylic acid amides and platinum tetrachloride. Pharmaceutical Chemistry Journal, 43(3): 134-138.
- Gonçalves M E, Abhinav J. et al., 2011. Potentiometric Titration Study of the Temperature and Ionic Strength Dependence of the
Acidity Constants of Nicotinic Acid (Niacin). J. Chem. Eng. Data, 56: 2964-2970.
- Lin Y S, Chen S H, Hou W C, 2012. Effects of nicotinic acid derivatives on tyrosinase inhibitory and antioxidant activities, 132(4):
2074-2080.
- Makhmudov A A, 2020. Synthesis and Biological Activity of Sulfamido and Alkoxycarbonyl-substituted Nicotinic Acid Esters,
Russian Journal of Organic Chemistry, 56(2): 246-250.
- Mansoori M H, Khatik G L and Mishra V, 2018. Synthesis and pharmacological evaluation of pyridinyl-1,3,4-oxadiazolyl-ethanone
derivatives as antimicrobial, antifungal and antitubercular agents, Medicinal Chemistry Research, 27(3): 744-755.
- Marszalek D, Goldnik A, Kumorowska S, 2014. Stability of new anticonvulsant derivatives of picolinic, nicotinic, cyclocarboxylic
acids in body fluids and tissues. Acta Poloniae Pharmaceutica, 71(2): 261-264.
- Morsy Abu-Youssef A M, Dey R, Gohar Y, Massoud A A, Ohrstrom L, Langer V, 2007. Inorg. Chem., 46: 5893–5903.
- Robert M S, and, Martel A E, 1989. Critical Stability Constants. Plenum Press, New York.
- Shimai T, Islam M T, Fukushi Y, Hashidoko Y, Yokosawa R, Tahara S Z, 2002. Naturforsch, 57: 323-331.
Sinthupoom N, Prachayasittikul V, 2015. Nicotinic acid and derivatives as multifunctional pharmacophores for medical applications,
240(1): 1-17.
Stability of Complexes Formed by Chromium(III) Ion with Nicotinic Acid and Derivatives
Year 2023,
Issue: 52, 136 - 143, 15.12.2023
Mehmet Suat Aksoy
Abstract
Potentiometric titrations of Cr(III) with NA, 2-ANA and 4-ANA in different molar ratios (1:1 and 1:2) were performed. The stoichiometry and stability constants of the complex ions and compounds were found. It was determined that chromium(III) forms complex ions and compounds such as CrL2+, CrL2+, CrL(OH)+ and CrL2(OH).
References
- Aksoy M S, Özer U, 2003. Potentiometric and spectroscopic studies with chromium(III) complexes of hydroxysalicylic acid derivatives in aqueous solution. Turk. J. Chem., 27 (6): 667–673.
- Aksoy M S, Özer U, 2004. Equilibrium studies on chromium(III) complexes of salicylic acid and salicylic acid derivatives in aqueous
solution. Chem. Pharm. Bull., 52 (11): 1280–1284.
- Aksoy M S, Aydın R, Türkel N, Özer U, 2005.Formation constants of chromium(III), scandium(III) and yttrium (III) complexes of some
hydroxynaphthoic acids. Chem. Pharm. Bull., 53 (5): 471–475.
- Aksoy M S, 2008. Complexes of chromium(III) with 2,3-dihydroxynaphthalene-6-sulfonic acid and 4,5-dihydroxynaphthalene-2,7-
disulfonic acid in aqueous solution. Chem. Pharm. Bull., 56 (6): 771- 774.
- Aksoy M S, 2009. Formation constants of chromium(III) complexes with 8-hydroxyquinoline and 8-hydroxyquinoline-5-sulfonic acid.
Asian J. Chem., 21 (7):5189–5198.
- Aksoy M S, 2010. Study of the Interaction Between Chromium(III) and Hydroxamic Acids, Journal of Chemical and Engineering Data,
55(6): 2252-2256.
- Ali M A, Kadir M H, Nazimuddin M, Majumder S M M, Tarafder M T H, Khair M A, 1988. Indian J. Chem. Sect., A 27:1064.
- Aman S, Chishti K A, Mahmood F, 2018. Potential Effect of Nicotinic Acid Derivatives on Brain Monoamines in Male Albino Mice.
Latin American Journal of Pharmacy, 37(11): 2185-2190.
- Bartzatt R, Grillo S L G, Grillo J D, 2007. Antibacterial activity of dipeptide constructs of acetylsalicylic acid and nicotinic acid. Drug
Delivery, 14(2): 105-109.
- Chohan Z H, Rauf A, Supuran C T, 2002. Antibacterial cobalt(II), nickel(II) and zinc(II) complexes of nicotinic acid-derived Schiff-
bases, Journal of Enzyme Inhibition and Medicinal Chemistry, 17(2): 101-106.
- Cotton F A, Wilkinson G, Murillo C A, and Bochmann M, 1999. Advanced Inorganic Chemistry, 6th ed. John Wiley, New York.
- Cox M, Lehninger A L, Nelson D R, 2000. Lehninger Principles of Biochemistry. 3rd Edition, New York Worth Publishers, USA, pp:
380-381.
- Fedorov B S, Fadeev M A, Blokhina S V, 2009. Synthesis and antimetastatic activity of metal complexes based on substituted
pyridinecarboxylic acid amides and platinum tetrachloride. Pharmaceutical Chemistry Journal, 43(3): 134-138.
- Gonçalves M E, Abhinav J. et al., 2011. Potentiometric Titration Study of the Temperature and Ionic Strength Dependence of the
Acidity Constants of Nicotinic Acid (Niacin). J. Chem. Eng. Data, 56: 2964-2970.
- Lin Y S, Chen S H, Hou W C, 2012. Effects of nicotinic acid derivatives on tyrosinase inhibitory and antioxidant activities, 132(4):
2074-2080.
- Makhmudov A A, 2020. Synthesis and Biological Activity of Sulfamido and Alkoxycarbonyl-substituted Nicotinic Acid Esters,
Russian Journal of Organic Chemistry, 56(2): 246-250.
- Mansoori M H, Khatik G L and Mishra V, 2018. Synthesis and pharmacological evaluation of pyridinyl-1,3,4-oxadiazolyl-ethanone
derivatives as antimicrobial, antifungal and antitubercular agents, Medicinal Chemistry Research, 27(3): 744-755.
- Marszalek D, Goldnik A, Kumorowska S, 2014. Stability of new anticonvulsant derivatives of picolinic, nicotinic, cyclocarboxylic
acids in body fluids and tissues. Acta Poloniae Pharmaceutica, 71(2): 261-264.
- Morsy Abu-Youssef A M, Dey R, Gohar Y, Massoud A A, Ohrstrom L, Langer V, 2007. Inorg. Chem., 46: 5893–5903.
- Robert M S, and, Martel A E, 1989. Critical Stability Constants. Plenum Press, New York.
- Shimai T, Islam M T, Fukushi Y, Hashidoko Y, Yokosawa R, Tahara S Z, 2002. Naturforsch, 57: 323-331.
Sinthupoom N, Prachayasittikul V, 2015. Nicotinic acid and derivatives as multifunctional pharmacophores for medical applications,
240(1): 1-17.