Neutropenia Induced by Drugs Used in Psychiatric Treatment: A Case Report

Year 2022, Volume: 4 Issue: 2, 57 - 58, 30.08.2022

Liljana Mehmetaj , Yasin Ugur , Bahadir Taslidere , Ertan Sonmez , Basar Cander

https://doi.org/10.51262/ejtox.1162734

Abstract

Changes in blood parameters may occur during the use of psychiatric drugs. In such cases, the general condition of the patient and the blood parameters are closely monitored and the treatment is discontinued or the medication is changed. The purpose of this case report was to be alert to the possibility of side effects such as neutropenia due to antipsychotic drugs and to draw attention to the management of these patients

Keywords

Antipsychotic medications , Antiepileptic drugs , Neutropenia

Project Number

yok

Psikiyatrik Tedavide Kullanılan İlaçların Neden Olduğu Nötropeni: Bir Olgu Sunumu

Abstract

Psikiyatrik ilaçların kullanımı sırasında kan parametrelerinde değişiklikler meydana gelebilir. Bu gibi durumlarda hastanın genel durumu ve kan parametreleri yakından takip edilerek tedavi kesilir veya ilaç değiştirilir. Bu vaka raporunun amacı, antipsikotik ilaçlara bağlı nötropeni gibi yan etki olasılığına karşı uyanık olmak ve bu hastaların yönetimine dikkat çekmekti.

Keywords

Antipsikotik ilaç , Antiepileptik ilaç , Nötropeni

Supporting Institution

yok

Project Number

yok

References

• 1. Bonilla MA. Disorders of white blood cells. In Manual of Pediatric Hematology and Oncology, Lanzkowsky ed, 5th edition, Amsterdam, Elsevier, 2011, p:272-320
• 2. Flanagan RJ, Dunk L. Haematological toxicity of drugs used in psychiatry. Hum Psychopharmacol Clin Exp. 2008; 23(1): 27-41
• 3. Uetrecht JP. Reactive metabolites and agranulocytosis. Eur J Haematol Suppl. 1996; 60: 83-88
• 4. Brouns R, De Deyn PP. Neurological complications in renal failure : a review. Clin Neurol Neurosurg. 2004; 107 (1): 1-16. doi: 10.1016/j.clineuro.2004.07.012.
• 5. Nair P, Lippmann S. Is leukopenia associated with divalproex and/or quetiapine? Can J Psychiatry. 2003; 48: 65-66
• 6. Bartels M, van Solinge WW, den Breeijen HJ, Bierings MB, Coffer PJ, Egberts TCG. Valproic acid treatment is associated with altered leukocyte subset development. J Clin Psychopharmacol. 2012; 32: 832–4
• 7. Rahman A, Mican LM, Fischer C, Campbell AH. Evaluating the incidence of leukopenia and neutropenia with valproate, quetiapine, or the combination in children and adolescents. Ann Pharmacother. 2009; 43: 822-830
• 8. Petrini M, Azzarà A. Lithium in the treatment of neutropenia. Curr Opin Hematol. 2012; 19(1): 52-7. doi: 10.1097/MOH.0b013e32834da93b
• 9. Yılmaz G, Erten E, Fıstıkcı N, Erek S, Saatcioglu O. Antipsikotik Kullanımıyla Tetiklenen Nötropeni Olgusunda Tedaviye Lityum Eklenmesi. Düşünen Adam The Journal of Psychiatry and Neurological Sciences. 2014; 27: 78-80 doi: 10.5350/DAJPN2014270111