Childhood Obesity with Resting State Functional Connectivity and Premature Pubarche with Neuroimaging Methods A Systematic Review

Abstract

Childhood obesity is a global health problem, the prevalence of which has rapidly increased in recent years, which is the result of the interaction between a complex set of factors and leads to serious medical consequences. rs-fMRI(resting-state functional magnetic resonance imaging) analysis techniques may be useful in elucidating the pathophysiology of obesity the progression of the disease and the changes in the brain functional structure caused by the disease state associated with high body mass index. Pubarche is a physiological condition that refers to the onset of hair growth in the pubic and axillary areas under the influence of sex hormones, which develops due to the increase in adrenal hormones. Childhood obesity causes early puberty and a significant portion of children with premature puberty are individuals with obesity. Studies on childhood obesity using different rs-fMRI analysis techniques were analyzed in detail in the literature to examine the contributions and innovations of these studies. In addition, premature pubarche has been systematically analyzed in studies using different neuroimaging methods. Due to the limited number of neuroimaging studies on premature pubarche and the lack of examination of its relationship with obesity and brain functionality, it presents itself as an issue that requires study.

Keywords

• Childhood obesity
• premature pubarche
• neuroimaging
• fMRI

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