Research Article
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Year 2020, Volume: 3 Issue: 1, 35 - 49, 29.03.2020

Abstract

References

  • Abbaspour N, Hurrell R, Kelishadi R (2014). Review on iron and its importance for human health. J Res Med Sci. 19(2): 164-174.
  • Agrawal R, Naveen Y (2011). Pharmaceutical processing–A review on wet granulation technology. International journal of pharmaceutical frontier research. 1(1): 65-83.
  • Allen LV, Popovich NG, Ansel HC (2011). Ansel's pharmaceutical dosage forms and drug delivery systems (9th ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins.
  • Altomare E, Vendemiale G, Benvenuti C, Andreatta P (1997). Bioavailability of a new effervescent tablet of ibuprofen in healthy volunteers. Eur J Clin Pharmacol. 52(6): 505-506.
  • Ashish P, Mishra P, Main P, Harsoliya MA, Agrawal S (2011). A review on-recent advancement in the development of rapid disintegrating tablet. Indian journal of life sciences and pharma research. 1(1): 7-16.
  • Aslani A, Fattahi F (2013). Formulation, characterization and physicochemical evaluation of potassium citrate effervescent tablets. Adv Pharm Bull. 3(1): 217-225.
  • Aslani A, Sharifian T (2014). Formulation, characterization and physicochemical evaluation of amoxicillin effervescent tablets. Advanced biomedical research. 3: 209.
  • Aulton ME, Taylor KM (2013). Aulton's Pharmaceutics: The Design and Manufacture of Medicines (4th ed.). London: Churchill Livingstone.
  • Boccio JR, Iyengar V (2003). Iron deficiency: causes, consequences, and strategies to overcome this nutritional problem. Biol Trace Elem Res. 94(1): 1-32.
  • Callahan J, Cleary G, Elefant M, Kaplan G, Kensler T, Nash R (1982). Equilibrium moisture content of pharmaceutical excipients. Drug Development and Industrial Pharmacy. 8(3): 355-369.
  • Conway BR (2008). Solid Dosage Forms. In S. C. Gad (Ed.), Pharmaceutical Manufacturing Handbook: Production and Processes (pp. 233-265). New York: John Wiley & Sons Inc.
  • Hadisoewignyo L, Soegianto L, Ervina M, Wijaya I, Santoso S, Tania N, Tjandrawinata RR (2016). Formulation Development and Optimization of Tablet Containing Combination of Salam (Syzygium Polyanthum) and Sambiloto (Andrographis paniculata) Ethanolic Extracts. International Journal of Pharmacy and Pharmaceutical Sciences. 8(3): 267-273.
  • Heinrich H (1974). Iron preparation and process for its manufacture. In: Google Patents.
  • Japanese Pharmacopoeia (2002). Ferrous Sulfate / Official Monographs for Part I. In Japanese Pharmacopoeia (14th ed., pp. 474).
  • Kasperek R, Zimmer L, Zun M, Dwornicka D, Wojciechowska K, Poleszak E (2016). The application of povidone in the preparation of modified release tablets. Current Issues in Pharmacy and Medical Sciences. 29(2): 71-78.
  • Lachman L, Lieberman HA, Kanig JL (1986). The theory and practice of industrial pharmacy (3rd ed.). Philadelphia: Lea & Febiger.
  • Moghimipour E, Akhgari A, Ghasemian Z (2010). Formulation of glucosamine effervescent granules.
  • Mohrle R (1989). Effervescent tablet. In Pharmaceutical dosage form: tablets, (2nd ed., Vol. 1, pp. 285-292)Liberman L, Lachman L, Schwartz JB (Eds.), New York: Marcel Dekker.
  • Ozyurt C, Evcin A(1994). P269 studies on formulations of foaming effervescent vaginal tablets. European Journal of Pharmaceutical Sciences. 2(1-2): 186.
  • Ozyurt C, Evcin A (1994). Studies on Formulations of Effervescent Vaginal Suppositories. Ankara Universitesi Eczacılık Fakultesi Dergisi. 23(1): 21-36.
  • Palanisamy P, Abhishekh R, Yogan and Kumar D (2011). Formulation and evaluation of effervescent tablets of aceclofenac. Int Res J Pharm. 2(12): 185-190.
  • Patel H, Chauhan P (2012). Formulation and Evaluation of Effervescent Tablet of Paracetamol and Ibuprofen. International Journal for Pharmaceutical Research Scholars. 1(2): 509-520.
  • Remington JP (2011). Remington: The Science and Practice of Pharmacy. In (pp. 895‑896): Pharmaceutical Press.
  • Rowe RC, Sheskey PJ, Quinn ME (2009). Handbook of Pharmaceutical Excipients (6th ed.). London: Pharmaceutical Press.
  • Saleh S, Boymond C, Stamm A (1988). Preparation of direct compressible effervescent components: spray-dried sodium bicarbonate. International journal of pharmaceutics. 45(1-2): 19-26.
  • Swarbrick J, Boylan J (2002). Encyclopedia of pharmaceutical technology. New York: Marcel Dekker.
  • Tolkien Z, Stecher L, Mander AP, Pereira DI, Powell JJ. (2015). Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis. PloS one. 10(2): e0117383.
  • USP26 (2002). The United States Pharmacopeia USP 26: The National Formulary NF 21. Rockville, MD: United States Pharmacopeial Convention.
  • USP31–NF26 (2008). Rockville MD USA: United States Pharmacopeial Convention.
  • WHO (2019). The International pharmacopoeia: Monographs: Dosage forms: General monographs: Tablets (9th ed.): Geneva: World Health Organization.
  • WHO (2019). The International pharmacopoeia: Monographs: Pharmaceutical substances: Ferrous sulfate. 9th. Retrieved from https://apps.who.int/phint/en/p/docf/anchor,finding-information.html
  • Yanze F, Duru C, Jacob M (2000). A process to produce effervescent tablets: fluidized bed dryer melt granulation. Drug Development and Industrial Pharmacy. 26(11): 1167-1176.

Development of effervescent tablet formulation which contain ferrous salt and ascorbic acid combination

Year 2020, Volume: 3 Issue: 1, 35 - 49, 29.03.2020

Abstract

This study aimed to develop the formulation of effervescent tablets containing ferrous sulfate and ascorbic acid combination to increase intestinal iron absorption and reduce gastrointestinal side effects related to iron supplementation.
In this study, the prototype formulation was calculated precisely and then prepared by three different methods for compression and evaluation. The flowability of powders and granules was investigated. Effervescent tablets were produced by direct compression and two different wet granulation methods. The produced tablets were then evaluated for acceptable hardness, friability <1 %, effervescence time <5 minutes, solution pH <6, water content <0.5 %, and optimum content uniformity.
The powder mixture prepared for the direct compression method had acceptable flowability but required a high compression force. Flowability and other physicochemical properties of this powder, including compressibility and hardness, were improved by granulation. The taste and color of the effervescent solution had good acceptability for the volunteers.
The results of the effervescent tablets produced by the GM2 method, which contain a higher percentage of granulated content were better than the other two methods. The PVP binder solution is suitable to produce effervescent granules that are compressed into tablets, due to improvements in flowability and compactibility.

References

  • Abbaspour N, Hurrell R, Kelishadi R (2014). Review on iron and its importance for human health. J Res Med Sci. 19(2): 164-174.
  • Agrawal R, Naveen Y (2011). Pharmaceutical processing–A review on wet granulation technology. International journal of pharmaceutical frontier research. 1(1): 65-83.
  • Allen LV, Popovich NG, Ansel HC (2011). Ansel's pharmaceutical dosage forms and drug delivery systems (9th ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins.
  • Altomare E, Vendemiale G, Benvenuti C, Andreatta P (1997). Bioavailability of a new effervescent tablet of ibuprofen in healthy volunteers. Eur J Clin Pharmacol. 52(6): 505-506.
  • Ashish P, Mishra P, Main P, Harsoliya MA, Agrawal S (2011). A review on-recent advancement in the development of rapid disintegrating tablet. Indian journal of life sciences and pharma research. 1(1): 7-16.
  • Aslani A, Fattahi F (2013). Formulation, characterization and physicochemical evaluation of potassium citrate effervescent tablets. Adv Pharm Bull. 3(1): 217-225.
  • Aslani A, Sharifian T (2014). Formulation, characterization and physicochemical evaluation of amoxicillin effervescent tablets. Advanced biomedical research. 3: 209.
  • Aulton ME, Taylor KM (2013). Aulton's Pharmaceutics: The Design and Manufacture of Medicines (4th ed.). London: Churchill Livingstone.
  • Boccio JR, Iyengar V (2003). Iron deficiency: causes, consequences, and strategies to overcome this nutritional problem. Biol Trace Elem Res. 94(1): 1-32.
  • Callahan J, Cleary G, Elefant M, Kaplan G, Kensler T, Nash R (1982). Equilibrium moisture content of pharmaceutical excipients. Drug Development and Industrial Pharmacy. 8(3): 355-369.
  • Conway BR (2008). Solid Dosage Forms. In S. C. Gad (Ed.), Pharmaceutical Manufacturing Handbook: Production and Processes (pp. 233-265). New York: John Wiley & Sons Inc.
  • Hadisoewignyo L, Soegianto L, Ervina M, Wijaya I, Santoso S, Tania N, Tjandrawinata RR (2016). Formulation Development and Optimization of Tablet Containing Combination of Salam (Syzygium Polyanthum) and Sambiloto (Andrographis paniculata) Ethanolic Extracts. International Journal of Pharmacy and Pharmaceutical Sciences. 8(3): 267-273.
  • Heinrich H (1974). Iron preparation and process for its manufacture. In: Google Patents.
  • Japanese Pharmacopoeia (2002). Ferrous Sulfate / Official Monographs for Part I. In Japanese Pharmacopoeia (14th ed., pp. 474).
  • Kasperek R, Zimmer L, Zun M, Dwornicka D, Wojciechowska K, Poleszak E (2016). The application of povidone in the preparation of modified release tablets. Current Issues in Pharmacy and Medical Sciences. 29(2): 71-78.
  • Lachman L, Lieberman HA, Kanig JL (1986). The theory and practice of industrial pharmacy (3rd ed.). Philadelphia: Lea & Febiger.
  • Moghimipour E, Akhgari A, Ghasemian Z (2010). Formulation of glucosamine effervescent granules.
  • Mohrle R (1989). Effervescent tablet. In Pharmaceutical dosage form: tablets, (2nd ed., Vol. 1, pp. 285-292)Liberman L, Lachman L, Schwartz JB (Eds.), New York: Marcel Dekker.
  • Ozyurt C, Evcin A(1994). P269 studies on formulations of foaming effervescent vaginal tablets. European Journal of Pharmaceutical Sciences. 2(1-2): 186.
  • Ozyurt C, Evcin A (1994). Studies on Formulations of Effervescent Vaginal Suppositories. Ankara Universitesi Eczacılık Fakultesi Dergisi. 23(1): 21-36.
  • Palanisamy P, Abhishekh R, Yogan and Kumar D (2011). Formulation and evaluation of effervescent tablets of aceclofenac. Int Res J Pharm. 2(12): 185-190.
  • Patel H, Chauhan P (2012). Formulation and Evaluation of Effervescent Tablet of Paracetamol and Ibuprofen. International Journal for Pharmaceutical Research Scholars. 1(2): 509-520.
  • Remington JP (2011). Remington: The Science and Practice of Pharmacy. In (pp. 895‑896): Pharmaceutical Press.
  • Rowe RC, Sheskey PJ, Quinn ME (2009). Handbook of Pharmaceutical Excipients (6th ed.). London: Pharmaceutical Press.
  • Saleh S, Boymond C, Stamm A (1988). Preparation of direct compressible effervescent components: spray-dried sodium bicarbonate. International journal of pharmaceutics. 45(1-2): 19-26.
  • Swarbrick J, Boylan J (2002). Encyclopedia of pharmaceutical technology. New York: Marcel Dekker.
  • Tolkien Z, Stecher L, Mander AP, Pereira DI, Powell JJ. (2015). Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis. PloS one. 10(2): e0117383.
  • USP26 (2002). The United States Pharmacopeia USP 26: The National Formulary NF 21. Rockville, MD: United States Pharmacopeial Convention.
  • USP31–NF26 (2008). Rockville MD USA: United States Pharmacopeial Convention.
  • WHO (2019). The International pharmacopoeia: Monographs: Dosage forms: General monographs: Tablets (9th ed.): Geneva: World Health Organization.
  • WHO (2019). The International pharmacopoeia: Monographs: Pharmaceutical substances: Ferrous sulfate. 9th. Retrieved from https://apps.who.int/phint/en/p/docf/anchor,finding-information.html
  • Yanze F, Duru C, Jacob M (2000). A process to produce effervescent tablets: fluidized bed dryer melt granulation. Drug Development and Industrial Pharmacy. 26(11): 1167-1176.
There are 32 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Research Article
Authors

Hasip Cem Ozyurt

Reza Mehrad

Publication Date March 29, 2020
Published in Issue Year 2020 Volume: 3 Issue: 1

Cite

APA Ozyurt, H. C., & Mehrad, R. (2020). Development of effervescent tablet formulation which contain ferrous salt and ascorbic acid combination. EMU Journal of Pharmaceutical Sciences, 3(1), 35-49.
AMA Ozyurt HC, Mehrad R. Development of effervescent tablet formulation which contain ferrous salt and ascorbic acid combination. EMUJPharmSci. March 2020;3(1):35-49.
Chicago Ozyurt, Hasip Cem, and Reza Mehrad. “Development of Effervescent Tablet Formulation Which Contain Ferrous Salt and Ascorbic Acid Combination”. EMU Journal of Pharmaceutical Sciences 3, no. 1 (March 2020): 35-49.
EndNote Ozyurt HC, Mehrad R (March 1, 2020) Development of effervescent tablet formulation which contain ferrous salt and ascorbic acid combination. EMU Journal of Pharmaceutical Sciences 3 1 35–49.
IEEE H. C. Ozyurt and R. Mehrad, “Development of effervescent tablet formulation which contain ferrous salt and ascorbic acid combination”, EMUJPharmSci, vol. 3, no. 1, pp. 35–49, 2020.
ISNAD Ozyurt, Hasip Cem - Mehrad, Reza. “Development of Effervescent Tablet Formulation Which Contain Ferrous Salt and Ascorbic Acid Combination”. EMU Journal of Pharmaceutical Sciences 3/1 (March 2020), 35-49.
JAMA Ozyurt HC, Mehrad R. Development of effervescent tablet formulation which contain ferrous salt and ascorbic acid combination. EMUJPharmSci. 2020;3:35–49.
MLA Ozyurt, Hasip Cem and Reza Mehrad. “Development of Effervescent Tablet Formulation Which Contain Ferrous Salt and Ascorbic Acid Combination”. EMU Journal of Pharmaceutical Sciences, vol. 3, no. 1, 2020, pp. 35-49.
Vancouver Ozyurt HC, Mehrad R. Development of effervescent tablet formulation which contain ferrous salt and ascorbic acid combination. EMUJPharmSci. 2020;3(1):35-49.