Comparison of clinical, endoscopic, and histological features of patients diagnosed with alkaline reflux gastritis before and after ursodeoxycholic acid treatment

Year 2017, , 53 - 56, 23.11.2017

Halil Rakıcı

https://doi.org/10.17940/endoskopi.339843

Abstract

Abstract: Bacground and Aims. Alkaline reflux gastritis is
characterized by non-acidic flow from the duodenum to the stomach. It is seen
very commonly among operated patients. It can also be seen among non-operated
patients, due to a defect in duodenogastric antireflux mechanisms. Various medications
are used for its treatment. We aimed to analyze the clinical, endoscopic, and
histological effects of ursodeoxycholic acid in non-operated patients in this
study. Material and Methods. A total of 72 patients who were diagnosed with
alkaline reflux gastritis as a result of endoscopic imagining were treated with
ursodeoxycholic acid. Clinical, endoscopic, and histological features were analyzed
after 2 months of treatment. A total of 72 patients were analyzed clinically, and
61 patients who had control endoscopy were analyzed endoscopically and
histologically. Results. Of the
total, 38 patients were female and 34 were male. The youngest and oldest patients
were 19 and 81 years of age, respectively. The average age was 50 years. After treatment,
54 patients out of 72 reported benefits. Sixteen patients out of 61 who had
control endoscopy were diagnosed endoscopically with alkaline reflux gastritis.
Normal mucosa was observed instead of chronic gastritis and inflammation in 6
out of 61 patients who had control histological examination. Conclusion. In all, 75% of the patients who were
treated with ursodeoxycholic acid recovered clinically. Altogether, 73.7% of patients
recovered endoscopically. Only 9.9% of patients recovered histologically. In
conclusion, ursodeoxycholic acid treatment is effective clinically and
endoscopically but is ineffective histologically.

Keywords

alkaline reflux, gastritis, ursodeoxycholic acid

Alkalen reflü gastrit tanısı ile ursodeoksikolik asit tedavisi almış hastaların tedavi öncesi ve sonrası klinik, endoskopik ve histolojik bulgularının değerlendirilmesi

Abstract

Giriş ve Amaç: Alkalen reflü gastrit asidik olmayan
safranın mide içine reflüsüne verilen isimdir. Opere midede sık görülmekle
birlikte cerrahi girişim geçirmeyen hastalarda da duodenogastrik antifeflü
mekanizmalardaki bozukluk sonucunda ortaya çıkmaktadır. Medikal tedavisinde
çeşitli ilaçlar kullanılmaktadır. Biz bu çalışmada cerrahi girişim geçirmemiş
hastalarda ursodeoksikolik asitin klinik, endoskopik ve histolojik etkilerini
incelemeyi amaçladık. Gereç ve Yöntem: Endoskopik inceleme sonucu alkalen reflü gastrit saptanan 72 hastaya
ursodeoksikolik asit tedavisi verildi. İki aylık tedavi sonunda klinik,
endoskopik ve histolojik bulgular değerlendirildi. Klinik değerlendirme 72
hastada, endoskopik ve histolojik değerlendirme ise kontrol endoskopi yaptıran
61 hasta üzerinden yapıldı. Bulgular: Hastaların 38’i (%52.7) kadın, 34’ü (%47.3) erkekti. En küçük yaş 19, en
büyük yaş 81 olup, ortalama yaş 50 idi. Tedavi sonrası 72 hastanın 54’ü (%75)
tedaviden fayda gördüğünü bildirdi. Kontrol endoskopi yapılan 61 hastanın
45’inde (%73.7) endoskopik tanı alkalen reflü gastrit olarak bildirilmedi.
Kontrol histolojik inceleme yapılan 61 hastanın 6’sında (%9.9) kronik gastrit
ve inflamasyon yerine normal mukoza saptandı. Sonuç: Ursodeoksikolik asit tedavisi verilen hastaların %75’inin
klinik olarak tedaviden fayda gördüğü saptandı. Endoskopik olarak tedavi
sonrası hastaların %73.7’sinde alkalen reflü gastrit saptanmadı. Histolojik
olarak hastaların ancak %9.9’unda histolojik bulguların düzeldiği görüldü. Bu
bulgularla alkali reflü gastrit tedaviside ursodeoksikolik asitin klinik ve
endoskopik bulguların düzelmesinde etkili, histolojik bulguları düzeltmede ise
etkisiz olduğunu söylemek mümkündür.

Keywords

Alkalen reflü, gastrit, ursodeoksikolik asit

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