Drug-induced esophagitis: Incidence, clinical and endoscopic findings, and management

Year 2019, , 1 - 6, 15.04.2019

Ahmet Uyanıkoğlu

https://doi.org/10.17940/endoskopi.566273

Abstract

Background and Aims: Drug-induced esophagitis is a rare condition,
which presents with varying severity in terms of clinical and gastroscopic
findings. This study aimed to investigate the incidence, clinical and
endoscopic findings, and management of the disease in a prospective 1-year
follow-up period. Materials and Methods:
Overall, 4185 patients underwent esophagogastroduodenoscopy at the Endoscopy
Unit of Erzurum Education and Research Hospital between February 2010 and February
2011. Among these, the patients diagnosed with drug-induced esophagitis were
followed up prospectively. Results:
Among patients who underwent esophagogastroduodenoscopy, 1926 (46%) were males with
a mean age of 47.8±18.1 years (range, 12–100 years). In total, 760 patients (18%)
were diagnosed with esophagitis, of which five had drug-induced esophagitis (0.012%
of gastroscopies, 0.65% of esophagitis). All patients presented with symptoms of
retrosternal pain, odynophagia, and dysphagia. Four patients were young women, whereas
the remaining patient was an elderly man; based on the medical history and esophagogastroduodenoscopy
findings, patients diagnosed with esophagitis were using doxycycline,
tetracycline, and tramadol hydrochloride capsules. Drugs that were considered to
be the causative agents of esophagitis were discontinued, and proton pump
inhibitors were administered parenterally or orally. The patients recovered
without any complications. Conclusion:
Drug-induced esophagitis is considered to be a rare condition, presenting with varying
esophagogastroduodenoscopy findings and severe esophagitis in some cases. Discontinuing
the causative agent and administering proton pump inhibitors are sufficient to
manage the condition.

Keywords

Drug-induced esophagitis, incidence, treatment

İlaca bağlı özofajit: İnsidans, klinik ve endokospik bulgular ve yönetimi

Abstract

Giriş ve Amaç: İlaca bağlı özofajit nadir görülen bir
antite olup, değişik derecede klinik ve özofagogastroduodonoskopik bulgularla
prezente olur. Bir yıllık periodda görülme sıklığı, klinik ve gastroskopik özelliklerin
incelenmesi amaçlanmıştır. Gereç ve
Yöntem: Şubat 2010-Şubat 2011 yılları arasında Erzurum Eğitim ve Araştırma
Hastanesinde gastroskopisi yapılan 4185 hastada, ilaca bağlı özofajit saptanan
hastalar prospektif olarak takip edildi. Bulgular:
Özofagogastroduodonoskopik yapılan hastaların 
yaş ortalamsı 47.8±18.1 (dağılım 12-100) yaş olup, 1926 (%46)’sı
erkekti. Hastaların 760 tanesinde (%18) özofajit saptandı. Hastaların 5
tanesinde (özofagogastroduodonoskopik yapılanların %0.012’si, özofajitlerin
%0.65’i) ilaca bağlı özofajit tesbit edildi. Tüm hastaların retrosternal ağrı,
disfaji ve odinofaji yakınmaları vardı. Bu hastaların 4 tanesi genç kadın, 1
tanesi yaşlı erkek olup, hastalara doksisiklin, tetrasiklin ve tramodol hidroklorür
alım hikayeleri ve gastroskopi bulguları ile tanı konuldu. Tanı konulduktan
sonra sebeb olan ilaçlar kesilerek, enteral veya parenteral proton pompa
inhibitörü başlandı. Takiplerde hiçbir hastada komplikasyon gelişmedi. Sonuç: İlaca bağlı özofajit sık görülen
biri klinik antite olmayıp, hastalar değişik derecelerde özofagogastroduodonoskopik
bulgularla, bazen ciddi özofajitle prezente olur. Sebep olan ilacın kesilmesi
ve proton pompa inhibitörü tedavisi yeterli olmaktadır.

Keywords

İlaca bağlı özofajit, insidans, tedavi

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