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The evaluation of serum folate and B12 levels as markers of liver metastases in stomach and colon cancer

Yıl 2014, , 25 - 28, 01.08.2014

Veli Çakıcı Elif Yorulmaz Hasan Hüseyin Mutlu Celal Ulaşoğlu Mehmet Çelik İlyas Tuncer Hilmi Çiftci Gözde Derviş Hakim Hacer Hicran Beyca Ebubekir Şenateş

https://doi.org/10.17940/endoskopi.74778

Öz

Background and Aims:Vitamin B12 and folate are two important vitamins necessary for cell division, proliferation and DNA synthesis. In this study, we aimed to evaluate the levels of B12 and folate as indicators of liver metastases of stomach and colon cancer. Materials and Methods: The study group consisted of 31 patients with colon cancer, 30 patients with gastric cancer and 30 healthy control subjects. Presence of liver metastases was evaluated by computerized tomography. Patients with or without liver metastases were compared with the control group in terms of vitamin B12 and folate levels. Results: Twelve (40%) patients with gastric cancer and 8 (25.8%) patients with colon cancer had liver metastases. Folate levels were significantly lower (p

Anahtar Kelimeler

Folate colon cancer gastric cancer vitamin B12

Kaynakça

  • Miller SM, Mears M. Nutritional Status Assessment. In: Anderson SC, Cockayne S (eds). Clinical Chemistry Concept and Applications. New York: Mc Graw Hill; 2003:579-611.
  • Dahlin A, Guelpen B, Hultdin J, et al. Plasma vitamin B12 concentra- tions and risk of colorectal cancer: a nested case-referent study. Int J Cancer 2008;122:2057-61.
  • Duthie SJ, Narayanan S, Sharp L, et al. Folate DNA stability and colo- rectal neoplasia. Proc Nutr Soc 2004;63:571-8.
  • Ermens A, Vlasveld L, Lindemans J. Significance of elevated cobalamin (vitamin B12) levels in blood. Clin Biochem 2003;36:585-90.
  • Boisson F, FremontS, Migeon C, et al. Human haptocorrin in hepatocel- lular carcinoma. Cancer Detect Prev 1999;23:89-96.
  • Hubner RA, Houlston RS. Folate and colorectal cancer prevention. Br J Cancer 2009;100:233-9.
  • Weng YR, Sun DF, Fang JY, et al. Folate levels in mocosal tissue but not methylenetetrahydrofolate reductase polymorphisms are associated with gastric carcinogenesis. World J Gastroenterol 2006;12:7591-7.
  • Giovannucci E. Epidemiological studies of folate and colorectal neopla- sia. J Nutr 2002;132:2350S-5S.
  • Kim YI. Folate and carcinogenesis: evidence, mechanisms and implica- tions. J Nutr Biochem. 1999;10:66-88.
  • Alonso E, Gonzales MP, Poo R, Varela G. Folate status and S-adeno- sylmethionine/ S-adenosylhomocysteine ratio in colorectal adenocarci- noma in humans. J Clin Nutr 2008:62;295-8.
  • Giovannucci E, Stampfer MJ, Colditz GA, et al. Multivitamin use, folat and colon cancer in women in the Nurses Health Study. Ann Intern Med 1998;129:517-24.
  • Freudenheim JL, Saxon G, Marshall JR, et al. Folate intake and carcino- genesis of the colon and rectum. Int J Epidemiol 1991;20:368-74.
  • Gimsing P, Hippe E. Increased concentration of transcobalamin I in a patient with metastatic carcinoma of the breast. Scand J Haematol 1978;21:243-9.
  • Carmel R. Extreme elevation of serum transcobalamin I in a patient with metastatic cancer. N Engl J Med 1975;292:282-4.
  • Carmel R, Eisenberg L. Serum vitamin B12 and transcobalamin abnor- malities in patients with cancer. J Cancer 1977;40:1348-53.
  • Wakatsuki Y, İnada M, Kudo H, et al. Immunological characterization and clinical implication of cobalamin binding protein in human gastric cancer. Cancer Res 1983;49:3122-8.
  • Gürdal E, Karadağ M, Özyardımcı N, ve ark. Cigarette smoking, serum lipids, folate and vitamin B12 in lung cancer. J Environ Pathol Toxicol Oncol 1996;15:161-7.
  • Johan H, Guelpen B, Bergh A, et al. Plasma folate, vitamin B12, and homocystein and prostate cancer risk: a prospective study. Int J Cancer 2005;113:819-24.
  • Geissbühler P, Mermillod B, Rapin CH. Elevated serum vitamin B12 lev- els associated with CRP as a predictive factor of mortality in palliative care cancer patients; a prospective study over five years. J Pain Symptom Manage 2000;20:93-103.
  • Salles N, Hermann F, Sıeber C, Rapin C. High vitamin B12 and mortality in elderly inpatients. Journal of Nutrition. 2008;12:219-21
  • Kane SP, Murray IM, Paradinas FJ, et al. Vitamin B12 binding protein as a tumor marker for HCC. Gut 1978;19:1105-9.
  • Wheeler K, Pritchard J, Luck W, Rossiter M. Transcobalamin I as a marker for fibrolamellar hepatoma. Med Ped Oncol 1986;14:227-9.
  • Karpeh MS, Kelsen DP, Tepper JE. Cancer of the stomach. DeVita VT Jr, Hellman S, Rosenberg SA (eds). Cancer principles &pPractice of oncol- ogy. Lippincott Williams & Wilkins, 6th ed. Philadelphia; 2001:1092- 126.
  • Lavery IC, López-Kostner F, Pelley RJ, Fine RM. Treatment of colon and rectal cancer. Surg Clin North Am 2000;80:535-69.

Mide ve kolon kanserlerinde metastaz göstergesi olarak serum folat ve vitamin B12 düzeylerininirdelenmesi

Yıl 2014, , 25 - 28, 01.08.2014

Veli Çakıcı Elif Yorulmaz Hasan Hüseyin Mutlu Celal Ulaşoğlu Mehmet Çelik İlyas Tuncer Hilmi Çiftci Gözde Derviş Hakim Hacer Hicran Beyca Ebubekir Şenateş

https://doi.org/10.17940/endoskopi.74778

Öz

Giriş ve Amaç:Vitamin B12 ve folat hücre bölünmesi ve çoğalması için gerekli olan DNA yapımında yer alan iki önemli vitamindir. Bu çalışmada vitamin B12 ve folat düzeylerinin mide ve kolon kanserinde karaciğer metastazı göstergesi olarak değerlendirilmesi amaçlandı. Gereç ve Yöntem: Çalışmaya 30 mide kanserli ve 30 kolon kanserli hasta ile kontrol grubu olarak 30 sağlıklı kişi alındı. Hastaların karaciğer metastazları bilgisayarlı tomografi ile değerlendirildi. Metastatik olan ve olmayan gruplar vitamin B12 ve folat düzeyleri açısından karşılaştırıldı. Bulgular: Mide kanserli hastaların 12'sinde (%40), kolon kanserli hastaların 8'inde (%25.8) karaciğer metastazı saptandı. Folat değerleri, kanserli grupta kontrol grubuna göre anlamlı derecede düşük bulunurken (p

Anahtar Kelimeler

Folat kolon kanseri mide kanseri vitamin B12

Kaynakça

  • Miller SM, Mears M. Nutritional Status Assessment. In: Anderson SC, Cockayne S (eds). Clinical Chemistry Concept and Applications. New York: Mc Graw Hill; 2003:579-611.
  • Dahlin A, Guelpen B, Hultdin J, et al. Plasma vitamin B12 concentra- tions and risk of colorectal cancer: a nested case-referent study. Int J Cancer 2008;122:2057-61.
  • Duthie SJ, Narayanan S, Sharp L, et al. Folate DNA stability and colo- rectal neoplasia. Proc Nutr Soc 2004;63:571-8.
  • Ermens A, Vlasveld L, Lindemans J. Significance of elevated cobalamin (vitamin B12) levels in blood. Clin Biochem 2003;36:585-90.
  • Boisson F, FremontS, Migeon C, et al. Human haptocorrin in hepatocel- lular carcinoma. Cancer Detect Prev 1999;23:89-96.
  • Hubner RA, Houlston RS. Folate and colorectal cancer prevention. Br J Cancer 2009;100:233-9.
  • Weng YR, Sun DF, Fang JY, et al. Folate levels in mocosal tissue but not methylenetetrahydrofolate reductase polymorphisms are associated with gastric carcinogenesis. World J Gastroenterol 2006;12:7591-7.
  • Giovannucci E. Epidemiological studies of folate and colorectal neopla- sia. J Nutr 2002;132:2350S-5S.
  • Kim YI. Folate and carcinogenesis: evidence, mechanisms and implica- tions. J Nutr Biochem. 1999;10:66-88.
  • Alonso E, Gonzales MP, Poo R, Varela G. Folate status and S-adeno- sylmethionine/ S-adenosylhomocysteine ratio in colorectal adenocarci- noma in humans. J Clin Nutr 2008:62;295-8.
  • Giovannucci E, Stampfer MJ, Colditz GA, et al. Multivitamin use, folat and colon cancer in women in the Nurses Health Study. Ann Intern Med 1998;129:517-24.
  • Freudenheim JL, Saxon G, Marshall JR, et al. Folate intake and carcino- genesis of the colon and rectum. Int J Epidemiol 1991;20:368-74.
  • Gimsing P, Hippe E. Increased concentration of transcobalamin I in a patient with metastatic carcinoma of the breast. Scand J Haematol 1978;21:243-9.
  • Carmel R. Extreme elevation of serum transcobalamin I in a patient with metastatic cancer. N Engl J Med 1975;292:282-4.
  • Carmel R, Eisenberg L. Serum vitamin B12 and transcobalamin abnor- malities in patients with cancer. J Cancer 1977;40:1348-53.
  • Wakatsuki Y, İnada M, Kudo H, et al. Immunological characterization and clinical implication of cobalamin binding protein in human gastric cancer. Cancer Res 1983;49:3122-8.
  • Gürdal E, Karadağ M, Özyardımcı N, ve ark. Cigarette smoking, serum lipids, folate and vitamin B12 in lung cancer. J Environ Pathol Toxicol Oncol 1996;15:161-7.
  • Johan H, Guelpen B, Bergh A, et al. Plasma folate, vitamin B12, and homocystein and prostate cancer risk: a prospective study. Int J Cancer 2005;113:819-24.
  • Geissbühler P, Mermillod B, Rapin CH. Elevated serum vitamin B12 lev- els associated with CRP as a predictive factor of mortality in palliative care cancer patients; a prospective study over five years. J Pain Symptom Manage 2000;20:93-103.
  • Salles N, Hermann F, Sıeber C, Rapin C. High vitamin B12 and mortality in elderly inpatients. Journal of Nutrition. 2008;12:219-21
  • Kane SP, Murray IM, Paradinas FJ, et al. Vitamin B12 binding protein as a tumor marker for HCC. Gut 1978;19:1105-9.
  • Wheeler K, Pritchard J, Luck W, Rossiter M. Transcobalamin I as a marker for fibrolamellar hepatoma. Med Ped Oncol 1986;14:227-9.
  • Karpeh MS, Kelsen DP, Tepper JE. Cancer of the stomach. DeVita VT Jr, Hellman S, Rosenberg SA (eds). Cancer principles &pPractice of oncol- ogy. Lippincott Williams & Wilkins, 6th ed. Philadelphia; 2001:1092- 126.
  • Lavery IC, López-Kostner F, Pelley RJ, Fine RM. Treatment of colon and rectal cancer. Surg Clin North Am 2000;80:535-69.
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Veli Çakıcı Bu kişi benim

Elif Yorulmaz Bu kişi benim

Hasan Hüseyin Mutlu Bu kişi benim

Celal Ulaşoğlu Bu kişi benim

Mehmet Çelik Bu kişi benim

İlyas Tuncer Bu kişi benim

Hilmi Çiftci Bu kişi benim

Gözde Derviş Hakim Bu kişi benim

Hacer Hicran Beyca Bu kişi benim

Ebubekir Şenateş Bu kişi benim

Yayımlanma Tarihi 1 Ağustos 2014
Yayımlandığı Sayı Yıl 2014

Kaynak Göster

APA Çakıcı, V., Yorulmaz, E., Mutlu, H. H., Ulaşoğlu, C., vd. (2014). Mide ve kolon kanserlerinde metastaz göstergesi olarak serum folat ve vitamin B12 düzeylerininirdelenmesi. Endoskopi Gastrointestinal, 22(2), 25-28. https://doi.org/10.17940/endoskopi.74778
AMA Çakıcı V, Yorulmaz E, Mutlu HH, Ulaşoğlu C, Çelik M, Tuncer İ, Çiftci H, Hakim GD, Beyca HH, Şenateş E. Mide ve kolon kanserlerinde metastaz göstergesi olarak serum folat ve vitamin B12 düzeylerininirdelenmesi. Endoskopi Gastrointestinal. Ağustos 2014;22(2):25-28. doi:10.17940/endoskopi.74778
Chicago Çakıcı, Veli, Elif Yorulmaz, Hasan Hüseyin Mutlu, Celal Ulaşoğlu, Mehmet Çelik, İlyas Tuncer, Hilmi Çiftci, Gözde Derviş Hakim, Hacer Hicran Beyca, ve Ebubekir Şenateş. “Mide Ve Kolon Kanserlerinde Metastaz göstergesi Olarak Serum Folat Ve Vitamin B12 düzeylerininirdelenmesi”. Endoskopi Gastrointestinal 22, sy. 2 (Ağustos 2014): 25-28. https://doi.org/10.17940/endoskopi.74778.
EndNote Çakıcı V, Yorulmaz E, Mutlu HH, Ulaşoğlu C, Çelik M, Tuncer İ, Çiftci H, Hakim GD, Beyca HH, Şenateş E (01 Ağustos 2014) Mide ve kolon kanserlerinde metastaz göstergesi olarak serum folat ve vitamin B12 düzeylerininirdelenmesi. Endoskopi Gastrointestinal 22 2 25–28.
IEEE V. Çakıcı, “Mide ve kolon kanserlerinde metastaz göstergesi olarak serum folat ve vitamin B12 düzeylerininirdelenmesi”, Endoskopi Gastrointestinal, c. 22, sy. 2, ss. 25–28, 2014, doi: 10.17940/endoskopi.74778.
ISNAD Çakıcı, Veli vd. “Mide Ve Kolon Kanserlerinde Metastaz göstergesi Olarak Serum Folat Ve Vitamin B12 düzeylerininirdelenmesi”. Endoskopi Gastrointestinal 22/2 (Ağustos 2014), 25-28. https://doi.org/10.17940/endoskopi.74778.
JAMA Çakıcı V, Yorulmaz E, Mutlu HH, Ulaşoğlu C, Çelik M, Tuncer İ, Çiftci H, Hakim GD, Beyca HH, Şenateş E. Mide ve kolon kanserlerinde metastaz göstergesi olarak serum folat ve vitamin B12 düzeylerininirdelenmesi. Endoskopi Gastrointestinal. 2014;22:25–28.
MLA Çakıcı, Veli vd. “Mide Ve Kolon Kanserlerinde Metastaz göstergesi Olarak Serum Folat Ve Vitamin B12 düzeylerininirdelenmesi”. Endoskopi Gastrointestinal, c. 22, sy. 2, 2014, ss. 25-28, doi:10.17940/endoskopi.74778.
Vancouver Çakıcı V, Yorulmaz E, Mutlu HH, Ulaşoğlu C, Çelik M, Tuncer İ, Çiftci H, Hakim GD, Beyca HH, Şenateş E. Mide ve kolon kanserlerinde metastaz göstergesi olarak serum folat ve vitamin B12 düzeylerininirdelenmesi. Endoskopi Gastrointestinal. 2014;22(2):25-8.