The clinical effect of Helicobacter pylorieradication with sequential therapy in patients with peptic ulcer or functional dyspepsia

Year 2013, , - , 01.12.2013

Murat Sarıkaya Nesibe Taşer Bilal Ergül Zeynal Doğan Levent Filik

https://doi.org/10.17940/endoskopi.74794

Abstract

Background and Aims: Helicobacter pylori infection plays an important role in the etiology of peptic ulcer and functional dyspepsia. Patients with peptic ulcer benefit from eradication of Helicobacter pylori, but there are fewer data related to this favorable response in patients with functional dyspepsia. In this study, we aimed to compare the benefit of sequential eradication therapy in patients with ulcer and non-ulcer dyspepsia who were diagnosed with Helicobacter pylori infection. Materials and Methods:166 patients were included in this study. Helicobacter pylori was checked via gastroscopic biopsy and rapid urease test. In all patients, the eradication status was checked by urea breath test in the 12 th week. Gastrointestinal symptom rating scale score was used to determine symptomatic improvement. Results:In the groups of ulcer and functional dyspepsia, a significant difference was determined in gastrointestinal symptom rating scale scores with sequential therapy (p

Keywords

Helicobacter pylori, sequential therapy, functional dyspepsia, peptic ulcer

Peptik ülser ve fonksiyonel dispepside ardışık tedavi ile yapılan Helicobacter pylorieradikasyonunun klinik etkisi

Abstract

Giriş ve Amaç:Helicobacter pylori enfeksiyonu peptik ülser ve fonksiyonel dispepsi etiyolojisinde önemli rol oynamaktadır. Helicobacter pylori eradikasyonu peptik ülserli hastalarda büyük fayda sağlamasına karşın fonksiyonel dispepsili hastalarda bu yarar üzerine daha az sayıda veriler bulunmaktadır. Bu çalışmada Helicobacter pylori enfeksiyonu saptanan ülserli ve nonülser dispepsili hastalarda ardışık eradikasyon tedavisinin yararını kar-şılaştırmayı amaçladık. Gereç ve Yöntem:Çalışmaya total 166 hasta dahil edildi. Hastalarda Helicobacter pylori pozitifliği gastroskopik biyopsi ve hızlı üreaz testi ile tespit edildi. Tüm hastalarda 12. haftada eradikasyon durumu üre nefes testi ile kontrol edildi. Semptomatik düzelme için Gastrointestinal Semptom Değerlendirme Skalası kullanıldı. Bulgular: Ülser ve fonksiyonel dispepsi gruplarının her ikisinde de ardışık tedavi ile Gastrointestinal Semptom Değerlendirme Skalası skorlarında anlamlı farklılık saptandı (p

Keywords

Helicobacter pylori, ardışık eradikasyon tedavisi, fonksiyonel dispepsi, peptik ülser

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