The contribution of upper gastrointestinal system pathology to iron deficiency anemia in an adult population over 60 years of age
Abstract
Background and Aims:In an elderly patient population, we aimed to define the contribution of upper gastrointestinal system pathology (malignancies, high-risk precancerous lesions, Helicobacter pylori) to iron deficiency anemia. Materials and Methods:A retrospective cohort study was designed to define the contribution of upper gastrointestinal system pathology to iron deficiency anemia. Electronic hospital records formed of standard medical terminology constituted the basis of data extraction. Based on the exclusion criteria, only patients with possible upper gastrointestinal system pathology were evaluated. Results:In 39 patients, H. pylori-related pathology was found, whereas 41 patients had presented with a high-risk lesion of the stomach. Three patients were found to have gastric cancer and 1 patient had been diagnosed with Celiac disease. Age and ferritin levels were lower in patients with H. pylori positivity. Conclusions:In this elderly patient population, the contribution of upper gastrointestinal system pathology (high-risk lesions, overt malignancy, H. pylori association) to iron deficiency anemia is important, and H. pylori is a treatable cause of iron deficiency anemia.
Keywords
Iron deficiency anemia endoscopic screening gastric carcinoma atrophic gastritis intestinal metaplasia dysplasia geriatricpatients
References
- Mast AE, Blinder MA, Gronowski AM, et al. Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several popu- lations. Clin Chem 1998;44:45-51.
- Goddard AF, James MW, McIntyre AS, et al. Guidelines for the manage- ment of iron deficiency anaemia. Gut 2011;60:1309-16.
- Malfertheiner P, Megraud F, O’Morain CA, et al. Management of Helico- bacter pylori infection--the Maastricht IV/ Florence Consensus Report. Gut 2012;61:646-64.
- Hamaker ME, Acampo T, Remijn JA, et al. Diagnostic choices and clini- cal outcomes in octogenarians and nonagenarians with iron-deficiency anemia in the Netherlands. J Am Geriatr Soc 2013;61:495-501.
- Droogendijk J, Beukers R, Berendes PB, et al. Screening for gastrointesti- nal malignancy in patients with iron deficiency anemia by general practi- tioners: an observational study. Scand J Gastroenterol 2011;46:1105-10.
- Damery S, Ryan R, Wilson S, et al. Iron deficiency anaemia and delayed diagnosis of colorectal cancer: a retrospective cohort study. Colorectal Dis 2011;13:e53-60.
- Madej D, Borowska K, Bylinowska J, et al. Dietary intakes of iron and zinc assessed in a selected group of the elderly: are they adequate? Rocz Panstw Zakl Hig 2013;64:97-104.
- Baicus C, Caraiola S, Rimbas M, et al. Ferritin above 100 mcg/L could rule out colon cancer, but not gastric or rectal cancer in patients with involuntary weight loss. BMC Gastroenterol 2012;12:86.
Altmış yaş üstü erişkin hastalarda demir eksikliği anemisi nedeni olarak yalnız başına üst gastrointestinal sistem patolojilerinin katkısının araştırılması
Abstract
Giriş ve Amaç: Demir eksikliği olan yaşlı popülasyonda üst gastrointestinal sistemin yalnız başına katkısını ve Helicobacter pylori ile olan ilişkinin belirlenmesi. Gereç ve Yöntem:Retrospektif kesitsel kohort düzeninde elektronik tıbbi kayıtların taranması ile demir eksikliği anemisi ile ilişkili diğer risk faktörlerinin elendiği ve alt gastrointestinal sistem taramalarının normal olduğu hastalar seçilmiştir. Bulgular:60 yaş üzerindeki yaşlı popülasyonda histopatolojik olarak 39 hastada Helicobacter pylori pozitifliği saptandı. Ayrıca mideden elde edilen biyopsilerde 41 hastada prekanseröz lezyon ve 3 hastada da mide kanseri saptandı. Özofagus ve duodenum incelemesinde 1 hastada Çölyak hastalığı saptandı. Helicobacter pylori pozitif olan hastalarda olmayanlara göre hemoglobin seviyesinde farklılık saptanmadı ancak pozitif gruptaki hastaların daha genç ve daha çok ferritin düşüklüğü olduğu bulundu. Sonuç:Yaşlı hasta grubunda demir eksikliği anemisinde diğer etkenler normal olsa bile üst gastrointestinal taranması yüksek riskli lezyonlar, malignite ve Helicobacter pylori ile olan ilişkisi nedeni ile gereklidir.
Keywords
Demir eksikliği anemisi endoskopik tarama mide kanseri atrofik gastrik intestinal metaplazi displazi geriatrik hasta
References
- Mast AE, Blinder MA, Gronowski AM, et al. Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several popu- lations. Clin Chem 1998;44:45-51.
- Goddard AF, James MW, McIntyre AS, et al. Guidelines for the manage- ment of iron deficiency anaemia. Gut 2011;60:1309-16.
- Malfertheiner P, Megraud F, O’Morain CA, et al. Management of Helico- bacter pylori infection--the Maastricht IV/ Florence Consensus Report. Gut 2012;61:646-64.
- Hamaker ME, Acampo T, Remijn JA, et al. Diagnostic choices and clini- cal outcomes in octogenarians and nonagenarians with iron-deficiency anemia in the Netherlands. J Am Geriatr Soc 2013;61:495-501.
- Droogendijk J, Beukers R, Berendes PB, et al. Screening for gastrointesti- nal malignancy in patients with iron deficiency anemia by general practi- tioners: an observational study. Scand J Gastroenterol 2011;46:1105-10.
- Damery S, Ryan R, Wilson S, et al. Iron deficiency anaemia and delayed diagnosis of colorectal cancer: a retrospective cohort study. Colorectal Dis 2011;13:e53-60.
- Madej D, Borowska K, Bylinowska J, et al. Dietary intakes of iron and zinc assessed in a selected group of the elderly: are they adequate? Rocz Panstw Zakl Hig 2013;64:97-104.
- Baicus C, Caraiola S, Rimbas M, et al. Ferritin above 100 mcg/L could rule out colon cancer, but not gastric or rectal cancer in patients with involuntary weight loss. BMC Gastroenterol 2012;12:86.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | December 1, 2013 |
| Published in Issue | Year 2013 |