Adjuvant chemoradiotherapy in patients with gastric cancer: Single-center experience

Year 2012, , 8 - 12, 01.04.2012

Birsen Yücel Ebru Atasever Akkaş Yıllar Okur Nalan Babacan Mehmet Fuat Eren Turgut Kaçan Saadettin Kılıçkap

https://doi.org/10.17940/endoskopi.74840

Abstract

Background/aims: The purpose of this study was to review survival analysis, side effects and prognostic factors in patients with gastric cancer who were treated with adjuvant chemoradiotherapy. Materials and Methods: In this study, we retrospectively evaluated the data of 90 patients with gastric cancer followed at Cumhuriyet University Faculty of Medicine, Oncology Center. Results: This study analyzed the data of 90 patients (68 (76%) males, 22 (24%) females). The median follow-up was 19 months (range: 4-105). The two-year overall and disease-free survival rates were 62% and 58%, respectively. In univariate analysis, the factors that determined survival were grade (p: 0.039), T (p: 0.001) and N (p: 0.020) stages, weight loss (p: 0.001), Eastern Cooperative Oncology Group performance status (p: 0.002), anemia (p: 0.019), and hypoalbuminemia (p: 0.001). After multivariate analysis, weight loss (p: 0.008), T stage (p: 0.024) and Eastern Cooperative Oncology Group performance status (p: 0.033) were determined as indepenent prognostic factors that affect survival. The most frequent side effects were nausea and vomiting in 66 patients (73%), dyspepsia in 52 patients (58%), anemia in 45 patients (50%), neutropenia in 36 patients (40%), diarrhea in 34 patients (38%), and weight loss in 29 patients (32%). Conclusions: It was shown that the overall survival and disease-free survival in non-metastatic gastric cancer patients who received adjuvant chemoradiotherapy complied with the literature.

Keywords

Gastric cancer, chemoradiotherapy, survival, prognosis

Mide kanserli hastalarda adjuvan kemoradyoterapi: Tek merkez deneyimi

Abstract

Giriş ve Amaç: Bu çalışmada, adjuvan kemoradyoterapi ile tedavi edilen mide kanserli hastaların sağkalım analizi, tedavi yan etkileri ve sağkalımı etkileyen prognostik faktörlerin incelemesi amaçlandı. Gereç ve Yöntem: Çalışmada Cumhuriyet Üniversitesi Tıp Fakültesi Araştırma ve Uygulama Hastanesi Onkoloji Merkezinde takip edilen 90 mide kanserli hasta verileri retrospektif olarak incelendi. Bulgular: Çalışmada 68 (%76) erkek, 22 (%24) kadın toplam 90 hastanın verileri analiz edildi. Ortanca takip süresi 19 ay (4-105 ay) idi. İki yıllık genel sağkalım ve hastalıksız sağkalım sırasıyla %62 ve %58 idi. Tek değişkenli analizde hastaların sağkalımını grade (p:0,039), T evre (p:0,001), N evre (p:0,020), kilo kaybı (p: 0,001), ECOG performans durumu (p:0,002), anemi (p:0,019), hipoalbunemi (p:0,001) etkilerken, çok değişkenli analizde bağımsız prognostik faktörler kilo kaybı (p:0,008), T evresi (p:0,024) ve ECOG performans durumu (p:0,033) idi. Hastalarda en sık görülen yan etkiler; bulantı-kusma 66 (%73), dispepsi 52 (%58), anemi 45 (%50), nötropeni 36 (%40), ishal 34 (%38) ve kilo kaybı 29 (%32) hastada görüldü. Sonuç: Bu çalışmada, adjuvan kemoradyoterapi uygulanan mide kanserli hastaların genel ve hastalıksız sağkalımı literatür ile benzer sonuçlar göstermiştir. Bu hasta grubunun en önemli prognostik faktörleri ise kilo kaybı, T evresi ve ECOG performans durumu olarak belirlendi.

Keywords

Mide kanseri, kemoradyoterapi, sağkalım, prognoz

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