Types and frequencies of extraintestinal involvement in our cases with inflammatory bowel disease

Year 2013, Volume: 21 Issue: 1, 15 - 18, 01.04.2013

Atakan Yeşil Ebubekir Şenateş Kadir Kayataş Koray Koçhan Emrullah Düzgün Erdem Banu Erkalma Şenateş Can Gönen

https://doi.org/10.17940/endoskopi.74814

Abstract

Background and Aims:Inflammatory bowel disease includes two important diseases - ulcerative colitis and Crohn's disease. Although they are described as bowel diseases, they also have systemic involvement. In this study, we aimed to determine the types and frequencies of extraintestinal involvement in inflammatory bowel disease cases followed after admission in our clinic and to investigate the relationship of extraintestinal involvement with the disease activity. Materials and Methods:The study was performed on 85 patients with an inflammatory bowel disease diagnosis who were followed in our Gastroenterology Clinic. The study group included 39 patients with Crohn's disease and 46 patients with ulcerative colitis. Results: There was no statistically significant difference between the Crohn's disease group and ulcerative colitis group regarding age, gender, height, body weight, body mass index, erythrocyte sedimentation rate, C-reactive protein, hemoglobin, disease duration, and the frequency of extraintestinal involvement (p>0.05). Average white blood cell count was found to be significantly lower in the Crohn's disease group compared to the ulcerative colitis group (p: 0.003). When the patients were divided into two groups as to the presence or not of extraintestinal involvement, there was no significant difference between the groups regarding age, gender, height, body weight, body mass index, C-reactive protein, erythrocyte sedimentation rate, hemoglobin, white blood cell count, and disease duration (p>0.05). Types of extraintestinal involvement, in order of frequency, were as follows: sacroiliitis (40.7%), arthralgia (11.1%), psoriasis (11.1%) arthritis (7.4%), ankylosing spondylitis (7.4%), iridocyclitis (7.4%), primary sclerosing cholangitis (3.7%), and uveitis (3.7%). No significant correlation was determined between the presence of extraintestinal involvement and disease activity, type of extraintestinal involvement, or areas of involvement on endoscopy in these patients. Conclusion:In conclusion, the extraintestinal involvement rate in our inflammatory bowel diseasepatients was 38.46% in the Crohn's diseasegroup and 26.08% in the ulcerative colitis group, and these rates are in accordance with the literature. It is important that these patients are regularly examined and followed from the time of the diagnosis regarding extraintestinal symptoms

Keywords

Ulcerative colitis, Crohn's disease, extraintestinal involvement

İnflamatuvar barsak hastalığı tanılı olgularımızda ekstraintestinal tutulum tipleri ve sıklığı

Abstract

Amaç: İnflamatuvar barsak hastalıkları; ülseratif kolit ve Crohn hastalığı olarak iki önemli hastalığı içerir. Barsak hastalıkları olarak nitelendirilmelerine rağmen sistemik tutulumları da mevcuttur. Bu çalışmadaki amacımız kliniğimizde yatırarak takip ettiğimiz inflamatuvar barsak hastalarındaki ekstraintestinal tutulum tiplerini ve sıklığını belirlemek, hastalık aktivitesiyle ilişkisini araştırmaktır. Gereç ve Yöntem:Çalışma gastroenteroloji kliniğimizde takip ettiğimiz inflamatuvar barsak hastalıkları tanısı olan 85 hasta üzerinde yapıldı. Hastalar 39 Chron hastası ve 46 ülseratif kolit hastasından oluşmaktaydı. Bulgular:Crohn hastalığı grubu ve ülseratif kolit grubu arasında yaş, cinsiyet, boy, vücut ağırlığı, beden kitle indeksi, eritrosit sedimentasyon hızı, C-reaktif protein, hemoglobin, hastalık süresi, ekstraintestinal tutulum sıklığı açısından istatistiksel anlamlı farklılık bulunmadı (p>0.05). Lökosit sayısı ortalaması Crohn hastalığı grubunda ülseratif kolit grubuna göre anlamlı dü-şük bulundu (p:0.003). Hastalar ekstraintestinal tutulum olup olmamasına göre ikiye ayrıldığında gruplar arasında yaş, cinsiyet, vücut ağırlığı, beden kitle indeksi, C-reaktif protein, eritrosit sedimentasyon hızı, hemoglobin, lökosit sayısı, hastalık süresi açısından anlamlı farklılık bulunmadı (p>0.05). Ekstraintestinal tutulum tipleri sıklık sırasına göre: sakroileit (%40.7), artralji (%11.1), psöriazis (%11.1) artrit (%7.4), ankilozan spondilit (%7.4), iridosiklit (%7.4), primer sklerozan kolanjit (%3.7) ve üveit (%3.7) şeklindeydi. Hastalarda ekstraintestinal tutulum varlığı ile hastalık aktivitesi, tipi ve endoskopik tutulum bölgeleri arasında anlamlı ilişki saptanmadı. Sonuç: Sonuç olarak inflamatuvar barsak hastalarımızda ekstraintestinal tutulum oranı Crohn hastalığı grubunda %38.46, ülseratif kolit grubunda %26.08 olmak üzere, literatürle uyumlu olarak sıktır. Hastaların tanı aldıkları andan itibaren ekstraintestinal bulgular açısından düzenli muayene ve takiplerinin yapılması önemlidir.

Keywords

Ülseratif kolit, Crohn hastalığı, ekstraintestinal tutulum

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