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Kadınlarda Visseral Adipozite İndeksi İle Aşırı Aktif Mesane Semptomları Arasındaki İlişkinin Değerlendirilmesi

Year 2020, Volume: 12 Issue: 2, 150 - 156, 23.07.2020

Abstract

Amaç: Kadın hastalardaki aşırı aktif mesane semptomları ile visseral adipozite indeksi arasında ilişki olup olmadığını araştırmak.

Gereç ve Yöntemler: Ocak 2017 – Haziran 2019 tarihleri arasında kliniğimizde ürodinamik inceleme yapılan hastaların medikal kayıtları retrospektif olarak tarandı. Aşırı Aktif Mesane Sorgulama Formu (OAB-V8) toplam skoru ≥8 ve ürodinamik olarak dolum fazında detrüsör aşırı aktiviteleri gözlemlenen hastalar ile semptom skoru düşük olan ve detrüsör aşırı aktiviteleri gözlenmeyen hastaların demografik, biyokimyasal ve ürodinamik özellikleri istatistiksel olarak karşılaştırıldı.

Bulgular: Çalışmaya yaş ortalaması 48,66±18,58 yıl olan toplam 58 kadın olgu dahil edildi. Olguların 28 (%48,3)’i aşırı aktif mesane grubunda (Grup 1) yer alırken, 30 (%51,7)’u kontrol grubunda (Grup 2) yer aldı. Gruplar arasında ortalama yaş dağılımları açısından istatistiksel olarak anlamlı farklılık saptanmadı (p>0,05). Grup 1’de yer alan hasta ağırlığı ortalama değerinin Grup 2’de yer alan hastalara göre istatistiksel olarak anlamlı şekilde daha yüksek olduğu izlendi (p=0,041). Grup 1’de visseral adipozite indeksi (VAİ) ortanca değeri [3,3 (0,7 – 14,5)] Grup 2’deki VAİ ortanca değerinden [2,5 (1,2 – 11,7)] daha yüksek olmasına rağmen gruplar arasında istatistiksel olarak anlamlı farklılık görülmedi (p>0,05).

Sonuç: Aşırı aktif mesane semptomları olan kadınlarda VAİ ortanca değeri aşırı aktif mesane semptomları olmayan kadınlara göre daha yüksek olarak izlense de gruplar arasında istatistiksel olarak anlamlı farklılık görülmemiştir.

References

  • 1. Haylen BT, de Ridder D, Freeman RM et al. (2010) An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. Neurourol Urodyn 29 (1):4-20. doi:10.1002/nau.20798
  • 2. Irwin DE, Kopp ZS, Agatep B, Milsom I, Abrams P (2011) Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction. BJU Int 108 (7):1132-1138. doi:10.1111/j.1464-410X.2010.09993.x
  • 3. Kim SY, Bang W, Choi HG (2017) Analysis of the prevalence of and factors associated with overactive bladder in adult Korean women. PLoS One 12 (9):e0185592. doi:10.1371/journal.pone.0185592
  • 4. Link CL, Steers WD, Kusek JW, McKinlay JB (2011) The association of adiposity and overactive bladder appears to differ by gender: results from the Boston Area Community Health survey. J Urol 185 (3):955-963. doi:10.1016/j.juro.2010.10.048 5. Uzun H, Yilmaz A, Kemik A, Zorba OU, Kalkan M (2012) Association of insulin resistance with overactive bladder in female patients. Int Neurourol J 16 (4):181-186. doi:10.5213/inj.2012.16.4.181
  • 6. Aung K, Lorenzo C, Hinojosa MA, Haffner SM (2014) Risk of developing diabetes and cardiovascular disease in metabolically unhealthy normal-weight and metabolically healthy obese individuals. J Clin Endocrinol Metab 99 (2):462-468. doi:10.1210/jc.2013-2832
  • 7. Després JP (2006) Intra-abdominal obesity: an untreated risk factor for Type 2 diabetes and cardiovascular disease. J Endocrinol Invest 29 (3 Suppl):77-82
  • 8. Ferreira FG, Juvanhol LL, Silva-Costa A, Longo GZ (2020) The mediating role of visceral adiposity in the relationship among schooling, physical inactivity, and unhealthy metabolic phenotype. Am J Hum Biol:e23425. doi:10.1002/ajhb.23425
  • 9. Amato MC, Giordano C (2013) Clinical indications and proper use of Visceral Adiposity Index. Nutr Metab Cardiovasc Dis 23 (8):e31-32. doi:10.1016/j.numecd.2013.04.006
  • 10. Coyne K, Revicki D, Hunt T, Corey R, Stewart W, Bentkover J et al. (2002) Psychometric validation of an overactive bladder symptom and health-related quality of life questionnaire: the OAB-q. Qual Life Res 11 (6):563-574. doi:10.1023/a:1016370925601
  • 11. Dallosso HM, McGrother CW, Matthews RJ, Donaldson MM (2003) The association of diet and other lifestyle factors with overactive bladder and stress incontinence: a longitudinal study in women. BJU Int 92 (1):69-77. doi:10.1046/j.1464-410x.2003.04271.x
  • 12. McGrother CW, Donaldson MM, Thompson J, Wagg A, Tincello DG, Manktelow BN (2012) Etiology of overactive bladder: a diet and lifestyle model for diabetes and obesity in older women. Neurourol Urodyn 31 (4):487-495. doi:10.1002/nau.21200
  • 13. Chancellor MB, Oefelein MG, Vasavada S (2010) Obesity is associated with a more severe overactive bladder disease state that is effectively treated with once-daily administration of trospium chloride extended release. Neurourol Urodyn 29 (4):551-554. doi:10.1002/nau.20787
  • 14. Richter HE, Creasman JM, Myers DL, Wheeler TL, Burgio KL, Subak LL (2008) Urodynamic characterization of obese women with urinary incontinence undergoing a weight loss program: the Program to Reduce Incontinence by Diet and Exercise (PRIDE) trial. Int Urogynecol J Pelvic Floor Dysfunct 19 (12):1653-1658. doi:10.1007/s00192-008-0694-8
  • 15. Handa VL, Pierce CB, Muñoz A, Blomquist JL (2015) Longitudinal changes in overactive bladder and stress incontinence among parous women. Neurourol Urodyn 34 (4):356-361. doi:10.1002/nau.22583
  • 16. Carroll JF, Chiapa AL, Rodriquez M, Phelps DR, Cardarelli KM, Vishwanatha JK et al. (2008) Visceral fat, waist circumference, and BMI: impact of race/ethnicity. Obesity (Silver Spring) 16 (3):600-607. doi:10.1038/oby.2007.92
  • 17. Dursun M, Otunctemur A, Ozbek E, Sahin S, Besiroglu H, Koklu I (2014) Stress urinary incontinence and visceral adipose index: a new risk parameter. Int Urol Nephrol 46 (12):2297-2300. doi:10.1007/s11255-014-0832-9
  • 18. Amato MC, Giordano C, Galia M, Criscimanna A, Vitabile S, Midiri M et al. (2010) Visceral Adiposity Index: a reliable indicator of visceral fat function associated with cardiometabolic risk. Diabetes care 33 (4):920-922
  • 19. Eren H, Horsanalı MO, Ozbek E (2019) Postmenozal kadınlarda visseral adipozite indeksi ve aşırı aktif mesane: Yeni bir risk belirteci. Kocaeli Tıp Dergisi 8 (2):84-89
  • 20. Bunn F, Kirby M, Pinkney E, Cardozo L, Chapple C, Chester K et al. (2015) Is there a link between overactive bladder and the metabolic syndrome in women? A systematic review of observational studies. Int J Clin Pract 69 (2):199-217. doi:10.1111/ijcp.12518
  • 21. Uzun H, Zorba O (2012) Metabolic syndrome in female patients with overactive bladder. Urology 79 (1):72-75. doi:10.1016/j.urology.2011.08.050

Evaluation of relationship between visceral adiposity ındex and overactivate bladder symptoms in females

Year 2020, Volume: 12 Issue: 2, 150 - 156, 23.07.2020

Abstract

Objective: To investigate the relationship between overactive bladder syndrome and visceral adiposity index (VAI).
Material and Methods: The results of urodynamic tests performed between January 2017 and June 2019 were evaluated retrospectively. Patients with a total “Overactive Bladder Symptom Score Questionnaire” (OAB-V8) score of 8 and above with overactivated detrusor muscle during the filling phase of urodynamic studies and patients with lower scores of OAB-V8 without overactivation in detrusor muscle were compared in terms of demographic features, biochemical parameters and VAI values. 
Results: The study group comprised of 58 female subjects with a mean age of 48,66±18,58 years. 48,3% (n=28) of the patients were included in the overactive bladder group while 51,7% (n=30) were in the control group. No significant difference was observed between two groups in term of age (p>0,05). Weight measures showed significant difference between two groups and the weight measures of the patients in overactivated bladder group were found to be higher than in healthy controls (p=0,041; p<0,05). Although no significant difference was observed in VAI values between two groups (p>0,05); the VAI values were shown to be higher in overactivated bladder patients than in healthy controls (median [2,5 (1,2 – 11,7)] vs [3,3 (0,7 – 14,5); respectively).
Conclusion: In our study, median VAI values were shown to be higher in females with overactivated bladder symptoms, however the results were not statistically significant. 

References

  • 1. Haylen BT, de Ridder D, Freeman RM et al. (2010) An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. Neurourol Urodyn 29 (1):4-20. doi:10.1002/nau.20798
  • 2. Irwin DE, Kopp ZS, Agatep B, Milsom I, Abrams P (2011) Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction. BJU Int 108 (7):1132-1138. doi:10.1111/j.1464-410X.2010.09993.x
  • 3. Kim SY, Bang W, Choi HG (2017) Analysis of the prevalence of and factors associated with overactive bladder in adult Korean women. PLoS One 12 (9):e0185592. doi:10.1371/journal.pone.0185592
  • 4. Link CL, Steers WD, Kusek JW, McKinlay JB (2011) The association of adiposity and overactive bladder appears to differ by gender: results from the Boston Area Community Health survey. J Urol 185 (3):955-963. doi:10.1016/j.juro.2010.10.048 5. Uzun H, Yilmaz A, Kemik A, Zorba OU, Kalkan M (2012) Association of insulin resistance with overactive bladder in female patients. Int Neurourol J 16 (4):181-186. doi:10.5213/inj.2012.16.4.181
  • 6. Aung K, Lorenzo C, Hinojosa MA, Haffner SM (2014) Risk of developing diabetes and cardiovascular disease in metabolically unhealthy normal-weight and metabolically healthy obese individuals. J Clin Endocrinol Metab 99 (2):462-468. doi:10.1210/jc.2013-2832
  • 7. Després JP (2006) Intra-abdominal obesity: an untreated risk factor for Type 2 diabetes and cardiovascular disease. J Endocrinol Invest 29 (3 Suppl):77-82
  • 8. Ferreira FG, Juvanhol LL, Silva-Costa A, Longo GZ (2020) The mediating role of visceral adiposity in the relationship among schooling, physical inactivity, and unhealthy metabolic phenotype. Am J Hum Biol:e23425. doi:10.1002/ajhb.23425
  • 9. Amato MC, Giordano C (2013) Clinical indications and proper use of Visceral Adiposity Index. Nutr Metab Cardiovasc Dis 23 (8):e31-32. doi:10.1016/j.numecd.2013.04.006
  • 10. Coyne K, Revicki D, Hunt T, Corey R, Stewart W, Bentkover J et al. (2002) Psychometric validation of an overactive bladder symptom and health-related quality of life questionnaire: the OAB-q. Qual Life Res 11 (6):563-574. doi:10.1023/a:1016370925601
  • 11. Dallosso HM, McGrother CW, Matthews RJ, Donaldson MM (2003) The association of diet and other lifestyle factors with overactive bladder and stress incontinence: a longitudinal study in women. BJU Int 92 (1):69-77. doi:10.1046/j.1464-410x.2003.04271.x
  • 12. McGrother CW, Donaldson MM, Thompson J, Wagg A, Tincello DG, Manktelow BN (2012) Etiology of overactive bladder: a diet and lifestyle model for diabetes and obesity in older women. Neurourol Urodyn 31 (4):487-495. doi:10.1002/nau.21200
  • 13. Chancellor MB, Oefelein MG, Vasavada S (2010) Obesity is associated with a more severe overactive bladder disease state that is effectively treated with once-daily administration of trospium chloride extended release. Neurourol Urodyn 29 (4):551-554. doi:10.1002/nau.20787
  • 14. Richter HE, Creasman JM, Myers DL, Wheeler TL, Burgio KL, Subak LL (2008) Urodynamic characterization of obese women with urinary incontinence undergoing a weight loss program: the Program to Reduce Incontinence by Diet and Exercise (PRIDE) trial. Int Urogynecol J Pelvic Floor Dysfunct 19 (12):1653-1658. doi:10.1007/s00192-008-0694-8
  • 15. Handa VL, Pierce CB, Muñoz A, Blomquist JL (2015) Longitudinal changes in overactive bladder and stress incontinence among parous women. Neurourol Urodyn 34 (4):356-361. doi:10.1002/nau.22583
  • 16. Carroll JF, Chiapa AL, Rodriquez M, Phelps DR, Cardarelli KM, Vishwanatha JK et al. (2008) Visceral fat, waist circumference, and BMI: impact of race/ethnicity. Obesity (Silver Spring) 16 (3):600-607. doi:10.1038/oby.2007.92
  • 17. Dursun M, Otunctemur A, Ozbek E, Sahin S, Besiroglu H, Koklu I (2014) Stress urinary incontinence and visceral adipose index: a new risk parameter. Int Urol Nephrol 46 (12):2297-2300. doi:10.1007/s11255-014-0832-9
  • 18. Amato MC, Giordano C, Galia M, Criscimanna A, Vitabile S, Midiri M et al. (2010) Visceral Adiposity Index: a reliable indicator of visceral fat function associated with cardiometabolic risk. Diabetes care 33 (4):920-922
  • 19. Eren H, Horsanalı MO, Ozbek E (2019) Postmenozal kadınlarda visseral adipozite indeksi ve aşırı aktif mesane: Yeni bir risk belirteci. Kocaeli Tıp Dergisi 8 (2):84-89
  • 20. Bunn F, Kirby M, Pinkney E, Cardozo L, Chapple C, Chester K et al. (2015) Is there a link between overactive bladder and the metabolic syndrome in women? A systematic review of observational studies. Int J Clin Pract 69 (2):199-217. doi:10.1111/ijcp.12518
  • 21. Uzun H, Zorba O (2012) Metabolic syndrome in female patients with overactive bladder. Urology 79 (1):72-75. doi:10.1016/j.urology.2011.08.050
There are 20 citations in total.

Details

Primary Language English
Subjects Urology
Journal Section Research Articles
Authors

Emre Karabay 0000-0003-1654-8524

Nejdet Karşıyakalı 0000-0002-0709-0331

Kemal Kayar This is me 0000-0003-0731-9877

Levent Verim 0000-0002-5295-5410

Çağatay Tosun This is me 0000-0001-8221-8158

Ömer Yücebaş This is me 0000-0002-8161-4068

Publication Date July 23, 2020
Published in Issue Year 2020 Volume: 12 Issue: 2

Cite

Vancouver Karabay E, Karşıyakalı N, Kayar K, Verim L, Tosun Ç, Yücebaş Ö. Evaluation of relationship between visceral adiposity ındex and overactivate bladder symptoms in females. Endourol Bull. 2020;12(2):150-6.