Impact of statin use on perioperative bleeding in patients with benign prostatic hyperplasia who underwent monopolar TURP

Year 2021, Volume: 13 Issue: 3, 85 - 92, 29.12.2021

Erkan Ölçücüoğlu , Emre Uzun , Sedat Taştemur , Yusuf Kasap , Samet Şenel

https://doi.org/10.54233/endouroloji.1003075

Abstract

Objective: We aimed to evaluate the effect of statin use on bleeding complications in benign prostate hyperplasia (BPH) patients who underwent transurethral resection of the prostate (TURP).
Material and Methods: This prospective case-control study included patients with benign prostatic hyperplasia (BPH) who underwent TURP surgery. Seventy-six patients were included (30 statin users and 74 statin non-users). Data including patient age, preoperative laboratory values(complete blood count, prostate-specific antigen (PSA) levels, prostate volume, international normalized ratio (INR), activated partial thromboplastin time (aPTT)), intraoperative characteristics(amount of resected prostate tissue, blood transfusion, duration of surgery, duration of urinary catheterization) and postoperative features(serum complete blood count, and length of hospital stay)were collected. Patients who underwent TURP with or without statin use were compared with hematocrit and bleeding complications.
Results: There was no difference between the groups regarding the degree of reduction in hematocrit and platelet count. In both groups, postoperative hematocrit and platelet counts were significantly lower than preoperative values. There was no significant difference between the groups regarding age, PSA, prostate volume, histopathological diagnosis, transurethral resection (TUR) volume, INR, PT, aPTT, number of red blood cell (RBC) units transfused, duration of surgery, irrigation time, hematocrit, and platelet count. TUR volume, frequency of anticoagulant use, duration, and length of hospital stay were statistically higher in the statin user group
Conclusion: Our results showed that statin use did not impact bleeding in patients with BPH who underwent TURP. Considering the widespread use of statins, during surgery the effects of bleeding, we need more information on further studies to light.

Keywords

benign prostatic hyperplasia, bleeding, statin, transurethral resection of the prostate

Benign prostat hiperplazi nedeniyle transüretral prostat rezeksiyonu uygulanan hastalarda statin kullanımının perioperatif kanamaya etkisi

Abstract

Amaç: Transüretral prostat rezeksiyonu (TURP) uygulanan benign prostat hiperplazisi (BPH) hastalarında statin kullanımının kanama komplikasyonu üzerine etkisini değerlendirmeyi amaçladık.
Gereç ve Yöntemler: Bu çalışma TURP ameliyatı geçirmiş BPH hastalarını içeren prospektif bir vaka-kontrol çalışmasıdır. Çalışmaya yetmiş altı hasta dahil edildi (30 statin kullanıcısı ve 74 statin kullanmayan). Hasta yaşı, ameliyat öncesi laboratuvar değerleri (tam kan sayımı, prostat spesifik antijen (PSA) seviyeleri, prostat hacmi, uluslararası normalleştirilmiş oran (INR), aktif parsiyel tromboplastin zamanı (aPTT)), intraoperatif özellikler (rezeke edilen prostat dokusu miktarı, kan transfüzyonu, ameliyat süresi, üriner kateterizasyon süresi) ve ameliyat sonrası özellikler (serum tam kan sayımı ve hastanede kalış süresi) değerlendirildi. Statin kullanan ve kullanmayan TURP yapılan hastalar hematokrit değerleri ve kanama komplikasyonları açısından karşılaştırıldı.
Bulgular: Hematokrit ve trombosit sayısındaki azalma düzeyi açısından gruplar arasında fark yoktu. Her iki grupta da ameliyat sonrası hematokrit ve trombosit sayıları ameliyat öncesi değerlere göre anlamlı derecede düşüktü. Gruplar arasında yaş, PSA, prostat hacmi, histopatolojik tanı, transüretral rezeksiyon (TUR) hacmi, INR, PT, aPTT, transfüze edilen kan miktarı, ameliyat süresi, irrigasyon süresi, hematokrit ve trombosit sayısı açısından anlamlı fark yoktu. Statin kullanan grupta TUR hacmi, antikoagülan kullanım sıklığı, kateterizasyon süresi ve hastanede kalış süresi istatistiksel olarak daha yüksekti.
Sonuç: Sonuçlarımız, TURP uygulanan BPH’lı hastalarda statin kullanımının kanamayı etkilemediğini gösterdi. Statinlerin yaygın kullanımı göz önüne alındığında, ameliyat sırasında kanama üzerindeki etkilerine ışık tutacak daha fazla çalışmaya ihtiyaç vardır.

Keywords

benign prostat hiperplazisi; kanama; prostatın transüretral rezeksiyonu; statin

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