Year 2020, Volume 10 , Issue 1, Pages 296 - 299 2020-04-25

Langerhans’ cell histiocytosis (LCH) is a rare group of diseases characterized by abnormal clonal proliferation of Langerhans cells in one or more systems. LCH can occur in any system. We report a case of bilateral otologic LCH that presented as a case of mastoiditis. Despite multiple courses of antibiotics, there was no improvement. Subsequent excision biopsy of a postauricular mass confirmed the diagnosis of LCH. The patient responded well to chemotherapy.
Histiocytosis, Langerhans-Cell, otological diseases, mastoiditis
  • 1. Nicholson HS, Egeler RM, Nesbit ME. The epidemiology of Langerhans cell histiocytosis. Hematol Oncol Clin North Am 1998;12:379-84.
  • 2. Leung AKC, Lam JM, Leong KF. Childhood Langerhans cell histiocytosis: a disease with many faces. World J Pediatr 2019;15:536-45.
  • 3. Irving RM, Broadbent V, Jones NS. Langerhans’ cell histiocytosis in childhood: management of head and neck manifestations. Laryngoscope 1994;104:64-70.
  • 4. Saliba I, Sidani K, El Fata F, Arcand P, Quintal MC, Abela A. Langerhans’ cell histiocytosis of the temporal bone in children. Int J Pediatr Otorhinolaryngol 2008;72:775-86.
  • 5. Azouz EM, Saigal G, Rodriguez MM, Podda A. Langerhans’ cell histiocytosis:pathology, imaging and treatment of skeletal involvement. Pediatr Radiol 2005;35:103-15.
  • 6. Fernández-Latorre F, Menor-Serrano F, Alonso-Charterina S, Arenas-Jiménez J. Langerhans’ cell histiocytosis of the temporal bone in pediatric patients: imaging and follow-up. AJR Am J Roentgenol 2000;174:217-21.
  • 7. Howarth DM, Gilchrist GS, Mullan BP, Wiseman GA, Edmonson JH, Schomberg PJ. Langerhans cell histiocytosis: diagnosis, natural history, management, and outcome. Cancer 1999;85:2278-90.
  • 8. Minkov M. Multisystem Langerhans cell histiocytosis in children: current treatment and future directions. Paediatr Drugs 2011;13:75-86.
  • 9. Haupt R, Minkov M, Astigarraga I, et al. Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years. Pediatr Blood Cancer 2013;60:175-84.
  • 10. Goldsmith AJ, Myssiorek D, Valderrama E, Patel M. Unifocal Langerhans’ cell histiocytosis (eosinophilic granuloma) of the petrous apex. Arch Otolaryngol Head Neck Surg 1993;119:113-6.
  • 11. Hermans R, De Foer B, Smet MH, et al. Eosinophilic granuloma of the head and neck: CT and MRI features in three cases. Pediatr Radiol 1994;24:33-6.
  • 12. McCaffrey TV, McDonald TJ. Histiocytosis X of the ear and temporal bone: review of 22 cases. Laryngoscope 1979;89:1735-42.
  • 13. D’Ambrosio N, Soohoo S, Warshall C, Johnson A, Karimi S. Craniofacial and intracranial manifestations of langerhans cell histiocytosis: report of findings in 100 patients. AJR Am J Roentgenol 2008;191:589-97.
  • 14. Wenig BM, Abbondanzo SL, Childers EL, Kapadia SB, Heffner DR. Extranodal sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) of the head and neck. Hum Pathol 1993;24:483-92.
  • 15. Lau SK, Chu PG, Weiss LM. Immunohistochemical expression of Langerin in Langerhans cell histiocytosis and non-Langerhans cell histiocytic disorders. Am J Surg Pathol 2008;32:615-9.
  • 16. Levy R, Sarfaty SM, Schindel J. Eosinophilic granuloma of the temporal bone. Two cases with bilateral involvement. Arch Otolaryngol 1980;106:167-71.
  • 17. Mardi K, Thakur RC, Negi L. Intradural Eosinophilic Granuloma Invading Skull: Case Report and Review of the Literature. Asian J Neurosurg 2017;12:698-700.
Primary Language en
Subjects Health Care Sciences and Services
Journal Section Articles
Authors

Orcid: 0000-0002-1846-5151
Author: Foong SEONG KIN
Institution: Queen Elizabeth Hospital
Country: Malaysia


Orcid: 0000-0002-1277-0905
Author: Ong CHENG AI
Institution: Queen Elizabeth Hospital
Country: Malaysia


Orcid: 0000-0003-3899-8833
Author: Faezahtul Arbaeyah HUSSAIN
Institution: Universiti Sains Malaysia
Country: Malaysia


Orcid: 0000-0002-5535-2930
Author: Bee See GOH (Primary Author)
Institution: Hospital Universiti Kebangsaan Malaysia
Country: Malaysia


Dates

Application Date : January 14, 2020
Acceptance Date : March 10, 2020
Publication Date : April 25, 2020

Bibtex @case report { entupdates673014, journal = {ENT Updates}, issn = {2149-7109}, eissn = {2149-6498}, address = {}, publisher = {Sürekli Eğitim ve Bilimsel Araştırmalar Derneği}, year = {2020}, volume = {10}, pages = {296 - 299}, doi = {10.32448/entupdates.673014}, title = {A great mimicker of mastoiditis: Multisystem Langerhans’ cell histiocytosis}, key = {cite}, author = {Seong Kın, Foong and Cheng Aı, Ong and Hussaın, Faezahtul Arbaeyah and Goh, Bee See} }
APA Seong Kın, F , Cheng Aı, O , Hussaın, F , Goh, B . (2020). A great mimicker of mastoiditis: Multisystem Langerhans’ cell histiocytosis . ENT Updates , 10 (1) , 296-299 . DOI: 10.32448/entupdates.673014
MLA Seong Kın, F , Cheng Aı, O , Hussaın, F , Goh, B . "A great mimicker of mastoiditis: Multisystem Langerhans’ cell histiocytosis" . ENT Updates 10 (2020 ): 296-299 <https://dergipark.org.tr/en/pub/entupdates/issue/53920/673014>
Chicago Seong Kın, F , Cheng Aı, O , Hussaın, F , Goh, B . "A great mimicker of mastoiditis: Multisystem Langerhans’ cell histiocytosis". ENT Updates 10 (2020 ): 296-299
RIS TY - JOUR T1 - A great mimicker of mastoiditis: Multisystem Langerhans’ cell histiocytosis AU - Foong Seong Kın , Ong Cheng Aı , Faezahtul Arbaeyah Hussaın , Bee See Goh Y1 - 2020 PY - 2020 N1 - doi: 10.32448/entupdates.673014 DO - 10.32448/entupdates.673014 T2 - ENT Updates JF - Journal JO - JOR SP - 296 EP - 299 VL - 10 IS - 1 SN - 2149-7109-2149-6498 M3 - doi: 10.32448/entupdates.673014 UR - https://doi.org/10.32448/entupdates.673014 Y2 - 2020 ER -
EndNote %0 ENT Updates A great mimicker of mastoiditis: Multisystem Langerhans’ cell histiocytosis %A Foong Seong Kın , Ong Cheng Aı , Faezahtul Arbaeyah Hussaın , Bee See Goh %T A great mimicker of mastoiditis: Multisystem Langerhans’ cell histiocytosis %D 2020 %J ENT Updates %P 2149-7109-2149-6498 %V 10 %N 1 %R doi: 10.32448/entupdates.673014 %U 10.32448/entupdates.673014
ISNAD Seong Kın, Foong , Cheng Aı, Ong , Hussaın, Faezahtul Arbaeyah , Goh, Bee See . "A great mimicker of mastoiditis: Multisystem Langerhans’ cell histiocytosis". ENT Updates 10 / 1 (April 2020): 296-299 . https://doi.org/10.32448/entupdates.673014
AMA Seong Kın F , Cheng Aı O , Hussaın F , Goh B . A great mimicker of mastoiditis: Multisystem Langerhans’ cell histiocytosis. ENT Updates. 2020; 10(1): 296-299.
Vancouver Seong Kın F , Cheng Aı O , Hussaın F , Goh B . A great mimicker of mastoiditis: Multisystem Langerhans’ cell histiocytosis. ENT Updates. 2020; 10(1): 296-299.