Bir Yarış Güvercini (Columba livia domestica) Sürüsünde Aspergillus fumigatus Salgınının Araştırılması

Abstract

Bu çalışmada yarış güvercinlerinde (Columba livia domestica) Aspergillus fumigatus’un neden olduğu sistemik aspergillozis salgınının klinik seyri, patolojik bulguları ve muhtemel risk faktörleri araştırıldı. Yüzyirmi adet yarış güverci- ni bulunan sürüde yoğun egzersiz periyodu ile ilişkili hastalık salgını rapor edildi. Hastalığın ortaya çıkışı yoğun egzer- siz programı ve hava sıcaklıklarının yüksek seviyelerde seyretmesi ile ilişkiliydi. Etkilenen kanatlılarda halsizlik, çabuk yorulma, depresif durum, ayağa kalkamama, hızlı gelişen zayıflama, inkoordinasyon, çırpınma gibi belirtiler ve ölüm görüldü. Nekropside akciğer, hava keseleri ve viseral peritoneumun yüzeyinde değişen büyüklüklerde, nodüller veya plak benzeri lezyonlar dikkati çekti. Histopatolojik olarak parenkimatöz organları etkileyen ve bu organların çevresindeki dokulara invazyon gösteren fungal heterofilik granülomlar belirlendi. Santral sinir sisteminde fungal yapılar ile ilişkili malasik lezyonlar görüldü. Histopatolojik ve sitolojik bulgular A. fumigatus’a ilişkin karakteristik bulguları ortaya koydu. Hastalığın çıkış döneminde hava sıcaklıklarının mevsim normallerinin üstünde seyretmesi ve bu tarihlerde yarışlara hazırlık için güvercinlere yoğun egzersiz yaptırıldığı göz önüne alındığında A. fumigatus’un güvercinlerde kolonize olarak yayılmasında bu faktörlerin olası rolü olduğu düşünüldü.

Keywords

• Aspergillozis
• egzersiz
• patoloji
• predispozan faktörler
• yarış güvercini

Investigating an Outbreak of Aspergillus fumigatus Infection in a Racing Pigeon (Columba livia domestica) Flock

Abstract

In this study, the clinical course, pathological findings, and potential risk factors of a systemic aspergillosis outbreak caused by Aspergillus fumigatus in racing pigeons (Columba livia domestica) were investigated. The disease was reported during the period of intense exercise in a 120 head racing pigeon flock. The exercise period coincided with the high environmental temperatures. Affected birds displayed symptoms, such as weakness, fatigue, depression, inability to stand, rapidly developing weakness, incoordination, convulsions, and death. Necropsy revealed varying sized, prominent nodular or plaque-like lesions on the lungs, air sacs, and visceral peritoneum. Single or multiple case- onecrotic fungal granulomas invading the existing and/or adjacent tissues were seen histopathologically. Malacic le- sions associated with fungal elements were observed in the central nervous system. Histopathologic and cytological findings revealed the presence of characteristic A. fumigatus elements and lesions. Considering the fact that the envi- ronmental temperatures were above the seasonal norms during the emergence of the disease as well as subjugation of pigeons to intense exercise for race preparations, A. fumigatus colonization and its spread in racing pigeons was seen likely due to the combined effects of these risk factors.

Keywords

• Aspergillosis
• exercise
• pathology
• predisposing factors
• racing pigeon

References

1. Akan M, Haziroglu R, lhan Z, Sareyyüpoğlu B, Tunca R. A case of aspergillosis in a broiler breeder flock. Avian Dis 2002; 46(2): 497-501.
2. Arné P, Thierry S, Wang D, Deville M, Le Loc'h G, Desoutter A, Féménia F, Nieguitsila A, Huang W, Chermette R, Guillot J. Aspergillus fumigatus in poultry. Int J Microbiol 2011; 2011 :746356.
3. Arné P, Lee MD. Fungal infections. Swayne DE. ed. In: Diseases of Poultry. Fourteenth Edition. Hobo- ken, NJ, USA: Wiley‐Blackwell, 2020 pp. 1109-33.
4. Aslan Ö, Yaman D, Karaca Bekdik İ, Abay S. Ekebaş G. Bir güvercin sürüsünde Aspergillus fumigatus- enfeksiyonu. Erciyes Üniv Vet Fak Derg 2015; 12 (2), 147-52.
5. Atasever A, Gümüşsoy KS. Pathological, clinical and mycological findings in experimental aspergillosis infections of starlings. J Vet Med A Physiol Pathol Clin Med 2004; 51(1): 19-22.
6. Barton JT, Daft BM, Read DH, Kinde H, Bickford AA. Tracheal aspergillosis in 6 1/2-week-old chickens caused by Aspergillus flavus. Avian Dis 1992; 36 (4): 1081-5.
7. Beckman BJ, Howe CW, Trampel DW, DeBey MC, Richard JL, Niyo Y. Aspergillus fumigatus keratitis with intraocular invasion in 15-day-old chicks. Avian Dis 1994; 38(3): 660-5.
8. Beyaz L, Gümüşsoy KS, Çam Y, Abay S, Atasever A. Kayseri Hayvanat Bahçesi’nde bulunan bazı yabani kanatlı türlerinde rastlanan sistemik asper- gillozis. Ankara Univ Vet Fak Derg 2008; 55(1):31-5.

9. Beytut E, Ozcan K, Erginsoy S. Immunohistochemi- cal detection of fungal elements in the tissues of goslings with pulmonary and systemic aspergillo- sis. Acta Vet Hung 2004; 52(1): 71-84.
10. Cafarchia C, Camarda A, Iatta R, Danesi P, Favuzzi V, Di Paola G, Pugliese N, Caroli A, Montagna MT, Otranto D. Environmental contamination by Aspergillus spp. in laying hen farms and associat- ed health risks for farm workers. J Med Microbiol 2014; 63(3): 464-70.
11. Caplin A, Chen FS, Beauchamp MR, Puterman E. The effects of exercise intensity on the cortisol response to a subsequent acute psychosocial stressor. Psychoneuroendocrinology 2021; 131: 105336.
12. Dalton JR, Ainsworth H. Mycotic keratoconjunctivitis in 12-day-old red-legged partridges (Alectoris rufa). Vet Rec 2011; 168(22): 90.
13. Fulleringer SL, Seguin D, Warin S, Bezille A, Desterque C, Arné P, Chermette R, Bretagne S, Guillot J. Evolution of the environmental contami- nation by thermophilic fungi in a turkey confine- ment house in France. Poult Sci 2006; 85(11): 1875-80.
14. Gulcubuk A., Erdogan-Bamac O, Metiner K, Yuzbasi- oglu Ozturk G, Ozgur Y, Haktanır D. A case of pulmonary aspergillosis in white storks. J Hellenic Vet Med Soc 2018; 69(2): 1004-9.
15. Hazıroğlu R, Şahal M, Tunca R, Güvenç T, Duru SY, Ataseven L. Pleuritis and pneumonia associated with nocardiosis and aspergillosis in a domestic short haired cat. Ankara Univ Vet Fak Derg 2006; 53(2): 149-51.
16. Hubben K. Case report: Aspergillus meningo- encephalitis in turkeys and ducks. Avian Dis 1958; 2(1). 110-6.
17. Jensen HE, Christensen JP, Bisgaard M, Nielsen OL. Immunohistochemistry for the diagnosis of asper- gillosis in turkey poults. Avian Pathol 1997; 26(1): 5-18.
18. Kruk J, Kotarska K, Aboul-Enein BH. Physical exer- cise and catecholamines response: Benefits and health risk: Possible mechanisms. Free Radic Res 2020; 54(2-3): 105-25.
19. Kunkle RA, Rimler RB. Pathology of acute aspergillo- sis in turkeys. Avian Dis 1996; 40(4): 875-86.
20. Martin MP, Bouck KP, Helm J, Dykstra MJ, Wages DP, Barnes HJ. Disseminated Aspergillus flavus infection in broiler breeder pullets. Avian Dis2007; 51(2): 626-31.
21. Ozmen O, Dorrestein MG. Observations of aspergil- losis in the brains of turkey poults using different histopathological staining techniques. Biotech Histochem 2004; 79(2): 95-9.
22. Özmen O, Albay MK, Halıgür M, Şahinduran Ş. Clini- copathological findings on naturally occurring aspergillosis in pigeons. MAKÜ Sag Bil Enst Derg 2013; 1(1): 1-10.
23. Richard JL, Cutlip RC, Thurston JR, Songer J. Re- sponse of turkey poults to aerosolized spores of Aspergillus fumigatus and aflatoxigenic and no- naflatoxigenic strains of Aspergillus flavus. Avian Dis 1981; 25(1): 53-67.
24. Richard JL, Thurston JR, Cutlip RC, Pier AC. Vac- cination studies of aspergillosis in turkeys: Subcu- taneous inoculation with several vaccine prepara- tions followed by aerosol challenge exposure. Am J Vet Res 1982; 43(3): 488-92.
25. Richard JL, Thurston JR, Peden WM, Pinello C. Re- cent studies on aspergillosis in turkey poults. My- copathologia 1984; 87(1): 3-11.
26. Richard JL, Thurston JR. Rapid hematogenous dissemination of Aspergillus fumigatus and A. flavus spores in turkey poults following aerosol expo- sure. Avian Dis 1983; 27(4): 1025-33.
27. Thierry S, Durand B, Melloul E, Tafani JP, Wang DY, Deville M, Cordonnier N, Chermette R, Guillot J, Arné P. Assessment of Aspergillus fumigatus pathogenicity in aerosol-challenged chickens (Gallus gallus) belonging to two lineages. Comp Immunol Microbiol Infect Dis 2013; 36(4): 379-85.
28. Tunca R, Güvenç T, Hazıroğlu R, Ataseven L, Özen H, Toplu N. Pathological and Immunohistochemi- cal investigation of naturally occurring systemic Candida albicansinfection in Dogs. Turk J Vet Anim Sci 2006; 30(6): 545-51.
29. Tunca R, Hazıroğlu R. Kobaylarda deneysel Candida albicans enfeksiyonunda patolojik bulgular. Anka- ra Univ Vet Fak Derg 2004; 51: 133-42.