Evcil Güvercinlerde Deksmedetomidin ve Deksmedetomidin-Ketamin Kombinasyonunun Anestezik Özel-likleri ile Reversal Bir Ajan Olarak Atipamezolün Değerlendirilmesi

Abstract

Bu çalışmanın amacı evcil güvercinlerde (Columba livia) deksmedetomidin ve ketaminin tek başına ve deksme-detomidin-ketamin kombinasyonunun anestezik etkinliğini ve α2 adrenerjik antagonisti atipamezolün etkilerini belir-lemektir. DX grubuna deksmedetomidin (80 μg/kg), K grubuna ketamin (100 mg/kg) tek başına, DXK grubuna ise deks-medetomidin (40 μg/kg) ve ketamin (50 mg/kg) art arda kasiçi (IM) yolla uygulandı. Anestezi derinliği ile kardiyopulmo-ner bulgular enjeksiyon öncesinden (T0) 60. dakikaya (T60) kadar izlendi. T60'da IM yolla atipamezol, deksmedetomi-dinin 4 katı dozda DX (320 μg/kg) ve DXK gruplarına (160 μg/kg) enjekte edildi. DX grubundaki güvercinlerde yalnızca minimal seviyede sedasyon ile bradikardi ve solunum sayısında ani düşme görüldü (P<0.05). DXK grubunda kardiyo-pulmoner değerler DX grubuna göre daha az etkilendi. DXK grubunda atipamezol enjeksiyonundan 22.47±0.64 dk sonra tüm güvercinler ayaktaydı. Sonuç olarak deksmedetomidin (80 μg/kg) güvercinlerde tek başına kullanılmamalı, kullanım mecburiyetinde kardiyopulmoner parametreler perianestezik olarak dikkatle takip edilmelidir. Deksmedetomi-din (40 μg/kg) ve ketamin (50 mg/kg) orta seviyede anestezi gerektiren klinik uygulamalarda kullanılabilir. Atipamezol güvercinlerde deksmedetomidinin dört katı dozda güvenle kullanılabilir.

Keywords

• Atipamezol
• deksmedetomidin
• güvercin
• ketamin

Evaluation of the Anesthetic Properties of Dexmedetomidine and Dexmedetomidine-Ketamine Combination and the Properties of Atipamezole as a Reversal Agent in Domestic Pigeons

Abstract

The aim of this study was to determine the anesthetic efficacy of dexmedetomidine and ketamine alone and dexmedetomidine-ketamine combination and the effects of α2 adrenergic reversal atipamezole in domestic pigeons (Columba livia). In DX group, dexmedetomidine (80 μg/kg), in K group, ketamine (100 mg/kg) alone, in DXK group, dexmedetomidine (40 μg/kg) and ketamine (50 mg/kg) consecutively were administered intramuscularly (IM). Anesthetic depth and cardiopulmonary symptoms were monitored starting from the pre-injection moment (T0) till the 60th minute (T60). At T60, atipamezole at a dosage 4 times that of dexmedetomidine was injected intramuscularly to the DX group (320 μg/kg) and the DXK group (160 μg/kg). In the DX group, only minimal sedation, bradycardia, and a sudden drop in respiratory rate were seen (P<0.05). The cardiopulmonary parameter values in the DXK group were affected to a less-er extent compared to the DK group. In the DXK group, 22.47±0.64 minutes after atipamezole injection, all pigeons were on their feet. As a result, it was concluded that dexmedetomidine (80 μg/kg) alone should not be used in pigeons, and if it is needed to be used, cardiopulmonary parameters should be carefully monitored peri-anesthetically. Dexmedetomidine (40 μg/kg) and ketamine (50 mg/kg) can be used in clinical practices that require a moderate level of anesthesia. Atipamezole can safely be used at 4 times the dosage of dexmedetomidine in pigeons.

Keywords

• Atipamezole
• dexmedetomidine
• ketamine
• pigeon

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