Kedi ve Köpek Dermatolojisinde Kriyoterapi Uygulamaları

Abstract

Kriyoterapi hızlı dondurma ve yavaş çözdürme prensibiyle çalışan, çevre dokulara minimum hasar verirken hedef doku parçasının dondurularak yok edilmesini sağlayan minimal invazif terapötik bir prosedürdür. Tüm vücut kriyoterapisi, buz uygulamaları, kriyojen madde türleri içeren kriyocerrahi uygulamaları gibi birçok çeşitten oluşur. Genellikle dermatolojide, lezyon tedavilerinde kullanılır ancak kullanım alanları sadece bununla sınırlı değildir ve beyin gibi ulaşılması zor dokularda da kullanımı raporlanmıştır. Temel prensibi olan ısı difüzyonu, bir kriyonekroz alan yaratır ve lezyondaki hücrelerin yıkımını sağlar. Bunun için üretilmiş olan veteriner kriyocerrahi ünitelerinde, genellikle, sıvı nitrojen ve nitröz oksit kullanılır. Doku boyutuna ve sitolojisine göre birkaç seans sonrasında, doku alanında tamamen iyileşmeler görülür. Günümüzde, ayakta tedavi olanakları, minimal anestezi süreleri ve düşük komplikasyon riskleri sayesinde özellikle yaşlı veya kalp yönünden riskli hayvanların kitle tedavilerinde umut ışığı olmaktadır. Bu derlemede, kriyoterapinin kedi ve köpek dermatolojisindeki kullanımının incelenmesi amaçlanmıştır.

Keywords

• Kriyoterapi
• Dermatoloji
• Neoplazi

Cryotherapy Applications in Cat and Dog Dermatology

Abstract

Cryotherapy is a minimally invasive therapeutic procedure that works on the principle of rapid freezing and slow thawing, allowing the target tissue to be destroyed by freezing while causing minimal damage to surrounding tissues. It consists of many types such as whole body cryotherapy, ice applications, and cryosurgery applications containing cryogenic substance types. It is generally used in dermatology and lesion treatments, but its areas of use are not limited to this and its use has also been reported in hard-to-reach tissues such as the brain. Its basic principle, heat diffusion, creates a cryonecrosis field and ensures the destruction of cells in the lesion. In veterinary cryosurgery units produced for this purpose, liquid nitrogen and nitrous oxide are generally used. Depending on the tissue size and cytology, complete recovery is observed in the tissue area after a few sessions. Today, thanks to outpatient treatment opportunities, minimal anesthesia times and low complication risks, it is a ray of hope in the mass treatment of especially elderly or heart-risk animals. This review aims to examine the use of cryotherapy in cat and dog dermatology.

Keywords

• Cryotherapy
• Dermatology
• Neoplasia

References

1. Aksakal AB, Akar A, Erbil H, Kurumlu Z. Kriyoterapi alopesi areata tedavisinde ilk seçeneklerden birisi olabilir mi? Turkiye Klinikleri J Dermatol 2000; 10(3): 184-7.
2. Angileri M, Furlanello T, Lucia MD. Cryotherapy to treat benign skin tumours in conscious dogs. Vet Dermatol 2020; 31(2): 163-6.
3. Azoulay T. Adjunctive cryotherapy for pigmentary keratitis in dogs: A study of 16 corneas. Vet Ophthalmol 2013; 17(4): 241-9.
4. Barış SD, Türkyılmaz A. Endodontide post-operatif ağrı yönetimine güncel bir yaklaşım: Kriyoterapi. Eur J Dent 2023; 7(3): 163-71.
5. Bleakley C, Davison GW. Cryotherapy and inflammation: evidence beyond the cardinal signs. Phys Ther Rev 2010; 15(6): 430-5.
6. Campbell KL. Small Animal Dermatology Secrets. First Edition. Pennsylvania: Elsevier Science, 2004; p. 319. Chesterton LS, Foster NE, Ross L. Skin temperature response to cryotherapy. Arch Phys Med Rehabil 2002; 83(4): 543-9.
7. Coyner KS, ed. Clinical Atlas of Canine and Feline Dermatology. First Edition. New Jersey: Wiley-Blackwell, 2020; pp. 404-9.
8. Dokuzeylul B, Kayar A, Or ME. Prevalence of systemic disorders in cats with oral lesions. Vet Med-Czech 2016; 61(4): 219-23.

9. Ferris DG, Ho JJ. Cryosurgical equipment: A critical review. J Fam Pract 1992; 35(2): 185-93.
10. Fesseha H, Yilma T. Cyrosurgery: Its principles and application-A review. CPQ Med 2020; 10(2): 1-18.
11. Gage AA, Baust JM, Baust JG. Experimental cryosurgery investigations in vivo. Cryobiology 2009; 59(3): 229-43.
12. Gökşin Ş, Aksoy S, Duygulu Ş. Atipik yerleşimli kutanöz larva migrans olgusu. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 2020; 7(1): 57-9.
13. Gürbüz C, Yurdakul İ. Prostat kanseri tedavisinde fokal tedaviler. Endourol Bull 2020; 12(1):53-61.
14. Han HS. Sporothrichosis. Noli C, Colombo S. eds. In: Feline Dermatology. First Edition. Gewerbestrasse: Springer Cham 2020; pp. 329-43.
15. Jackson HA, Marsella R. BSAVA Manual of Canine and Feline Dermatology. Third Edition. Gloucester: British Small Animal Veterinary Association 2012; p. 241.
16. Karakuzu A, Tatlı EU. Kriyoterapi. Turkderm-Turk Arch Dermatol Venerol 2018; 52(2): 76-7.
17. Kılıç S, Eröksüz Y, Ünsaldı S, Canpolat İ, Kulualp K. Bir ineğin göz kapağında bazal hücre karsinomu. YYU Veteriner Fakültesi Dergisi 2011; 22(1): 49-51.
18. Knottenbelt DC, McGarry JW, Pascoe RR. Pascoe’s Principles & Practice of Equine Dermatology. Second Edition. Edinburgh: Elsevier/Saunders 2009; pp. 123-25.
19. Lloyd DH, Littlewood JD, Craig JM, Thomsett LR. Practical Equine Dermatology. First Edition. Oxford: Blackwell Science 2003; p. 70.
20. Ma J, Yu X, Lv J, Lin D, Lin J, Bai Y, Wang Y, Li X, Dong J. Cryotherapy mediates histopathological and microstructural changes during the treatment of skin and subcutaneous tumors in dogs. Cryobiology 2021; 98: 164-71.
21. Malik R, Smits B, Reppas G, Laprie C, O’Brien C, Fyfe J. Ulcerated and nonulcerated nontuberculous cutaneous mycobacterial granulomas in cats and dogs. Vet Dermatol 2013; 24(1): 146-e33.
22. Mendoza Y, Colmenares A, Hernández‐Pereira CE, Shaban MV, Mogollón A, Morales‐Panza RJ, Suarez‐Alvarado MJ, Sordillo EM, Kato H, Paniz‐Mondolfi AE. Cutaneous leishmaniosis due to Leishmania mexicana in a cat treated with cryotherapy. Vet Dermatol 2022; 33(5): 450-3.
23. Miller WH, Griffin CE, Campbell KL. Muller & Kirk’s Small Animal Dermatology. Seventh Edition. Missouri: Elsevier Mosby 2013; pp. 156-8.
24. Nayeema S, Subha DRM. Cryotherapy–a novel treatment modality in oral lesions. Int J Pharm Sci 2013; 5(4): 4-5.
25. Olson JE, Stravino VD. A review of cryotherapy. Phys Ther 1972; 52(8): 840-53.
26. Pasricha PJ, Hill S, Wadwa KS, Gislason GT, Okolo III PI, Magee CA, Canto MI, Kuo WH, Baust JG, Kalloo AN. Endoscopic cryotherapy: experimental results and first clinical use. Gastrointest Endosc 1999; 49(5): 627-31.
27. Patel A, Forsythe P. Saunders Solutions in Veterinary Practice: Small Animal Dermatology. First Edition. UK: Saunders Elsevier 2008; p. 268.
28. Prado LOC, Rossetto VJV, Carvalho LMCR, Ferreira AP, Matsubara LM, Rodrigues JCZ, Brandão CVS. Evaluation of the cryosurgery for treatment of squamous cell carcinoma in cats. Arq Bras Med Vet Zootec 2017; 69(4): 877-82.
29. Quigley MR, Loesch DV, Shih T, Marquardt M, Lupetin A, Maroon JC. Intracranial cryosurgery in a canine model: A pilot study. Surg Neurol 1992; 38(2): 101-5.
30. Rhodes KH, Werner AH. Blackwell’s Five-Minute Veterinary Consult Clinical Companion Small Animal Dermatology. Third Edition. West Sussex: John Wiley & Sons 2018; pp. 161-3.
31. Richman AW, Kirby AL, Rosenkrantz W, Muse R. Persistent papilloma treated with cryotherapy in three dogs. Vet Dermatol 2017; 28(6): 625-e154.
32. Rodgers BM, McDonald AP, Talbert JL, Donnelly WH. Morphologic and functional effects of esophageal cryotherapy. J Thorac Cardiovasc Surg 1979; 77(4): 543-9.
33. Rodgers BM, Pappelis P. Profound endoesophageal cryotherapy. Cryobiology 1985; 22(1): 86-92.
34. Scott DW, Miller WH. Equine Dermatology. Second Edition. Missouri: Elsevier/Saunders 2011; p. 119.
35. Sharp B. Feline physiotherapy and rehabilitation: 1. Principles and potential. J Feline Med Surg 2012; 14(9): 622-32.
36. Tarım G, Cantürk T, Şentürk N, Turanlı AY. Dermatolojik tedavide kriyoterapi kullanımı. OMÜ Tıp Dergisi 2000; 17(3): 210-2.
37. Verebová V, Staničová J. The effect of the cryotherapy on the health and welfare of dogs: preliminary study. Folia Veterinaria 2022; 66(4): 31-9.
38. Woo SC, Lee J, Millis DL, Drum MG. Thermographic evaluation of the duration of skin cooling after cryotherapy in dogs following tibial plateau leveling osteotomy surgery. Front Vet Sci 2022; 9: 1-7.
39. Yosipovitch G, Sugeng MW, Goon A, Chan YH, Goh CL. A comparison of the combined effect of cryotherapy and corticosteroid injections versus corticosteroids and cryotherapy alone on keloids: a controlled study. J Dermatolog Treat 2001; 12(2): 87-90.