Köpek ve Kedilerde Cerrahi Yara Enfeksiyonu ve Profilaktik Antibiyotik Kullanımı

Abstract

Bu derlemede, cerrahi yara enfeksiyonu ve cerrahide profilaktik antibiyotik kullanımı değerlendirilmektedir. Hayvanlarda

cerrahi yara enfeksiyonları ciddi ekonomik kayıplara yol açan bir komplikasyondur. Operasyon yaraları organ ve dokuların,

dışarıdaki kontaminantlarla direkt olarak temasına neden olarak, enfeksiyona neden olan bakterilerin içeri girmesini

sağlamış olurlar. Etkili bir antibiyotik profilaksisi için, antibiyotiklerin operasyon boyunca bölgeyi kontamine eden patojen

mikroorganizmaları öldürmek ve üremesini engellemek için operasyon bölgesinde yeterli konsantrasyonlarda bulunması

gerekir. Profilaktik olarak antibiyotik uygulanması cerrahi yara enfeksiyonu insidensini azaltmasına rağmen, uygun olmayan

antibiyotiğin kullanılması gereksiz masraflar, antibiyotik direncinin artması ve süperenfeskiyonlarla sonuçlanır. Sonuç olarak,

cerrahi yara enfeksiyonlarından korunmada, cerrahi asepsiye ve profilaktik olarak uygun antibiyotiğin kullanılmasına sadık

kalmanın oldukça önemli olduğu kanısına varılmıştır.

Keywords

• Antimikrobiyal proflaksi,cerrahi yara,enfeksiyon,kedi,köpek

Surgical Wound Infection and Prophylactic Antibiotic Use in Dogs and Cats

Abstract

In this review, surgical wound infection and the use of prophylactic antibiotics in surgery have been evaluated.

Surgical wound infections are the complications that cause serious economic losses in animals. Operation wounds facilitate

the entering of infectious bacteria into the body through direct contamination of organ and tissue with the contaminants

outside. For an effective antibiotic prophylaxis, antibiotics must be present in sufficient concentrations in operation side

to prevent the proliferation of microorganisms and kill those that contaminate the area during the operation. Although

prophylactic administration of antibiotics reduces the incidence of surgical wound infections, improper use of antibiotics leads

to unnecessary expenses, resulting in increased antibiotic resistance or superinfections. As a result, it is concluded that

surgical asepsis and the use of appropriate antibiotics prophylaxis are very important for the prevention of surgical wound

infections

Keywords

• Antimicrobial prophylaxis,cat,dog,infection,surgical wound

References

1. 1. Andrej Trampuz A, Widmer AF. Ortopedik implantlarla ilişkili enfeksiyonlar. Curr Opin Infect Dis 2006; 1(3): 158-67.
2. 2. Bratzler DW, Houck PM. Antimicrobial prophylaxis for surgery: an advisory statement from the National Surgical Infection Prevention Project. Clin Infect Dis 2004; 38(15): 1706-15.
3. 3. Beal MW, Brown DC, Shofer FS. The effects of perioperative hypothermia and the duration of anesthesia on postoperative wound infection rate in clean wounds: a retrospective study. Vet Surg 2000; 29(2): 123-7.
4. 4. Billings L, Vasseur PB, Fancher C, Miller M, Nearenberg D. Wound infection rates in dogs and cats after use of cotton muslin or disposable impermeable fabric as barrier material: 720 cases (1983-1989). J Am Vet Med Assoc 1990; 197(7): 889-92.
5. 5. Biricik HS. Cerrahi yara enfeksiyonun nedenleri ve önlenmesi. Vet Cer Derg 2003; 9(1-2): 63-7.
6. 6. Brown DC, Conzemius MG, Shofer F, Swann H. Epidemiologic evaluation of postoperative wound infections in dogs and cats. J Am Vet Med Assoc 1997; 210(9): 1302-06.
7. 7. Cockshutt J. Principles of Surgical Asepsis In: Textbook of Small Animal Surgery, Third Edition. Philadelphia: WB Saunders Company, 2003; pp. 149-55.
8. 8. Duade-Lagrave A, Carozzo C, Fayolle P, Yiguier E, Yiateau V, Moissonnier P. Infection rates in surgical procuders: a comparison of cefalexin vs. a placebo. Vet Comp Orthop Traumatol 2001; 14(3): 146-50.

9. 9. Dunnig D. Surgical Wound Infection and The Use of Antimicrobials. In: Textbook of Small Animal Surgery. Third Edition. Philadelphia: WB Saunders Company, 2003; pp. 113-22.
10. 10. Eugster S, Schawalder P, Gaschen F, Boerlin P. A prospective study of postoperative surgical site infections in dogs and cats. Vet Surg 2004; 33(5): 542-50.
11. 11. Gibson KL, Donald AW, Hariharan H, McCarville C. Comparison of two pre-surgical skin preparation techniques. Can J Vet Res 1997; 61(2): 154-6.
12. 12. Gyssens IC. Preventing postoperative infections: Current treatment recommendations. Drugs 1999; 57(2): 175-85.
13. 13. Heldmann E, Brown DC, Shofer F. The association of propofol usage with postoperative wound infection rate in clean wounds: a retrospective study. Vet Surg 1999; 28(4): 256-9.
14. 14. Hosgood G. Wound complications following thoracolumbar laminectomy in the dog: A retrospective study of 264 procedures. J Am Anim Hosp Assoc 1992; 28(1): 47-52.
15. 15. Howe LM, Boothe HW. Antimicrobial use in surgical patient. Vet Clin North Small Animal Pract 2006; 36(5): 1049-60.
16. 16. Lambrechts NE, Hurter K, Picard JA, Goldin JP, Thompson PN. A prospective comparison between stabilized glutaraldehyde and chlorhexidine gluconate for preoperative skin antisepsis in dogs. Vet Surg 2004; 33(6): 636-43.
17. 17. McDonald M, Grabsch E, Marshall C, Forbes A. Single-versus multiple–dose antimicrobıal prophylaxis for major surgery: A systematic review. Aust N Z J Surg 1998; 68(6): 388-96.
18. 18. Manian FA, Meyer PL, Setzer J, Senkel D. Surgical site infections associated with methicillin-resistant Staphylococcus aureus: do postoperative factors play a role? Clin Infect Dis 2003; 36 (7): 863-8.
19. 19. Mutinati M, Spedicato M, Manca, Trisolini C, Minoina G, Rizzo A, Sciors RL. Influence of antibiotic therapy on serum levels of reactive oxygen species in ovariectomized bitches. J Vet Pharmacol Therap 2007; 31(1): 18-21.
20. 20. Morita S, Nishisho I, Nomura T, Fukushima Y, Morimoto T, Hiraoka N, Shibata N. The Significance of the intraoperative repeated dosing of antimicrobials for preventing surgical wound infection in colorectal surgery. Surg Today 2005; 35(9): 732-8.
21. 21. Nicholson M, Beal M, Shofer F, Brown DC. Epidemiologic evaluation of postoperative wound infection in clean-contaminated wounds: A retrospective study of 239 dogs and cats. Vet Surg 2002; 31(6): 577-81.
22. 22. Nichols RL. Preventing surgical site infections. Clin Med Res 2004; 2(2): 115-8.
23. 23. Queiroz R, Grinbaum RS, Galvao LL, Tavares FG, Bergsten-Mendes G. Antibiotic prophylaxis in orthopedic surgeries: the results of an implemented protocol. Braz J Infect Dis 2005; 9(4): 283-87.
24. 24. Romatowski J. Prevention and control of surgical wound infection. J Am Vet Med Assoc 1989; 194(1): 107-14.
25. 25. Rosin E, Ebert S, Uphoff TS, Evans MH, Schultz-Darken NJ. Penetration of antibiotics into the surgical wound in a canine model. Antimicrob Agents Chemother 1989; 33(5): 700-4.
26. 26. Rosin E, Uphoff TS, Schultz-Darken NJ, Collins MT. Cefazolin antibacterial activity and concentrations in serum and the surgical wound in dogs. Am J Vet Res 1993; 54(8): 1317-21.
27. 27. Simmy T, Anup R, Prabhu KA, Balasubramanian KA. Effect of surgical manipulation of the rat intestine on enterocyte populations. Surgery 2001; 130(3): 479–88.
28. 28. Uzunköy A. Cerrahide antibiyotik proflaksisi. ANKEM Derg. 2005; 19(1): 55-9.
29. 29. Ünsaldı C, Günay C. Köpeklerde pre-operatif tek doz antibiyotik profilaksisi. Fırat Uni Sağlık Bil Derg 2001; 15(1): 85-90.
30. 30. Vogel PL, Komtebedde J, Hirsh DC, Kass PH. Wound contamination and antimicrobial susceptibility of bacteria cultured during total ear canal ablation and lateral bulla osteotomy in dogs. J Am Vet Med Assoc 1999; 214(11): 1641-3.
31. 31. Weed HG. Antimicrobial prophylaxis in the surgical patient. Med Clin North Am. 2003; 87: 59-75.
32. 32. Weese JS, Halling KB. Perioperative administration of antimicrobials associated with elective surgery for cranial cruciate ligament rupture in dogs: 83 cases (2003-2005). J Am Vet Med Assoc 2006; 229(1): 92-5.
33. 33. Whittem TL, Johnson AL, Smith CW, Schaeffer DJ, Coolman BR, Averill SM, Cooper TK, Merkin GR. Effect of perioperative prophylactic antimicrobial treatment in dogs undergoing elective orthopedic surgery. J Am Vet Med Assoc 1999; 215(2): 212-6.
34. 34. Wilcke JR. Use of antimicrobial drugs to prevent infections in veterinary peatients. Probl Vet Med 1990; 2(2): 298-311.
35. 35. Wilson MA. Skin and soft-tissue infections: Impact of resistant gram-positive bacteria. Am J Surg 2003; 186(28): 36–41.
36. 36. Yu-Speight AW, Kern TJ, Erb HN. Ciprofloxacin and ofloxacin aqueous humor concentrations after topical administration in dogs undergoing cataract surgery. Vet Ophthalmol 2005; 8(3): 181–87.