Nonsteroidal Antiinflamatuvar İlaçların Kedi ve Köpeklerde Etkili ve Güvenli Kullanımı

Year 2014, Volume: 11 Issue: 2, 137 - 143, 01.08.2014

Ümit Karademir Murat Boyacıoğlu

Abstract

Nonsteroidal antiinflamatuvar ilaçların (NSAİİ) ağrı kesici, ateş düşürücü, yangı önleyici etkilerinin yanında antiromatizmal

etkilerinin de olması nedeniyle veteriner hekimlikte kullanımı oldukça yaygındır. NSAİİ’ların kimyasal yapıları

birbirinden farklı olmasına rağmen, prostoglandinlerin üretimine aracılık eden siklooksijenaz enzimini (COX) inhibe ederek

etkinlik gösterirler. COX enzimi COX-1, COX-2 ve COX-3 olmak üzere üçe ayrılmaktadır. NSAİİ’lar COX-1 ve COX-2’yi

farklı derecelerde inhibe ederek yangıya yol açan prostaglandinlerin üretimini azaltırlar. NSAİİ’ların kullanılmasına bağlı

olarak şiddetli organ disfonksiyonları ile sonuçlanabilen bozukluklar oluşabilir. NSAİİ’ların istenmeyen yan etkilerinden

kedi ve köpeklerin diğer hayvan türlerinden daha fazla etkilendiği belirtilmektedir. Bu kapsamda klinik açıdan önemli

bazı yangı önleyici ilaçların kedi ve köpeklerde etkili ve güvenli kullanımı değerlendirilecektir.

Keywords

Kedi, köpek, nonsteroidal antiinflamatuvar ilaç, siklooksijenaz

The Effective and Safe use of Nonsteroidal Antiinflammatory Drugs in Dogs and Cats

Abstract

Non-Steroidal Anti-Inflammatory Drugs (NSAID) are commonly used in veterinary medicine because of

their analgesic, antipyretic, anti-inflammatory effects in addition to their anti-rheumatic effects. Despite differences in

chemical structures of the NSAID, these compounds share the effect of inhibiting the production of prostoglandins by

targeting the cyclooxygenase (COX) pathway. Three primary forms of COX have been identified as COX-1, COX-2 and

COX-3. The NSAIDs reduce the production of prostoglandins causing inflamation by inhibitting the COX-1 and COX-

2 enzymes in different levels. Depending on the use of NSAIDs, severe organ dysfunctions may occur. The clinical

adverse effects associated with NSAID administration are observed more often in dogs and cats than other animals. In

this review, some clinically important anti-inflammatory drugs will be evaluated in terms of their effective and safe use

in cats and dogs.

Keywords

Cat, dog, nonsteroidal antiinflammatory drug, cyclooxygenase

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